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The map label for this gene is cobW [H]

Identifier: 52143650

GI number: 52143650

Start: 1665595

End: 1666782

Strand: Reverse

Name: cobW [H]

Synonym: BCZK1584

Alternate gene names: 52143650

Gene position: 1666782-1665595 (Counterclockwise)

Preceding gene: 52143646

Following gene: 52143651

Centisome position: 31.44

GC content: 33.84

Gene sequence:

>1188_bases
ATGAAAAAAATACCTATCACTGTATTAAGTGGGTTTTTGGGATCCGGAAAAACTACATTACTACATCATATTTTAACTAA
TAAGAACAACTTAAAAGTAGCTGTTATCGTTAATGATATGGGCGAAGTAAACATTGATGCCTCCCTTATAAAAAAAGGTG
GTTTTTCACGTACGGAGGAAAAACTAGTAGAAATTCAAAATGGCTGTATTTGTTGTACACTACGAGAAGATTTAATAATA
GAAGTGAATCGCCTTGTTGAAAACGGTGATATTGACTATATAGTGATTGAATCTTCCGGTATAAGTGAGCCGATTCCAGT
TGCCCAAACATTTACTTATACTGACGACGTTCTTAACATTGATTTAACGAAAAATTGTCGCCTCGATACGATGGTTACAG
TTGTAGATGCAAATAGATTTTGGGATGATTTTGTAGATGGAGAAAGTTTATTAGATCGCAAACAAGCAATCAATGAAAAT
GATAATCGGGAAGTTATTGATTTATTAATAGATCAAATTGAGTTTGCAAATGTAATTATTCTTAATAAGATAGATTTACT
AGAAAAAGAAGATGTGATAGAACTTCATCAACTGCTACAGAAATTAAATCCTAATGCAAAAATTATTGAATCTTCCTTTA
GCAACGTACCACTGCAAGAAATTTTAAATACAAATGTATTCAATTATGAGGAAGCCAGTCAATCGGCGGGCTGGATACAA
GAATTAAATAGTGAACATCATACACCCGAAACGGAAGAATACGGTATCAATTCCTTTGTATACCGTCGTAAATACCCTTT
CCATCCTGAACGCCTTATGAATTGGCTAGGAAAATGGCCTGTAGATGTCGTAAGAGCAAAAGGCTTTTTCTGGCTCGCAT
CTCGTAATAATATGATAGGTCTTCTATCTCAAGCAGGTTCCTCTATTACAATTCAAGGAGCCGGTGAATGGATAGCAGCA
TTACCTGAAACTGAAAGAAATCAAATGATCATAGAAGAGCCAGAAGTATTGAAAAACTGGGATAAACAATATGGAGATCG
AATAACTGAACTCGTATTTATCGGAATTGATATGAACCGTTCTTTAATTGAACAATCATTAGATGATTGTCTATTAACAG
AAAAAGAAATGACACAAAACTGGAATACATTCATTGATCCTATTCCAGCTTTTACTTACACTTCATAA

Upstream 100 bases:

>100_bases
ATTTTTAAATCGTAATTATTATGATTTATCATTGATTTTTTCCTTTCAATCATTTAACATAAAACGTAATCATTACGATT
TAAAGGAGAGAAAGAATTTC

Downstream 100 bases:

>100_bases
TTCAAAACAGAAAGGCTTCCGTAAACGGAAGCCTTTCTATTTTATCGTTCTCTTATTTAACAAACTTCTTTCATTTGAAT
AACAACTTTACATTAAGTAA

Product: cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MKKIPITVLSGFLGSGKTTLLHHILTNKNNLKVAVIVNDMGEVNIDASLIKKGGFSRTEEKLVEIQNGCICCTLREDLII
EVNRLVENGDIDYIVIESSGISEPIPVAQTFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFVDGESLLDRKQAINEN
DNREVIDLLIDQIEFANVIILNKIDLLEKEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQ
ELNSEHHTPETEEYGINSFVYRRKYPFHPERLMNWLGKWPVDVVRAKGFFWLASRNNMIGLLSQAGSSITIQGAGEWIAA
LPETERNQMIIEEPEVLKNWDKQYGDRITELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS

Sequences:

>Translated_395_residues
MKKIPITVLSGFLGSGKTTLLHHILTNKNNLKVAVIVNDMGEVNIDASLIKKGGFSRTEEKLVEIQNGCICCTLREDLII
EVNRLVENGDIDYIVIESSGISEPIPVAQTFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFVDGESLLDRKQAINEN
DNREVIDLLIDQIEFANVIILNKIDLLEKEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQ
ELNSEHHTPETEEYGINSFVYRRKYPFHPERLMNWLGKWPVDVVRAKGFFWLASRNNMIGLLSQAGSSITIQGAGEWIAA
LPETERNQMIIEEPEVLKNWDKQYGDRITELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS
>Mature_395_residues
MKKIPITVLSGFLGSGKTTLLHHILTNKNNLKVAVIVNDMGEVNIDASLIKKGGFSRTEEKLVEIQNGCICCTLREDLII
EVNRLVENGDIDYIVIESSGISEPIPVAQTFTYTDDVLNIDLTKNCRLDTMVTVVDANRFWDDFVDGESLLDRKQAINEN
DNREVIDLLIDQIEFANVIILNKIDLLEKEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQ
ELNSEHHTPETEEYGINSFVYRRKYPFHPERLMNWLGKWPVDVVRAKGFFWLASRNNMIGLLSQAGSSITIQGAGEWIAA
LPETERNQMIIEEPEVLKNWDKQYGDRITELVFIGIDMNRSLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI126722884, Length=260, Percent_Identity=31.5384615384615, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI33469141, Length=260, Percent_Identity=31.5384615384615, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI146231952, Length=260, Percent_Identity=31.5384615384615, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI148727351, Length=260, Percent_Identity=31.1538461538462, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI223941779, Length=227, Percent_Identity=32.5991189427313, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI223941776, Length=249, Percent_Identity=30.5220883534137, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI119120938, Length=138, Percent_Identity=37.6811594202899, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI87082430, Length=369, Percent_Identity=27.9132791327913, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788499, Length=211, Percent_Identity=32.2274881516588, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=235, Percent_Identity=30.6382978723404, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 45055; Mature: 45055

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIPITVLSGFLGSGKTTLLHHILTNKNNLKVAVIVNDMGEVNIDASLIKKGGFSRTEE
CCCCCHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHCCCCCHHHH
KLVEIQNGCICCTLREDLIIEVNRLVENGDIDYIVIESSGISEPIPVAQTFTYTDDVLNI
HHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEE
DLTKNCRLDTMVTVVDANRFWDDFVDGESLLDRKQAINENDNREVIDLLIDQIEFANVII
EECCCCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEE
LNKIDLLEKEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQ
EECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
ELNSEHHTPETEEYGINSFVYRRKYPFHPERLMNWLGKWPVDVVRAKGFFWLASRNNMIG
HHCCCCCCCCCHHCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHCCCCEEEEECCCCEEE
LLSQAGSSITIQGAGEWIAALPETERNQMIIEEPEVLKNWDKQYGDRITELVFIGIDMNR
EHCCCCCEEEEEECCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHHEEEEEEEEECCCH
SLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS
HHHHHHHHHHHCCHHHHHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MKKIPITVLSGFLGSGKTTLLHHILTNKNNLKVAVIVNDMGEVNIDASLIKKGGFSRTEE
CCCCCHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHCCCCCHHHH
KLVEIQNGCICCTLREDLIIEVNRLVENGDIDYIVIESSGISEPIPVAQTFTYTDDVLNI
HHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEE
DLTKNCRLDTMVTVVDANRFWDDFVDGESLLDRKQAINENDNREVIDLLIDQIEFANVII
EECCCCCCCEEEEEEECHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEE
LNKIDLLEKEDVIELHQLLQKLNPNAKIIESSFSNVPLQEILNTNVFNYEEASQSAGWIQ
EECCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHHHCCCCCCCHHHHHHHHHHH
ELNSEHHTPETEEYGINSFVYRRKYPFHPERLMNWLGKWPVDVVRAKGFFWLASRNNMIG
HHCCCCCCCCCHHCCCCCEEEECCCCCCHHHHHHHHCCCCHHHHCCCCEEEEECCCCEEE
LLSQAGSSITIQGAGEWIAALPETERNQMIIEEPEVLKNWDKQYGDRITELVFIGIDMNR
EHCCCCCEEEEEECCCEEEECCCCCCCCEEECCCHHHHHHHHHHHHHEEEEEEEEECCCH
SLIEQSLDDCLLTEKEMTQNWNTFIDPIPAFTYTS
HHHHHHHHHHHCCHHHHHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]