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The map label for this gene is purE [H]

Identifier: 52784494

GI number: 52784494

Start: 697077

End: 697565

Strand: Direct

Name: purE [H]

Synonym: BLi00693

Alternate gene names: 52784494

Gene position: 697077-697565 (Clockwise)

Preceding gene: 52784493

Following gene: 52784495

Centisome position: 16.51

GC content: 52.97

Gene sequence:

>489_bases
ATGCAGCCTCTTCTTGGTGTTATCATGGGAAGCACATCTGACTGGGAAACGATGAAACATGCCTGCGGCATACTCGATGA
ACTGGGAATTCCGTTCGAAAAAAAGGTCGTTTCCGCACATCGGACGCCTGATTTAATGTTTGAATATGCCGAAAAGGCTC
GGGAAAGAGGCTTGAAAGTCATCATTGCCGGAGCGGGCGGAGCCGCTCACCTGCCGGGAATGGTCGCAGCCAAAACGACG
CTGCCCGTCATCGGTGTGCCGGTTCAGTCAAAAGCGCTGAACGGTCTCGATTCGCTGCTTTCAATCGTTCAAATGCCGGG
CGGAGTACCCGTTGCGACCGTTGCCATCGGCAAAGCGGGAGCGGTCAACGCAGGACTGCTTGCGGCGCAGATTTTGTCAG
CTTTTGACAAAGAGCTTGCCGAAAGATTGGACGAACGAAGGGAAAGCATCAGACAAACCGTGTTGGAAAGCAGTGATCAG
CTTGTATAA

Upstream 100 bases:

>100_bases
ATACACGCGCCATGCCCGGTTTGTGTTGCTTCCTACAAATGCAATACATGCCGGGCTTTTTATTTGCGAAGAATAACAGC
TAAAGGTGGGACAAAAGGAT

Downstream 100 bases:

>100_bases
ACAAACGATTTTTCCGGGAGCGACAATCGGCATTATCGGAGGCGGACAGCTGGGCAAAATGATGGCCGTCGCGGCCAAAC
AAATGGGCTATAAAATCGCG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MQPLLGVIMGSTSDWETMKHACGILDELGIPFEKKVVSAHRTPDLMFEYAEKARERGLKVIIAGAGGAAHLPGMVAAKTT
LPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAGAVNAGLLAAQILSAFDKELAERLDERRESIRQTVLESSDQ
LV

Sequences:

>Translated_162_residues
MQPLLGVIMGSTSDWETMKHACGILDELGIPFEKKVVSAHRTPDLMFEYAEKARERGLKVIIAGAGGAAHLPGMVAAKTT
LPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAGAVNAGLLAAQILSAFDKELAERLDERRESIRQTVLESSDQ
LV
>Mature_162_residues
MQPLLGVIMGSTSDWETMKHACGILDELGIPFEKKVVSAHRTPDLMFEYAEKARERGLKVIIAGAGGAAHLPGMVAAKTT
LPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAGAVNAGLLAAQILSAFDKELAERLDERRESIRQTVLESSDQ
LV

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=155, Percent_Identity=62.5806451612903, Blast_Score=164, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324702, Length=145, Percent_Identity=58.6206896551724, Blast_Score=171, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17039; Mature: 17039

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLLGVIMGSTSDWETMKHACGILDELGIPFEKKVVSAHRTPDLMFEYAEKARERGLKV
CCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAG
EEECCCCCHHCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
AVNAGLLAAQILSAFDKELAERLDERRESIRQTVLESSDQLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQPLLGVIMGSTSDWETMKHACGILDELGIPFEKKVVSAHRTPDLMFEYAEKARERGLKV
CCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEE
IIAGAGGAAHLPGMVAAKTTLPVIGVPVQSKALNGLDSLLSIVQMPGGVPVATVAIGKAG
EEECCCCCHHCCCHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
AVNAGLLAAQILSAFDKELAERLDERRESIRQTVLESSDQLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]