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The map label for this gene is nhaC [H]

Identifier: 52784813

GI number: 52784813

Start: 1040131

End: 1041489

Strand: Reverse

Name: nhaC [H]

Synonym: BLi01041

Alternate gene names: 52784813

Gene position: 1041489-1040131 (Counterclockwise)

Preceding gene: 52784815

Following gene: 52784811

Centisome position: 24.66

GC content: 50.48

Gene sequence:

>1359_bases
TTGTCAAACGAAAAACGACTATCGTTTTCCATATCGGCTCTATTGTTTATGGCCATATTGTTTATTATTTTCACCTGCTT
ATTCATATTTAAAGCAGAACCGCACATACCGCTTTTGATTTGCGTCGGTTTTTTGGCCGCTGTCGGCGCGGTGAAAGGGC
ATTCTTGGAAAGATCTTGAGAGCGGCATTGTCTCAGGCATCCGAAATGGCGTTCAGCCGATCATCATCCTTTGCCTAATC
GGCATCTTAATCGGAGTCTGGGAGTACAGCGGCGCGATTCCGACGGTAACGGTTTACGCGTTGAATCTGATTGAACCGCA
GCACCTGCTGCTCACCGCACTTTTCAGCTGTCTTGTGATCAGTTCATTGGTCGGCTCCAGCTTTACGACGGTCAGCACGA
TCGGCGTCGCCCTCATCGGTGTGGCCGCGGCGGCAGGCGTTCCACTGACATGGGCGGCGGGAGCCGTGATTTGCGGCGCC
TGCTTCGGCGACAAAATGTCTCCAATGTCAGACACGACCAACTTTGCCGCAGGAGTCGGGGAGCTTCCGATTTTCAAGCA
TATCAGACATATGGCGGGAACGACGATCCCCGCTCTTTTGATCACGATTTTGCTTTTCTTTTTCATGGGCCGTTCTTTAA
CGGCGGCACCGGCTTCAACCGAAAACATTCAAGCGATCATAAACGGAATAGAAGGCATGGTCAACATCAGCGTCTTCACG
CTTCTGTCGCCTCTGCTTGTGATTGTACTTGCTGTCAGACGGACGCCCGTCATTCCGTCGCTTGCAGCAGGGATCGTTTC
CGCCGGAATTTTTGCCGCGCTGATTCAGCCTGACGCCGGCATTTCATCGTTTTTGTCAGCGATGCAGAATGGCCCGGTTT
TCTCAGCCGATACTGAAGCCGTTGAAAAGATTTTAAATCGCGGCGGCCTTCAATCGATGATGGGCTCTGTTTCTCTCATC
ATCATCGCATTCGCGCTCGGCGGTCTCATGGAAAAGATCGGCATGATTACAAGCCTGCTTGAAGGCGTAATCAAGGGCAT
TCATACGAAAGGCCGGCTTGTGTTCTCAACCGTTTCATCAAGCATCGGCATGAACCTGGCGACAGGAGAACAGTATTTAT
CGATCTTGATTCCCGGTCAGTCCTTTAAAAAGCTGTATGACAAGCTTGGAATCGACCGGAAGCATTTGTCGAGATCACTT
GAAGACGGAGGGACATTAATTAATCCGATGATCCCATGGGGAGTCAGCGGCGCGTTCATGTCCACAGCGCTCGGCGTTCC
CGTCATTGAATATTTGCCGTTTGTGTTTTTCCTTTATTTATCGCCGCTCTTTTCGATTTTGTTCGGTTTCCGCAAATAA

Upstream 100 bases:

>100_bases
TTTAATTTAAGTATATGATCTATTTTTCTGTTATAATACGTTTACGCACAAAAGCATAAAAGTATTAAAGAAAGAGATTT
CTTCTAATGAGGTGTATGAT

Downstream 100 bases:

>100_bases
AAAAACGCCGTTTCCCCAGGAGACGGCGTTTTTCTTTGTTAAACCGTTTTGGCTGTTTCCGACAAAATGCTGTTTTGCAA
AGCGGTCTGCACATTTTTTG

Product: hypothetical protein

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSNEKRLSFSISALLFMAILFIIFTCLFIFKAEPHIPLLICVGFLAAVGAVKGHSWKDLESGIVSGIRNGVQPIIILCLI
GILIGVWEYSGAIPTVTVYALNLIEPQHLLLTALFSCLVISSLVGSSFTTVSTIGVALIGVAAAAGVPLTWAAGAVICGA
CFGDKMSPMSDTTNFAAGVGELPIFKHIRHMAGTTIPALLITILLFFFMGRSLTAAPASTENIQAIINGIEGMVNISVFT
LLSPLLVIVLAVRRTPVIPSLAAGIVSAGIFAALIQPDAGISSFLSAMQNGPVFSADTEAVEKILNRGGLQSMMGSVSLI
IIAFALGGLMEKIGMITSLLEGVIKGIHTKGRLVFSTVSSSIGMNLATGEQYLSILIPGQSFKKLYDKLGIDRKHLSRSL
EDGGTLINPMIPWGVSGAFMSTALGVPVIEYLPFVFFLYLSPLFSILFGFRK

Sequences:

>Translated_452_residues
MSNEKRLSFSISALLFMAILFIIFTCLFIFKAEPHIPLLICVGFLAAVGAVKGHSWKDLESGIVSGIRNGVQPIIILCLI
GILIGVWEYSGAIPTVTVYALNLIEPQHLLLTALFSCLVISSLVGSSFTTVSTIGVALIGVAAAAGVPLTWAAGAVICGA
CFGDKMSPMSDTTNFAAGVGELPIFKHIRHMAGTTIPALLITILLFFFMGRSLTAAPASTENIQAIINGIEGMVNISVFT
LLSPLLVIVLAVRRTPVIPSLAAGIVSAGIFAALIQPDAGISSFLSAMQNGPVFSADTEAVEKILNRGGLQSMMGSVSLI
IIAFALGGLMEKIGMITSLLEGVIKGIHTKGRLVFSTVSSSIGMNLATGEQYLSILIPGQSFKKLYDKLGIDRKHLSRSL
EDGGTLINPMIPWGVSGAFMSTALGVPVIEYLPFVFFLYLSPLFSILFGFRK
>Mature_451_residues
SNEKRLSFSISALLFMAILFIIFTCLFIFKAEPHIPLLICVGFLAAVGAVKGHSWKDLESGIVSGIRNGVQPIIILCLIG
ILIGVWEYSGAIPTVTVYALNLIEPQHLLLTALFSCLVISSLVGSSFTTVSTIGVALIGVAAAAGVPLTWAAGAVICGAC
FGDKMSPMSDTTNFAAGVGELPIFKHIRHMAGTTIPALLITILLFFFMGRSLTAAPASTENIQAIINGIEGMVNISVFTL
LSPLLVIVLAVRRTPVIPSLAAGIVSAGIFAALIQPDAGISSFLSAMQNGPVFSADTEAVEKILNRGGLQSMMGSVSLII
IAFALGGLMEKIGMITSLLEGVIKGIHTKGRLVFSTVSSSIGMNLATGEQYLSILIPGQSFKKLYDKLGIDRKHLSRSLE
DGGTLINPMIPWGVSGAFMSTALGVPVIEYLPFVFFLYLSPLFSILFGFRK

Specific function: Is a secondary, electrogenic Na(+)/H(+) antiporter that catalyzes Na(+) uptake and proton efflux. Makes modest contributions to pH homeostasis in the alkaline range of pH but is not contributor to Na(+) resistance. Appears to have a repressive effect on g

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 47773; Mature: 47641

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEKRLSFSISALLFMAILFIIFTCLFIFKAEPHIPLLICVGFLAAVGAVKGHSWKDLE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
SGIVSGIRNGVQPIIILCLIGILIGVWEYSGAIPTVTVYALNLIEPQHLLLTALFSCLVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SSLVGSSFTTVSTIGVALIGVAAAAGVPLTWAAGAVICGACFGDKMSPMSDTTNFAAGVG
HHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC
ELPIFKHIRHMAGTTIPALLITILLFFFMGRSLTAAPASTENIQAIINGIEGMVNISVFT
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSPLLVIVLAVRRTPVIPSLAAGIVSAGIFAALIQPDAGISSFLSAMQNGPVFSADTEA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHH
VEKILNRGGLQSMMGSVSLIIIAFALGGLMEKIGMITSLLEGVIKGIHTKGRLVFSTVSS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SIGMNLATGEQYLSILIPGQSFKKLYDKLGIDRKHLSRSLEDGGTLINPMIPWGVSGAFM
HHCCCEECHHHHHEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCEECCCCCCCCCHHHH
STALGVPVIEYLPFVFFLYLSPLFSILFGFRK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNEKRLSFSISALLFMAILFIIFTCLFIFKAEPHIPLLICVGFLAAVGAVKGHSWKDLE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
SGIVSGIRNGVQPIIILCLIGILIGVWEYSGAIPTVTVYALNLIEPQHLLLTALFSCLVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHH
SSLVGSSFTTVSTIGVALIGVAAAAGVPLTWAAGAVICGACFGDKMSPMSDTTNFAAGVG
HHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCC
ELPIFKHIRHMAGTTIPALLITILLFFFMGRSLTAAPASTENIQAIINGIEGMVNISVFT
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSPLLVIVLAVRRTPVIPSLAAGIVSAGIFAALIQPDAGISSFLSAMQNGPVFSADTEA
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHH
VEKILNRGGLQSMMGSVSLIIIAFALGGLMEKIGMITSLLEGVIKGIHTKGRLVFSTVSS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SIGMNLATGEQYLSILIPGQSFKKLYDKLGIDRKHLSRSLEDGGTLINPMIPWGVSGAFM
HHCCCEECHHHHHEEEECCHHHHHHHHHHCCCHHHHHHHHHCCCCEECCCCCCCCCHHHH
STALGVPVIEYLPFVFFLYLSPLFSILFGFRK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10903309; 11274110 [H]