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The map label for this gene is hisH [H]

Identifier: 52143936

GI number: 52143936

Start: 1386955

End: 1387584

Strand: Direct

Name: hisH [H]

Synonym: BCZK1293

Alternate gene names: 52143936

Gene position: 1386955-1387584 (Clockwise)

Preceding gene: 52143937

Following gene: 52143935

Centisome position: 26.16

GC content: 35.24

Gene sequence:

>630_bases
TTGATTGCCATTATAGATTATGGAATGGGAAATATTCGTAGTGTAGAACAAGCATTAAAATACATTGGAGCAGCGTACAT
CGTAACGAGTGATAAAGAAGAGATTTTTAGAAGTGATGGAGTGATTTTACCAGGAGTAGGTGCATTTCCAAAAGCGATGG
ATATATTGGAAGAAAAAGATTTAGTTCGTGTGTTACAAGAAATTGGGCGTTCAAGAAAACCACTTCTAGGCATTTGCTTA
GGAATGCAGCTTTTATTTGAAAAAAGTGAGGAACTCCAAGATTGTAACGGATTAAGTTTATTGCCAGGTGTTATTCGAAA
GTTAAAAGTTCCTTATAAAATTCCTCATATGGGATGGAATGAGTTAAAGAAAGAAGGAGAAATAGCGCTTTGGAATGGAG
TAGAGGACGGTTCTTTCGTATATTATGTCCACTCTTATTACGCAGATTGTCCAAATGAAATTGTGTATGGAATAAGTGAT
TATGGAGTGAAAGTACCTGGTTTTGTAGCAAAAGGAAATATATATGGTGCACAGTTTCATCCTGAAAAAAGTGGTGACAT
TGGCATGCAAATATTGAAAAATTTTAAAGGAGTGGTAGAAACATGGAAATCTTCCCAGCTATCGATTTAA

Upstream 100 bases:

>100_bases
AATTGAAGCATTATTTAAAGCGTTTGGTAGAGCGCTTAGAGAAGCAGTCGAAAGAAATGCCCACATTACTGGTGTAAATT
CAACGAAAGGGATGTTGTAA

Downstream 100 bases:

>100_bases
AAGAAGGGCGATGCGTTAGACTGTATCAAGGCGAGTTTAGTAAAGAAACAGTAATGAATGAAGACCCGGTTGCGCAAGCT
ATTATATTCGAAAAGTTTGG

Product: imidazole glycerol phosphate synthase subunit HisH

Products: NA

Alternate protein names: IGP synthase glutamine amidotransferase subunit; IGP synthase subunit hisH; ImGP synthase subunit hisH; IGPS subunit hisH [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIAIIDYGMGNIRSVEQALKYIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDILEEKDLVRVLQEIGRSRKPLLGICL
GMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISD
YGVKVPGFVAKGNIYGAQFHPEKSGDIGMQILKNFKGVVETWKSSQLSI

Sequences:

>Translated_209_residues
MIAIIDYGMGNIRSVEQALKYIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDILEEKDLVRVLQEIGRSRKPLLGICL
GMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISD
YGVKVPGFVAKGNIYGAQFHPEKSGDIGMQILKNFKGVVETWKSSQLSI
>Mature_209_residues
MIAIIDYGMGNIRSVEQALKYIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDILEEKDLVRVLQEIGRSRKPLLGICL
GMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWNELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISD
YGVKVPGFVAKGNIYGAQFHPEKSGDIGMQILKNFKGVVETWKSSQLSI

Specific function: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR [H]

COG id: COG0118

COG function: function code E; Glutamine amidotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788334, Length=200, Percent_Identity=39.5, Blast_Score=134, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6319725, Length=208, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010139
- InterPro:   IPR016226 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 23268; Mature: 23268

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIIDYGMGNIRSVEQALKYIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDILEEKD
CEEEEECCCCCHHHHHHHHHHHCEEEEEECCHHHHHHCCCEEECCCCCCHHHHHHHHHHH
LVRVLQEIGRSRKPLLGICLGMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEECCCCCHH
ELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISDYGVKVPGFVAKGNIYGAQFH
HHHCCCCEEEECCCCCCCEEEEEEHHHHCCCHHHEECHHHCCEECCCEEECCCEEECEEC
PEKSGDIGMQILKNFKGVVETWKSSQLSI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIAIIDYGMGNIRSVEQALKYIGAAYIVTSDKEEIFRSDGVILPGVGAFPKAMDILEEKD
CEEEEECCCCCHHHHHHHHHHHCEEEEEECCHHHHHHCCCEEECCCCCCHHHHHHHHHHH
LVRVLQEIGRSRKPLLGICLGMQLLFEKSEELQDCNGLSLLPGVIRKLKVPYKIPHMGWN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEECCCCCHH
ELKKEGEIALWNGVEDGSFVYYVHSYYADCPNEIVYGISDYGVKVPGFVAKGNIYGAQFH
HHHCCCCEEEECCCCCCCEEEEEEHHHHCCCHHHEECHHHCCEECCCEEECCCEEECEEC
PEKSGDIGMQILKNFKGVVETWKSSQLSI
CCCCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Glycosyltransferases; Pentosyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA