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The map label for this gene is opuE [H]

Identifier: 52144101

GI number: 52144101

Start: 1231950

End: 1233428

Strand: Reverse

Name: opuE [H]

Synonym: BCZK1128

Alternate gene names: 52144101

Gene position: 1233428-1231950 (Counterclockwise)

Preceding gene: 52144088

Following gene: 52144100

Centisome position: 23.27

GC content: 37.53

Gene sequence:

>1479_bases
ATGAGTACGCAGATGTTAACTTTAACTTCTATCTCTATTTACATGCTCGGGATGTTAGTAATTGGCTATTTTGCCTATAA
ACGAACGTCCAACTTAACAGATTATATGCTTGGCGGGCGTACACTAGGTCCCGCAGTAACGGCATTAAGTGCTGGAGCAT
CCGATATGAGTGGTTGGCTTTTAATGGGCTTACCCGGTGCAATGTTTAGCGTTGGATTAAGTAGTAGTTGGATTGCGATC
GGCCTAACACTAGGCGCATACGCAAACTGGCTATATGTCGCTCCTCGCTTACGTACCTACTCAGAAATTGCAAACAACTC
TATTACTATCCCAGAATTTTTGGAACATCGCTTCCAAGACAAATCCCATATGCTACGCTTAGTATCTGGACTTGTTATTA
TGATTTTCTTTACTTTTTATGTAGCTTCAGGATTAGTTTCAGGCGCTGTATTATTTGAAAATTCATTTGGTATGAACTAC
CATGTTGGATTATTCATTGTTGCAGGCGTTGTTGTAGCTTACACGTTATTTGGGGGTTTCTTAGCAGTAAGTTGGACAGA
CTTCGTGCAAGGAATCATTATGGTGATTGCTCTTATTCTTGTTCCTACTGTTACAATTATGAATGTAAATGGGCTTGGTC
CAGCATTTAGCACAATTAAATCAATTGATCCAACATTATTAGACATTTTTAAAGGCACTTCTGTATTAGGTATTATTTCA
TTATTCGCATGGGGCCTTGGTTATGTTGGACAACCACATATTATCGTACGCTTTATGGCGATTTCTTCTGTAAAAGAAAT
TAAAAGTGCAAGACGAATTGGTATGAGCTGGATGATTTTCTCTGTTGTCGGAGCTATGTTTACTGGTCTTATCGGTATTG
CATACTACTCAGACAAAGGATTAAAACTATCCAATCCAGAGACAATTTTCCTTGAACTGGGAAAAATTTTATTCCACCCA
CTTATTACTGGATTTTTATTAGCCGCTATTTTAGCAGCGATTATGAGTACAATCTCATCTCAGTTACTCGTGACTTCTAG
TGCCATAACTGAAGACTTATATCGTACTTTCTTTAAACGTTCTGCTTCTGATAAAGAGCTTGTATTTGTCGGCCGTATGG
CTGTACTTGTTATTGCATTAGTTGGATGTACATTAGCGTTTAAACAAAATGATACGATTTTAGCTCTTGTTGGATACGCT
TGGGCTGGATTTGGCTCTTCATTCGGACCTGCTATTTTATTAAGCTTATATTGGAAACGTATGACGAAGTGGGGCGCACT
TGCTGGTATGATTTCTGGTGCCGCTACAGTCATTATTTGGACTCAATTCAAATTCTTAAAAGAATCCTTATATGAAATGA
TTCCTGGTTTCACTATTAGTTTACTAGTAATCGTAATTGTTAGTTTACTAACACAGCCTTCAAAAGAAATTGAAGATCAA
TTTGAGGATTTCGAAAAACAACATAGTGATAATCTATAA

Upstream 100 bases:

>100_bases
CTGAAAATTCATATTTCTATATGGATTTTTCAGAATAATCATGATAGATTATAAATATGCATAACGCATCAAAAGACATG
ACAAAAGGAAGGGGAACTAC

Downstream 100 bases:

>100_bases
AGGAAAAGCTCTGCTGTTATGATAGCAGAGCTTTCTTTTTATCCCGCTATTTGTTGGCAATAAGACCCACACCTCAAAAT
TCGGCGAATACGAAGGCGTT

Product: sodium/proline symporter; osmoregulated proline transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAI
GLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNY
HVGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKGLKLSNPETIFLELGKILFHP
LITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCTLAFKQNDTILALVGYA
WAGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKESLYEMIPGFTISLLVIVIVSLLTQPSKEIEDQ
FEDFEKQHSDNL

Sequences:

>Translated_492_residues
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAI
GLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNY
HVGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKGLKLSNPETIFLELGKILFHP
LITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCTLAFKQNDTILALVGYA
WAGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKESLYEMIPGFTISLLVIVIVSLLTQPSKEIEDQ
FEDFEKQHSDNL
>Mature_491_residues
STQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAIG
LTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYH
VGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIISL
FAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKGLKLSNPETIFLELGKILFHPL
ITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCTLAFKQNDTILALVGYAW
AGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKESLYEMIPGFTISLLVIVIVSLLTQPSKEIEDQF
EDFEKQHSDNL

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=491, Percent_Identity=54.5824847250509, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI110835708, Length=553, Percent_Identity=23.869801084991, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI206597483, Length=438, Percent_Identity=24.8858447488584, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI206597487, Length=438, Percent_Identity=24.8858447488584, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4507031, Length=553, Percent_Identity=22.0614828209765, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI109659836, Length=442, Percent_Identity=22.1719457013575, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI14140236, Length=543, Percent_Identity=22.2836095764273, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI109659839, Length=460, Percent_Identity=22.1739130434783, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4507035, Length=364, Percent_Identity=26.6483516483516, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4507033, Length=413, Percent_Identity=24.6973365617433, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI11141885, Length=459, Percent_Identity=24.6187363834423, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1787251, Length=493, Percent_Identity=54.3610547667343, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI87082237, Length=442, Percent_Identity=28.2805429864253, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790503, Length=501, Percent_Identity=25.5489021956088, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1790113, Length=391, Percent_Identity=24.2966751918159, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115533094, Length=387, Percent_Identity=24.2894056847545, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539284, Length=474, Percent_Identity=22.5738396624473, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24645928, Length=383, Percent_Identity=26.8929503916449, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221459584, Length=370, Percent_Identity=22.7027027027027, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI221459588, Length=398, Percent_Identity=24.8743718592965, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221459586, Length=385, Percent_Identity=25.1948051948052, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640370, Length=353, Percent_Identity=23.7960339943343, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24650192, Length=411, Percent_Identity=22.6277372262774, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221459582, Length=372, Percent_Identity=24.4623655913978, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651739, Length=349, Percent_Identity=25.214899713467, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573698, Length=408, Percent_Identity=23.5294117647059, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281362918, Length=289, Percent_Identity=25.9515570934256, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24651741, Length=183, Percent_Identity=31.6939890710383, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI19920916, Length=402, Percent_Identity=24.6268656716418, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53660; Mature: 53529

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWL
CCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEE
LMGLPGAMFSVGLSSSWIAIGLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQD
EECCCHHHHHHCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCHHHHHHHHHCC
KSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYHVGLFIVAGVVVAYTLFGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHH
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
LKLSNPETIFLELGKILFHPLITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SASDKELVFVGRMAVLVIALVGCTLAFKQNDTILALVGYAWAGFGSSFGPAILLSLYWKR
CCCCCCEEHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHHCCCCCCHHHHHHHHHHHH
MTKWGALAGMISGAATVIIWTQFKFLKESLYEMIPGFTISLLVIVIVSLLTQPSKEIEDQ
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHH
FEDFEKQHSDNL
HHHHHHHHCCCC
>Mature Secondary Structure 
STQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWL
CCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEE
LMGLPGAMFSVGLSSSWIAIGLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFQD
EECCCHHHHHHCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCHHHHHHHHHCC
KSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYHVGLFIVAGVVVAYTLFGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LAVSWTDFVQGIIMVIALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHH
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSDKG
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCC
LKLSNPETIFLELGKILFHPLITGFLLAAILAAIMSTISSQLLVTSSAITEDLYRTFFKR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SASDKELVFVGRMAVLVIALVGCTLAFKQNDTILALVGYAWAGFGSSFGPAILLSLYWKR
CCCCCCEEHHHHHHHHHHHHHHHHHEEECCCCEEEEHHHHHHCCCCCCHHHHHHHHHHHH
MTKWGALAGMISGAATVIIWTQFKFLKESLYEMIPGFTISLLVIVIVSLLTQPSKEIEDQ
HHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHH
FEDFEKQHSDNL
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]