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The map label for this gene is yjbV [H]

Identifier: 52785036

GI number: 52785036

Start: 1275778

End: 1276596

Strand: Direct

Name: yjbV [H]

Synonym: BLi01265

Alternate gene names: 52785036

Gene position: 1275778-1276596 (Clockwise)

Preceding gene: 52785035

Following gene: 52785037

Centisome position: 30.21

GC content: 49.82

Gene sequence:

>819_bases
ATGAGCATATATAAAGCATTAACAATCGCCGGATCGGATTCAGGAGGCGGAGCCGGCATTCAAGCCGACATTAAAACATT
TCAGGAGCTTGGCGTCTTCGGCATGACAGTTTTGACAGCAGTCACTGCGCAAAATACAACAGGGGTTCACGGCGTCTACC
CGCTTTCTCCGGAAGCGCTCGGCGCACAGATTGATGCAGTGGCAGAAGATTTAAAACCTGACGCCGTGAAAACAGGGATG
CTGTGGAGCGCGGAGATGATTGAGGTCACTGCTGAAAAAATTGCAGCATATGAGCTTAAACGTGTGATCGTCGATCCTGT
CATGATCGCCAAAGGCGGCGCTTCACTATTGAATGAGGAAGCTGTTGAAACATTGAAACGGCGCCTTCTTCCGCTTGCTT
ATGCGGTAACGCCAAACATTCCCGAAGCCGAAGTGCTGACAGGGAGAAGCATTCAAACAATGGAAGACCGCAAAAAAGCA
GCTCGTGACTTGCATGAAATGGGCGTCCGCAACATTATCATCAAGGGAGGTCATCAGCCTGAGGATGGCAAAGTAACCGA
TCTCCTCTTCGACGGAGAGACGTTCACAGAAAAAACCAATTCCTATATTAAGACGAAAAATACCCATGGAACAGGCTGTA
CATTTGCCGCGGCTCTTACGGCGCAATCAGCGAAAGGAAACGGGATTCAAGGAGCTTTCCGCATCGCTGAGGCTTTCGTC
CACGAAGCGGTTGTACACAGCCTTGATTTTGGAGCCGGCCACGGACCGACCAACCATTTTGCATATCAAAAGTTATCCAA
CGCAGGGTTGGAACTGTAG

Upstream 100 bases:

>100_bases
GGATGGACGTGCTTTAATTCACGGAACGAATGACATCAATCGCGCGAAAACGATATATCACAGGTGGATTGGCTAAAAGG
CCGAAGGGAGTGCAAACATC

Downstream 100 bases:

>100_bases
TCCCGCAATAAGAAAGAATCAATATCGCGGCAGAGCATCAAAAACGGCCTCTGCCGCTTTTTATATTCTGAAATTGTCAG
CCTGCTATTAATTGTGATAC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSIYKALTIAGSDSGGGAGIQADIKTFQELGVFGMTVLTAVTAQNTTGVHGVYPLSPEALGAQIDAVAEDLKPDAVKTGM
LWSAEMIEVTAEKIAAYELKRVIVDPVMIAKGGASLLNEEAVETLKRRLLPLAYAVTPNIPEAEVLTGRSIQTMEDRKKA
ARDLHEMGVRNIIIKGGHQPEDGKVTDLLFDGETFTEKTNSYIKTKNTHGTGCTFAAALTAQSAKGNGIQGAFRIAEAFV
HEAVVHSLDFGAGHGPTNHFAYQKLSNAGLEL

Sequences:

>Translated_272_residues
MSIYKALTIAGSDSGGGAGIQADIKTFQELGVFGMTVLTAVTAQNTTGVHGVYPLSPEALGAQIDAVAEDLKPDAVKTGM
LWSAEMIEVTAEKIAAYELKRVIVDPVMIAKGGASLLNEEAVETLKRRLLPLAYAVTPNIPEAEVLTGRSIQTMEDRKKA
ARDLHEMGVRNIIIKGGHQPEDGKVTDLLFDGETFTEKTNSYIKTKNTHGTGCTFAAALTAQSAKGNGIQGAFRIAEAFV
HEAVVHSLDFGAGHGPTNHFAYQKLSNAGLEL
>Mature_271_residues
SIYKALTIAGSDSGGGAGIQADIKTFQELGVFGMTVLTAVTAQNTTGVHGVYPLSPEALGAQIDAVAEDLKPDAVKTGML
WSAEMIEVTAEKIAAYELKRVIVDPVMIAKGGASLLNEEAVETLKRRLLPLAYAVTPNIPEAEVLTGRSIQTMEDRKKAA
RDLHEMGVRNIIIKGGHQPEDGKVTDLLFDGETFTEKTNSYIKTKNTHGTGCTFAAALTAQSAKGNGIQGAFRIAEAFVH
EAVVHSLDFGAGHGPTNHFAYQKLSNAGLEL

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=42.2053231939163, Blast_Score=204, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6325378, Length=267, Percent_Identity=33.7078651685393, Blast_Score=146, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324997, Length=268, Percent_Identity=36.1940298507463, Blast_Score=131, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6324517, Length=268, Percent_Identity=34.7014925373134, Blast_Score=126, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28851; Mature: 28720

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYKALTIAGSDSGGGAGIQADIKTFQELGVFGMTVLTAVTAQNTTGVHGVYPLSPEAL
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHH
GAQIDAVAEDLKPDAVKTGMLWSAEMIEVTAEKIAAYELKRVIVDPVMIAKGGASLLNEE
HHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHH
AVETLKRRLLPLAYAVTPNIPEAEVLTGRSIQTMEDRKKAARDLHEMGVRNIIIKGGHQP
HHHHHHHHHHHHHEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCC
EDGKVTDLLFDGETFTEKTNSYIKTKNTHGTGCTFAAALTAQSAKGNGIQGAFRIAEAFV
CCCCEEEEEECCCHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
HEAVVHSLDFGAGHGPTNHFAYQKLSNAGLEL
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIYKALTIAGSDSGGGAGIQADIKTFQELGVFGMTVLTAVTAQNTTGVHGVYPLSPEAL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHH
GAQIDAVAEDLKPDAVKTGMLWSAEMIEVTAEKIAAYELKRVIVDPVMIAKGGASLLNEE
HHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHH
AVETLKRRLLPLAYAVTPNIPEAEVLTGRSIQTMEDRKKAARDLHEMGVRNIIIKGGHQP
HHHHHHHHHHHHHEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHEEEEECCCCC
EDGKVTDLLFDGETFTEKTNSYIKTKNTHGTGCTFAAALTAQSAKGNGIQGAFRIAEAFV
CCCCEEEEEECCCHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
HEAVVHSLDFGAGHGPTNHFAYQKLSNAGLEL
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]