Click here to switch to the map view.

The map label for this gene is proG [H]

Identifier: 52785159

GI number: 52785159

Start: 1389569

End: 1390381

Strand: Direct

Name: proG [H]

Synonym: BLi01391

Alternate gene names: 52785159

Gene position: 1389569-1390381 (Clockwise)

Preceding gene: 52785157

Following gene: 52785160

Centisome position: 32.91

GC content: 50.06

Gene sequence:

>813_bases
TTGAACAAGATTGGATTTATCGGATACGGAAGCATGGCACAGATGATTGCGGTGAAACTGCTAGATCAGGGGAAAATCAG
GGATGACATGGTGGTCGTCAGCTCAAGGAATGACGGGAAAACAGAGGAGCTGAAAAAGCTTTATCCGAATGTCGCCTGTC
AATCAGCTGATGAGCTCGCCAAACAGTGCGGCCTGATCTTCATCTGTGTACCGCCGATGGCGGTAAAAGAAACGCTTGAA
AAAATACAGCCGTTTCTTCAGGAGGATGTCCACATCGTTTCGATTGCCGCGGGGGTCGAGCTTGACCGGCTTCACGACTG
GACAAGCGGACAGGTGACGAGATACATTCCGACACTCACATCTGAAGCCGGGATCGGCGTTTCGCTTGTTGTCCACGGCG
AGCGGGTCGCTGAGGCGGACAAAAGCCGGCTGGAAGAATATCTTTCCGCCTTCAGCACAGTCAAACAGATCAATGAGAGA
GATATTGACGCTGCGAGCAATTTAACAAGCTCTTCACCGGGGTTCATCGCTTCGATTTTTGAAGAATTTGCTCAAGCCGC
CGTCAGAAACAGCAGCCTCACGAAAGAAGAAGCGTTTCAATTTCTGATTCATTCATTGCTGGGAACAGGCAAGCTGTTAA
TGGAAAAAGACATGACGTTTGCTCAAACGCTTGATCGGGTGGCGACAAAAGGCGGCATAACCGCAGAAGGTGCGGAAGTC
ATTCAAGATGCCATGCCGGAAGTCTTTGACGAGCTGTTTGCCAGAACGATGAAGAAATATGAAGTCATCAAAGACGCTGT
CCGCCGGCAGTGA

Upstream 100 bases:

>100_bases
GTGGGATAAACATGAAAACATTGTGGGAAATTGTCAAAGAAAAAGGATAGAATATATAGGGTGCTATTTATAATATGACA
TGTCAGAGGTGTTCTAAACG

Downstream 100 bases:

>100_bases
ACCGCGGCATTCATCGACATATCCGGATATCCGCAAGCTGCCTGACCAGGCAGCTTTTTTATTTGCATTCGACAACATTC
ATCAAAATTCCAATTTTATA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase 3; P5CR 3 [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNKIGFIGYGSMAQMIAVKLLDQGKIRDDMVVVSSRNDGKTEELKKLYPNVACQSADELAKQCGLIFICVPPMAVKETLE
KIQPFLQEDVHIVSIAAGVELDRLHDWTSGQVTRYIPTLTSEAGIGVSLVVHGERVAEADKSRLEEYLSAFSTVKQINER
DIDAASNLTSSSPGFIASIFEEFAQAAVRNSSLTKEEAFQFLIHSLLGTGKLLMEKDMTFAQTLDRVATKGGITAEGAEV
IQDAMPEVFDELFARTMKKYEVIKDAVRRQ

Sequences:

>Translated_270_residues
MNKIGFIGYGSMAQMIAVKLLDQGKIRDDMVVVSSRNDGKTEELKKLYPNVACQSADELAKQCGLIFICVPPMAVKETLE
KIQPFLQEDVHIVSIAAGVELDRLHDWTSGQVTRYIPTLTSEAGIGVSLVVHGERVAEADKSRLEEYLSAFSTVKQINER
DIDAASNLTSSSPGFIASIFEEFAQAAVRNSSLTKEEAFQFLIHSLLGTGKLLMEKDMTFAQTLDRVATKGGITAEGAEV
IQDAMPEVFDELFARTMKKYEVIKDAVRRQ
>Mature_270_residues
MNKIGFIGYGSMAQMIAVKLLDQGKIRDDMVVVSSRNDGKTEELKKLYPNVACQSADELAKQCGLIFICVPPMAVKETLE
KIQPFLQEDVHIVSIAAGVELDRLHDWTSGQVTRYIPTLTSEAGIGVSLVVHGERVAEADKSRLEEYLSAFSTVKQINER
DIDAASNLTSSSPGFIASIFEEFAQAAVRNSSLTKEEAFQFLIHSLLGTGKLLMEKDMTFAQTLDRVATKGGITAEGAEV
IQDAMPEVFDELFARTMKKYEVIKDAVRRQ

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=246, Percent_Identity=27.2357723577236, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI21361454, Length=241, Percent_Identity=25.7261410788382, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786585, Length=246, Percent_Identity=28.0487804878049, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17569021, Length=239, Percent_Identity=28.8702928870293, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540664, Length=256, Percent_Identity=26.953125, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21358587, Length=239, Percent_Identity=26.3598326359833, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24648116, Length=246, Percent_Identity=26.8292682926829, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29770; Mature: 29770

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIGFIGYGSMAQMIAVKLLDQGKIRDDMVVVSSRNDGKTEELKKLYPNVACQSADELA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCHHHCCHHHHH
KQCGLIFICVPPMAVKETLEKIQPFLQEDVHIVSIAAGVELDRLHDWTSGQVTRYIPTLT
HHCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHCCCCCCCHHHHHHHHC
SEAGIGVSLVVHGERVAEADKSRLEEYLSAFSTVKQINERDIDAASNLTSSSPGFIASIF
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHH
EEFAQAAVRNSSLTKEEAFQFLIHSLLGTGKLLMEKDMTFAQTLDRVATKGGITAEGAEV
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCHHHHH
IQDAMPEVFDELFARTMKKYEVIKDAVRRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKIGFIGYGSMAQMIAVKLLDQGKIRDDMVVVSSRNDGKTEELKKLYPNVACQSADELA
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCHHHCCHHHHH
KQCGLIFICVPPMAVKETLEKIQPFLQEDVHIVSIAAGVELDRLHDWTSGQVTRYIPTLT
HHCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHCCCCCCCHHHHHHHHC
SEAGIGVSLVVHGERVAEADKSRLEEYLSAFSTVKQINERDIDAASNLTSSSPGFIASIF
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHH
EEFAQAAVRNSSLTKEEAFQFLIHSLLGTGKLLMEKDMTFAQTLDRVATKGGITAEGAEV
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCHHHHH
IQDAMPEVFDELFARTMKKYEVIKDAVRRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 1766370; 11418582 [H]