Click here to switch to the map view.

The map label for this gene is prsA [H]

Identifier: 52784844

GI number: 52784844

Start: 1075286

End: 1076146

Strand: Reverse

Name: prsA [H]

Synonym: BLi01072

Alternate gene names: 52784844

Gene position: 1076146-1075286 (Counterclockwise)

Preceding gene: 52784847

Following gene: 52784837

Centisome position: 25.49

GC content: 41.93

Gene sequence:

>861_bases
ATGAAGAAGATTGCAATTGCGGCGATTACAGCGACAAGCGTGCTGGCTCTCAGCGCATGCAGCGGGGGAGATTCTGAGGT
TGTTGCGGAAACAAAAGCTGGAAATATTACAAAAGAAGACCTTTATCAAACATTAAAAGACAATGCCGGAGCGGACGCAC
TGAACATGCTTGTTCAGCAAAAAGTACTCGATGATAAATACGATGTCTCCGACAAAGAAATCGACAAAAAGCTGAACGAG
TACAAAAAATCAATGGGTGACCAGCTCAACCAGCTCATTGACCAAAAAGGCGAAGACTTCGTCAAAGAACAGATCAAATA
CGAACTTCTGATGCAAAAAGCCGCAAAGGATAACATAAAAGTAACCGATGATGACGTAAAAGAATATTATGACGGCCTGA
AAGGCAAAATCCACTTAAGCCACATTCTTGTGAAAGAAAAGAAAACGGCTGAAGAAGTTGAGAAAAAGCTGAAAAAAGGC
GAAAAATTCGAAGACCTTGCAAAAGAGTATTCAACTGACGGTACAGCCGAAAAAGGCGGCGACCTCGGCTGGGTCGGCAA
AGACGATAACATGGACAAGGATTTCGTCAAAGCGGCATTTGCTTTGAAAACCGGCGAAATCAGCGGACCTGTGAAATCCC
AATTCGGCTATCACATCATTAAAAAAGACGAAGAACGCGGCAAATATGAAGACATGAAAAAAGAGCTTAAAAAAGAAGTC
CAAGAACAAAAGCAAAATGATCAAACTGAACTGCAATCCGTCATTGACAAACTTGTCAAAGATGCTGATTTAAAAGTAAA
AGACAAAGAGTTGAAAAAACAAGTCGACCAGCGTCAAGCTCAGACAAGCAGCAGCAGCTGA

Upstream 100 bases:

>100_bases
GATGCCCCTCTGTTGAAAATCTTTTTACAGCATGTCAGAATATGATATGATACAATTCAAAGGAAAGTTTAAACTGTTAT
GATTAGGAGTGTTTGCATTT

Downstream 100 bases:

>100_bases
CGCCAAAAAAGCTGTCCTCCCCTCGTTGGGGTCGGACAGCTTTTTTTATGCGATGGAATGGCTGTCAGCCGATTTTTCAT
GCTGTTCTTGATCTTCATCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MKKIAIAAITATSVLALSACSGGDSEVVAETKAGNITKEDLYQTLKDNAGADALNMLVQQKVLDDKYDVSDKEIDKKLNE
YKKSMGDQLNQLIDQKGEDFVKEQIKYELLMQKAAKDNIKVTDDDVKEYYDGLKGKIHLSHILVKEKKTAEEVEKKLKKG
EKFEDLAKEYSTDGTAEKGGDLGWVGKDDNMDKDFVKAAFALKTGEISGPVKSQFGYHIIKKDEERGKYEDMKKELKKEV
QEQKQNDQTELQSVIDKLVKDADLKVKDKELKKQVDQRQAQTSSSS

Sequences:

>Translated_286_residues
MKKIAIAAITATSVLALSACSGGDSEVVAETKAGNITKEDLYQTLKDNAGADALNMLVQQKVLDDKYDVSDKEIDKKLNE
YKKSMGDQLNQLIDQKGEDFVKEQIKYELLMQKAAKDNIKVTDDDVKEYYDGLKGKIHLSHILVKEKKTAEEVEKKLKKG
EKFEDLAKEYSTDGTAEKGGDLGWVGKDDNMDKDFVKAAFALKTGEISGPVKSQFGYHIIKKDEERGKYEDMKKELKKEV
QEQKQNDQTELQSVIDKLVKDADLKVKDKELKKQVDQRQAQTSSSS
>Mature_286_residues
MKKIAIAAITATSVLALSACSGGDSEVVAETKAGNITKEDLYQTLKDNAGADALNMLVQQKVLDDKYDVSDKEIDKKLNE
YKKSMGDQLNQLIDQKGEDFVKEQIKYELLMQKAAKDNIKVTDDDVKEYYDGLKGKIHLSHILVKEKKTAEEVEKKLKKG
EKFEDLAKEYSTDGTAEKGGDLGWVGKDDNMDKDFVKAAFALKTGEISGPVKSQFGYHIIKKDEERGKYEDMKKELKKEV
QEQKQNDQTELQSVIDKLVKDADLKVKDKELKKQVDQRQAQTSSSS

Specific function: Essential protein that plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. Has PPIase activity but it is not essential for its function in vivo [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1790211, Length=81, Percent_Identity=43.2098765432099, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1786238, Length=191, Percent_Identity=23.5602094240838, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF05698 Trigger_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32139; Mature: 32139

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1956302; 9579061; 9384377; 3145906 [H]