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The map label for this gene is czcD [H]

Identifier: 52143653

GI number: 52143653

Start: 1662435

End: 1663334

Strand: Direct

Name: czcD [H]

Synonym: BCZK1581

Alternate gene names: 52143653

Gene position: 1662435-1663334 (Clockwise)

Preceding gene: 52143655

Following gene: 52143649

Centisome position: 31.36

GC content: 35.22

Gene sequence:

>900_bases
ATGGGACATTCACATGATCATGGTCATTCCAAAAATAAAAAGGCATTACTACTTGCATTCTTACTAACAACAAGTTTTAT
GATTGCTGAAGTTATTGGGGGATTTGTAACAAATAGCTTAGCACTACTATCTGACGCGGGGCATATGCTAAGTGATGCAG
TATCTTTAGCTTTAAGTTTACTTGCGTTTAAACTCGGAGAAAAAACAGCAACAACTGCGAAAACATATGGATATAAGCGA
GTCGAAATGTTAGCGGCATTATGTAACGGTGTCGTCCTTATTGTCATTTCAATATACATTTTTATTGAAGCAATTCGCCG
TTTTAAAGAGCCAGTTGAGATTGCTAGTAATGGGATGCTTATTATTGCTGTACTTGGTCTACTTATTAATATTTTATCAG
CTTGGATATTAATGAGAGGCGGAGATGTAAAGGGGAATTTAAATTTAAGAAGTGCTTTTTTACACGTATTAGGCGATCTA
TTAGGATCAGTTGGAGCGATTATTGCTGCGTTACTTATTAAATTTTTCGGATGGACTGCTGCAGATGCGATTGCTAGTAT
TCTTGTGTCTATTTTAGTCATTATTAGTGGATGGCGTGTAACACGTGATACGGTCCATATATTAATGGAAGGTGCACCGC
AGAACATAAATGTTGAAGAGGTAAAAAGTACATTGTTAAATATTACGATTGTAAAAGAAGTTCATGATTTGCACGTATGG
TCTGTCACATCGGATTTTCAAGTATTAACTTGCCACTTGATTATTAAAGGAAATGAAACACAAAGTGTATTAAAAGAGGC
TACGGAAGTATTAAAAGAGAAGTTTCATGTAGAACATGTCACCATTCAAGTAGAAATAGATGGTGAATTTCATCATAGTG
AGACAACTTGCAAAGTATGA

Upstream 100 bases:

>100_bases
GTTTGAAAAGTATCGAAGTGTGTATACAGAGGAAGCGGGATAAAGACAGGGAGTTTGTTTCATACTAACATACAGATATA
GCACTTAAAGGAGTATAAGT

Downstream 100 bases:

>100_bases
AAGAAAAAGGATAAGAAAAAGTGTCATAACATTTTTCGCGCGGCATACATATATATAATGTGGCCACAAATACTTTGTAA
GGTAAATATTTCATGAAATT

Product: cobalt-zinc-cadmium resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MGHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATTAKTYGYKR
VEMLAALCNGVVLIVISIYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDL
LGSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQNINVEEVKSTLLNITIVKEVHDLHVW
SVTSDFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV

Sequences:

>Translated_299_residues
MGHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATTAKTYGYKR
VEMLAALCNGVVLIVISIYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDL
LGSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQNINVEEVKSTLLNITIVKEVHDLHVW
SVTSDFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV
>Mature_298_residues
GHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATTAKTYGYKRV
EMLAALCNGVVLIVISIYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLL
GSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQNINVEEVKSTLLNITIVKEVHDLHVWS
VTSDFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=34.5637583892617, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI52352805, Length=305, Percent_Identity=31.8032786885246, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI21359890, Length=305, Percent_Identity=33.7704918032787, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI289803013, Length=269, Percent_Identity=33.457249070632, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI289803009, Length=269, Percent_Identity=33.457249070632, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI289803007, Length=269, Percent_Identity=33.457249070632, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI289803003, Length=269, Percent_Identity=33.457249070632, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI64762489, Length=303, Percent_Identity=32.3432343234323, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI20070323, Length=322, Percent_Identity=27.639751552795, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI14210520, Length=230, Percent_Identity=31.304347826087, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI52351208, Length=132, Percent_Identity=39.3939393939394, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=41.1290322580645, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI222080086, Length=128, Percent_Identity=29.6875, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI40255009, Length=128, Percent_Identity=29.6875, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=47.4820143884892, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1790349, Length=218, Percent_Identity=22.0183486238532, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17555794, Length=318, Percent_Identity=36.1635220125786, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI193210990, Length=326, Percent_Identity=33.4355828220859, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17555796, Length=314, Percent_Identity=35.3503184713376, Blast_Score=177, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI32564488, Length=312, Percent_Identity=28.525641025641, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=39.4444444444444, Blast_Score=106, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6323899, Length=122, Percent_Identity=39.344262295082, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=123, Percent_Identity=39.0243902439024, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583858, Length=338, Percent_Identity=31.0650887573964, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24656728, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656724, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656720, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656715, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21357035, Length=339, Percent_Identity=30.9734513274336, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24585900, Length=150, Percent_Identity=39.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585898, Length=150, Percent_Identity=39.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585896, Length=150, Percent_Identity=39.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921672, Length=150, Percent_Identity=39.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=32.3943661971831, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=32.3943661971831, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24645863, Length=125, Percent_Identity=36.8, Blast_Score=81, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32581; Mature: 32450

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFKLGEKTATTAKTYGYKRVEMLAALCNGVVLIVISIYIFIEAIRRFKEPVEIASNGML
HHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSVGAIIAALLIKFFGWTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADAIASILVSILVIISGWRVTRDTVHILMEGAPQNINVEEVKSTLLNITIVKEVHDLHVW
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
SVTSDFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV
EECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEECCCCCCCC
>Mature Secondary Structure 
GHSHDHGHSKNKKALLLAFLLTTSFMIAEVIGGFVTNSLALLSDAGHMLSDAVSLALSL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFKLGEKTATTAKTYGYKRVEMLAALCNGVVLIVISIYIFIEAIRRFKEPVEIASNGML
HHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSVGAIIAALLIKFFGWTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADAIASILVSILVIISGWRVTRDTVHILMEGAPQNINVEEVKSTLLNITIVKEVHDLHVW
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEE
SVTSDFQVLTCHLIIKGNETQSVLKEATEVLKEKFHVEHVTIQVEIDGEFHHSETTCKV
EECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHCEEEEEEEEEECCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA