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The map label for this gene is ilvC [H]

Identifier: 52143945

GI number: 52143945

Start: 1377258

End: 1378268

Strand: Direct

Name: ilvC [H]

Synonym: BCZK1284

Alternate gene names: 52143945

Gene position: 1377258-1378268 (Clockwise)

Preceding gene: 52143946

Following gene: 52143944

Centisome position: 25.98

GC content: 41.05

Gene sequence:

>1011_bases
ATGGCAAAAGTTTATTATGAAAAAGATGTAACGGTAAATGTATTAAAGGAAAAGAAAGTAGCAATCATTGGATATGGCTC
GCAAGGTCATGCACATGCGCAAAATTTACGTGATAACGGATTTGATGTAGTAGTAGGTTTAAGAAAAGGTAAGTCTTGGG
ATAAAGCGAAAGAAGATGGATTTTCTGTATATACAGTAGCAGAAGCAGCAAAGCAGGCTGATGTAGTAATGATTTTGCTG
CCAGATGAACTGCAACCAGAAGTATATGAAGCGGAAATTGCGCCAAATTTACAGGCAGGAAATTCTCTCGTTTTTGCACA
CGGATTTAATGTTCACTTTGATCAAGTGAAACCACCAGCGAATGTAGATGTATTTCTAGTAGCGCCAAAAGGGCCAGGTC
ATCTTGTGCGCCGTACATTTAGTGAGGGCGGTGCTGTTCCTGCATTATTTGCCGTATATCAAGATGCAACAGGAGTTGCG
ACTGAAAAGGCACTTTCTTATGCCGATGGAATTGGAGCGACGAGAGCTGGTGTATTAGAAACGACATTTAAAGAAGAAAC
GGAAACAGATTTATTTGGAGAGCAAGCTGTACTTTGCGGCGGAGTAACTGCGCTAGTCAAAGCTGGATTTGAAACGTTAG
TTGATGCCGGATATCAGCCGGAACTTGCATATTTTGAATGTTTACATGAACTGAAACTTATTGTTGACCTTATGTATGAA
GGTGGACTTGAAAATATGAGATATTCAGTTTCAGATACAGCGCAGTGGGGCGACTTCGTATCAGGACCACGTGTTGTAAC
AGAAGATACGAAGAAAGCGATGGGTGCAGTGTTAGCAGAAATTCAAGATGGTACATTTGCAAGAGGTTGGATTGCAGAAC
ATAAAGCAGGAAGACCGAATTTCCATGCGACAAATGAGAAAGAAAATGAACATGAAATCGAAGTAGTTGGACGTAAATTA
CGTGAAATGATGCCTTTCGTACAGCCGCGAGTAAAGGCAGGGGTCAAATAA

Upstream 100 bases:

>100_bases
TTGCAAGAACAGGTGTAACAGCCTTTACGCGTAGTATGAAAAAGCAAGATAAGCAAGTAATGTTAATTCAATAATCATTT
AAATATAGGGGGAAATGAAA

Downstream 100 bases:

>100_bases
TATGAAGAAAATTTTGTTCATGGATACGACGCTACGTGATGGCGAACAATCACCAGGAGTAAATTTAAATGAACAAGAGA
AATTGCAAATTGCAAGGCAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase 1; Alpha-keto-beta-hydroxylacil reductoisomerase 1 [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILL
PDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPANVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENEHEIEVVGRKL
REMMPFVQPRVKAGVK

Sequences:

>Translated_336_residues
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILL
PDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPANVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVA
TEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENEHEIEVVGRKL
REMMPFVQPRVKAGVK
>Mature_335_residues
AKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKQADVVMILLP
DELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPANVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVAT
EKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEG
GLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENEHEIEVVGRKLR
EMMPFVQPRVKAGVK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=34.8122866894198, Blast_Score=144, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323387, Length=333, Percent_Identity=35.1351351351351, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36651; Mature: 36520

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDG
CCEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHCC
FSVYTVAEAAKQADVVMILLPDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPA
CEEEEHHHHHHCCCEEEEEECCCCCCCCEEHHCCCCCCCCCEEEEEECCEEECCCCCCCC
NVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPN
CCCCCCEECCCCCHHHCHHCCCCEEECHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCC
FHATNEKENEHEIEVVGRKLREMMPFVQPRVKAGVK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure 
AKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDG
CEEEEECCCEEEEECCCEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHCC
FSVYTVAEAAKQADVVMILLPDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPA
CEEEEHHHHHHCCCEEEEEECCCCCCCCEEHHCCCCCCCCCEEEEEECCEEECCCCCCCC
NVDVFLVAPKGPGHLVRRTFSEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLE
CCEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHH
TTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYE
HHHHHHHHHHHCCCCHHHHCCHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMGAVLAEIQDGTFARGWIAEHKAGRPN
CCCCCCEECCCCCHHHCHHCCCCEEECHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCC
FHATNEKENEHEIEVVGRKLREMMPFVQPRVKAGVK
CCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]