Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 52143647

GI number: 52143647

Start: 1669810

End: 1671198

Strand: Direct

Name: fumC [H]

Synonym: BCZK1587

Alternate gene names: 52143647

Gene position: 1669810-1671198 (Clockwise)

Preceding gene: 52143648

Following gene: 52143644

Centisome position: 31.5

GC content: 37.72

Gene sequence:

>1389_bases
ATGGAGTACAGAATTGAAAGAGATACATTAGGAGAAATTAAAGTTCCAGCTGATAAATTATGGGCAGCACAAACGCAACG
TAGTAAAGAAAACTTCCCGATTGGAACAGAGCAAATGCCGCTTGAAATTGTAAAAGCATTTGCAATTTTAAAGAAGAGTG
CAGCACTTAGCAATCAAAAATTAGGAAAGTTATCAGAAGAAAAAGCAGAAGCAATTGTGACGGCTGCTGACGAAGTCATT
GCAGGGAAATGGAATGAACATTTTCCGCTTGTCGTATGGCAAACAGGTAGTGGTACACAATCAAACATGAATGTGAATGA
AGTAATTGCAAATCGTGGGAATCAAATTTTGAAAGAAAAGGGATCTGATGTATATATTCATCCGAATGATGATGTGAACA
TGTCTCAAAGTTCAAATGATACTTTCCCAACTGCGCTTCATGTAGCATGTGTACTCGCAGTAGAAAATCACGTATTACCA
GCTATTACGAAATTAAAAGAAACGTTAGCAGAAAAAGTAACTGCATTTGAACATATTATAAAAATTGGTCGTACACATTT
ACAAGATGCGACACCGTTAACTTTAGGGCAAGAAATTAGCGGATGGCACCGTATGCTTGAAAAAACAGAGCGTATGATTG
CAGAGAGCAATACATATATGAAAGAGCTTGCGATTGGTGGTACAGCAGTTGGAACAGGTATTAACGCTCATCCTAAATTT
GGTGAGATGGTATCAGAGGAAATTAGCCAATTTACAGGTAAACAATTTATTTCTGCACCAAATAAGTTCCATGCATTAAC
GAGCCATGATGAAGTTGTATATACTCACGGTGCATTAAAAGCATTAGCTGCGGATTTAATGAAAATCGCTAACGATGTAC
GTTGGCTTGCAAGTGGTCCACGTAGTGGTCTTGGAGAAATTATTATTCCAGCAAATGAACCGGGAAGCTCTATTATGCCA
GGTAAAGTAAATCCAACGCAAAGTGAAGCATTAACGATGGTTGTAGCGCAAGTGATGGGGAATGATGCAACAATCGGATT
TGCTGCGAGCCAAGGTAATTTTGAGTTGAACGTATTTAAACCTGTTATTGCTTATAACTTCTTACAATCAGCTCACTTAT
TAGCGGACGCAATTGTATCGTTTAATGATAATTGTGCAGTTGGTATTGAAGCAGATGAAGAAGTCATTAAAGAGAATGTG
AATCGTTCACTAATGCTTGTAACAGCATTAAACCCGCATATCGGATATGAAAATGCAGCGAAAATTGCAAAGCATGCTCA
TAAAGAAGGGTTAACTTTAAAAGAAGCAGCATTGCAATCTGGACTACTAACAGAAGAGCAATTTGATGAAATTGTCGATC
CGAAAAAAATGATTGCTCCGAAAGAGTAA

Upstream 100 bases:

>100_bases
ATATAAAATATCTGTATATAAGAGTGAGAATTCTTATCATTTAAGAGGAAGTCTGTTATTATAAGAGATGTAGGTATTTT
ATTTTCAAGGGGATGAAAAC

Downstream 100 bases:

>100_bases
TAAAAGAGCCGAGATTCTTTAGAATCTTGGCTCTTTCAATATATATCTTTTCTATTTGTATTACTGTAAGTACCAAAATA
AATTATTTGTTAGCAGGCAT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVTAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVYIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE

Sequences:

>Translated_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVTAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVYIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
>Mature_462_residues
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQKLGKLSEEKAEAIVTAADEVI
AGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEKGSDVYIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLP
AITKLKETLAEKVTAFEHIIKIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGPRSGLGEIIIPANEPGSSIMP
GKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFKPVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENV
NRSLMLVTALNPHIGYENAAKIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=462, Percent_Identity=59.5238095238095, Blast_Score=534, Evalue=1e-152,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=61.7067833698031, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=39.2624728850325, Blast_Score=331, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=58.351409978308, Blast_Score=536, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=57.0121951219512, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=58.1344902386117, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24640179, Length=464, Percent_Identity=56.8965517241379, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24640177, Length=464, Percent_Identity=56.8965517241379, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI78710009, Length=464, Percent_Identity=55.1724137931034, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24662684, Length=465, Percent_Identity=53.763440860215, Blast_Score=490, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24583245, Length=465, Percent_Identity=46.4516129032258, Blast_Score=425, Evalue=1e-119,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50346; Mature: 50346

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVTAADEVIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GSDVYIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVTAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure
MEYRIERDTLGEIKVPADKLWAAQTQRSKENFPIGTEQMPLEIVKAFAILKKSAALSNQK
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LGKLSEEKAEAIVTAADEVIAGKWNEHFPLVVWQTGSGTQSNMNVNEVIANRGNQILKEK
HCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHC
GSDVYIHPNDDVNMSQSSNDTFPTALHVACVLAVENHVLPAITKLKETLAEKVTAFEHII
CCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
KIGRTHLQDATPLTLGQEISGWHRMLEKTERMIAESNTYMKELAIGGTAVGTGINAHPKF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCCHH
GEMVSEEISQFTGKQFISAPNKFHALTSHDEVVYTHGALKALAADLMKIANDVRWLASGP
HHHHHHHHHHHHHHHHHCCCCHHEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCC
RSGLGEIIIPANEPGSSIMPGKVNPTQSEALTMVVAQVMGNDATIGFAASQGNFELNVFK
CCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHH
PVIAYNFLQSAHLLADAIVSFNDNCAVGIEADEEVIKENVNRSLMLVTALNPHIGYENAA
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEEEECCCCCCCHHHH
KIAKHAHKEGLTLKEAALQSGLLTEEQFDEIVDPKKMIAPKE
HHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]