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The map label for this gene is aroK

Identifier: 52784193

GI number: 52784193

Start: 348091

End: 348624

Strand: Direct

Name: aroK

Synonym: BLi00371

Alternate gene names: 52784193

Gene position: 348091-348624 (Clockwise)

Preceding gene: 52784192

Following gene: 52784194

Centisome position: 8.24

GC content: 42.32

Gene sequence:

>534_bases
ATGAATGCCGCAATAAGAGATAAGAATATTGTGCTGATCGGGTTTATGGGCGTCGGAAAAACAACCATCGGCCAGCTTGT
GTCAAAGAAATTAGGCCGTGACTTTATCGATATCGACCACGAGATCGAAAAAGACTTTCAAATGACCATTCCGGAGATGT
TTCAGCAAAAAGGGGAAGCGTTTTTCAGACAGACGGAAAAAGAATATATTTTTCAGATGTGCGAACATACAATGGGCAAC
ATCGTATCCTTAGGGGGCGGCGCTTTTCAGCAGGAGGAAATCAGAAAGAAGTGCCTCGAACACTGCTTTGTCATCTTTCT
TGATTTAAGATGGGAGAATTGGAAGCAGCGGATGGATCTCTTGATTGAAAACAGGCCGGTTCTTCATAACCGCACAATTG
AAGAAATGAAACAGCTGTTCAATGAAAGAAAGAGCATTTATGCATTTCACCATTTAAAAGTGGAAACCGATAACCGGTCT
GCCGAAGAAACGGCCGACTATATTGTGGAGATGCTAAAGCTTGGTCAATCTTAA

Upstream 100 bases:

>100_bases
CCTCTTTTTTTATTAACAGGCACCCTATATCATTACAGATGGAATTGTCATATACTTAAGATATTTGATTCCTTTATGCA
GGGAGGAGTAGAAGCTGGAA

Downstream 100 bases:

>100_bases
ACAAACGTTTAATTAAGCTAAATATACCGGAATAAGCAAAGAGCCAATGGTCTGTCTGATCATTGGCTCTTTCCGTTATC
CGCAGATGAATGCCGGATTT

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MNAAIRDKNIVLIGFMGVGKTTIGQLVSKKLGRDFIDIDHEIEKDFQMTIPEMFQQKGEAFFRQTEKEYIFQMCEHTMGN
IVSLGGGAFQQEEIRKKCLEHCFVIFLDLRWENWKQRMDLLIENRPVLHNRTIEEMKQLFNERKSIYAFHHLKVETDNRS
AEETADYIVEMLKLGQS

Sequences:

>Translated_177_residues
MNAAIRDKNIVLIGFMGVGKTTIGQLVSKKLGRDFIDIDHEIEKDFQMTIPEMFQQKGEAFFRQTEKEYIFQMCEHTMGN
IVSLGGGAFQQEEIRKKCLEHCFVIFLDLRWENWKQRMDLLIENRPVLHNRTIEEMKQLFNERKSIYAFHHLKVETDNRS
AEETADYIVEMLKLGQS
>Mature_177_residues
MNAAIRDKNIVLIGFMGVGKTTIGQLVSKKLGRDFIDIDHEIEKDFQMTIPEMFQQKGEAFFRQTEKEYIFQMCEHTMGN
IVSLGGGAFQQEEIRKKCLEHCFVIFLDLRWENWKQRMDLLIENRPVLHNRTIEEMKQLFNERKSIYAFHHLKVETDNRS
AEETADYIVEMLKLGQS

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Homo sapiens, GI153792148, Length=172, Percent_Identity=29.0697674418605, Blast_Score=70, Evalue=7e-13,
Organism=Escherichia coli, GI87082255, Length=169, Percent_Identity=33.1360946745562, Blast_Score=89, Evalue=2e-19,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_BACLD (Q65NN5)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_077613.1
- RefSeq:   YP_090022.1
- ProteinModelPortal:   Q65NN5
- SMR:   Q65NN5
- STRING:   Q65NN5
- EnsemblBacteria:   EBBACT00000054527
- EnsemblBacteria:   EBBACT00000061062
- GeneID:   3029308
- GeneID:   3100033
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00371
- KEGG:   bli:BL01707
- NMPDR:   fig|279010.5.peg.2224
- eggNOG:   COG0703
- GeneTree:   EBGT00050000003023
- HOGENOM:   HBG335815
- OMA:   LYNERLS
- ProtClustDB:   PRK00131
- BioCyc:   BLIC279010-1:BLI00371-MONOMER
- BioCyc:   BLIC279010:BL01707-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 20878; Mature: 20878

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 39-39 BINDING 63-63 BINDING 86-86 BINDING 125-125 BINDING 143-143 BINDING 159-159

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAIRDKNIVLIGFMGVGKTTIGQLVSKKLGRDFIDIDHEIEKDFQMTIPEMFQQKGEA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
FFRQTEKEYIFQMCEHTMGNIVSLGGGAFQQEEIRKKCLEHCFVIFLDLRWENWKQRMDL
HHHHHHHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LIENRPVLHNRTIEEMKQLFNERKSIYAFHHLKVETDNRSAEETADYIVEMLKLGQS
HHCCCCCHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNAAIRDKNIVLIGFMGVGKTTIGQLVSKKLGRDFIDIDHEIEKDFQMTIPEMFQQKGEA
CCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
FFRQTEKEYIFQMCEHTMGNIVSLGGGAFQQEEIRKKCLEHCFVIFLDLRWENWKQRMDL
HHHHHHHHHHHHHHHHHHHCEECCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LIENRPVLHNRTIEEMKQLFNERKSIYAFHHLKVETDNRSAEETADYIVEMLKLGQS
HHCCCCCHHHCCHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA