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The map label for this gene is lldP [H]

Identifier: 52144090

GI number: 52144090

Start: 1241229

End: 1242728

Strand: Direct

Name: lldP [H]

Synonym: BCZK1139

Alternate gene names: 52144090

Gene position: 1241229-1242728 (Clockwise)

Preceding gene: 52144091

Following gene: 52144089

Centisome position: 23.42

GC content: 36.6

Gene sequence:

>1500_bases
ATGGCCATATTGTTGGCACTTATCCCAATTATGATGATTTTCATTTGTTTATTTTTATTTAAACAAACGTCATTAAGATC
CTCGTTAATTTCTTATGCGGTATGTGTTGGAATCGTTTTACTCTCGCCAACGTTTCAATTAGGGATAAGTGAAACTGTGC
ACGCAACAATTAAAGGATGGTTAATTTGTTTTATTGTCGGGTACGTTTTATTTTTCGGTATTTTTTTATTTCACCTCATG
AATAAAATGGGGTACATCGACCAAGTAGCACGTTTTCTAGAAGAGGTTACGTATGATCGTTTATTACAAATGCTGCTTAT
GTGTTTTGGTATTTGTCCACTAATTGAATCAGTAAGTGGATTCGGAATCGGCTTTATGGTTGCAGCACCTATTTTTCTTT
CATTAGGCTATAAACCGTTTCAAGCTGTACTGCTCTCTTTTATCGGTTTACTAGCTAGTTCATGGGGCGCAATGGCAACT
GGTACGATTATCGGTTCCCAGCTCATCAATATGCCGCTTACAACACTCGGTACAAATACAGCGCTATTAAGTATCCCGAT
GTTCGCTTATTTCGTCATTCTTTCTTTACATGTTGTTGGTGGCTGGCAGGCGGTTATTGAAAAGTGGAAGGAAGGATTCG
GCTTCTTTCTATTATTTTCTCTCGGAATCTATCTTTCTAACGCATACGTAAGTGTTGAACTCGCAGGTATATTAAGTTCT
ATCGTTACAATTACATTTGGCTTTCTTATCATTAAACTAAAAGGGAAAAATGAACAAAATCTAATGACAGAACATGCTGC
GGCAACGGAAAGAGAAGTATCTATTATAAAAATTATTAGCCCTTATATATTCTTAACCGTTTGTATTTTACTTTCTCGCC
TCGTACCAGTATTGCATGATGTATTTAGATCATATGCGGTTCTTGATTTAAAATCATACTCTTACAAATTAGAAATGCTG
TATTCACCAGGATTTTGGCTCGGTATGACTTGTTTATTTACTATTATTTTCTTCCGCATTCCATCTCATATTATGAAACA
ATCACTTTTACAAACGATAAAACAATGGATCCCGTTCGCTATTACAACGACAATGTTTATTGCTATTTCAGAACTAATGG
GCGCATCTGGCATGCATGCATTACTAGCAAAAACAGCTGGTGACACATTTGGAACATTTTTTGTTTTCGTTGCTCCGTTT
ATTGGTGGTATCGGTGGCTTTTTAACAGGTAGTAATGCAGGATCAAATGCGATGTTCATAAAACTACAAATGCAAACGGC
GCAAAATGTAGCACTCCCGTGGCAATACGTCACAACACTGCAAAATACTGCATCATCAGTAGCGACAATTGCTTGCCCAT
CACGGATTACACTAGGTGCGTATTTATGTAACATCCCGTATCGTGAAAATGAACTATTAAAGAAGGCGACGTTAATGATT
TTTGGTGCGGTATTACTTATAGTAGTGGAAGTTATTTTCTGGTATATGTTGAGAAATTAA

Upstream 100 bases:

>100_bases
AAACGGCTCTTTTTTGAAACTGTTGTAAAAACAATTGAAAATTATGACATCTGTTATATAATAGTTAAAAATTGTATTTT
AAACGAAATGAGATGATAAC

Downstream 100 bases:

>100_bases
AAATTCTCCTATATTTAGGAGGATTTTTTTTGTTACTGGATAATGCTTTAAATTATGAAAAGCTGCTACTAAATGAATAG
GAGATGAAATGTATGGCCCT

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEEVTYDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKLKGKNEQNLMTEHAAATEREVSIIKIISPYIFLTVCILLSRLVPVLHDVFRSYAVLDLKSYSYKLEML
YSPGFWLGMTCLFTIIFFRIPSHIMKQSLLQTIKQWIPFAITTTMFIAISELMGASGMHALLAKTAGDTFGTFFVFVAPF
IGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKATLMI
FGAVLLIVVEVIFWYMLRN

Sequences:

>Translated_499_residues
MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLM
NKMGYIDQVARFLEEVTYDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMAT
GTIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSS
IVTITFGFLIIKLKGKNEQNLMTEHAAATEREVSIIKIISPYIFLTVCILLSRLVPVLHDVFRSYAVLDLKSYSYKLEML
YSPGFWLGMTCLFTIIFFRIPSHIMKQSLLQTIKQWIPFAITTTMFIAISELMGASGMHALLAKTAGDTFGTFFVFVAPF
IGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKATLMI
FGAVLLIVVEVIFWYMLRN
>Mature_498_residues
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMN
KMGYIDQVARFLEEVTYDRLLQMLLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATG
TIIGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLGIYLSNAYVSVELAGILSSI
VTITFGFLIIKLKGKNEQNLMTEHAAATEREVSIIKIISPYIFLTVCILLSRLVPVLHDVFRSYAVLDLKSYSYKLEMLY
SPGFWLGMTCLFTIIFFRIPSHIMKQSLLQTIKQWIPFAITTTMFIAISELMGASGMHALLAKTAGDTFGTFFVFVAPFI
GGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITLGAYLCNIPYRENELLKKATLMIF
GAVLLIVVEVIFWYMLRN

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=517, Percent_Identity=21.2765957446809, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789347, Length=316, Percent_Identity=23.4177215189873, Blast_Score=72, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 55261; Mature: 55130

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AILLALIPIMMIFICLFLFKQTSLRSSLISYAVCVGIVLLSPTFQLGISETVHATIKGW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHH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HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]