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The map label for this gene is ilvB [H]

Identifier: 52143568

GI number: 52143568

Start: 1756437

End: 1758149

Strand: Direct

Name: ilvB [H]

Synonym: BCZK1666

Alternate gene names: 52143568

Gene position: 1756437-1758149 (Clockwise)

Preceding gene: 52143569

Following gene: 52143566

Centisome position: 33.13

GC content: 40.16

Gene sequence:

>1713_bases
ATGAAGCAATATACAACCTATGAGAAATTGCAGTGTAAAGAAGTGACAGGAACTGGACACGTTATTCAATGCTTAAAGAA
ATTAGGCGTAACGACTGTTTTCGGTTATCCGGGCGGAGCAATTTTACCAGTGTACGATGCGCTATATGAAAGTGGATTGA
AGCATATATTAACTCGTCATGAACAAGCTGCTATTCATGCGGCTGAAGGTTATGCAAGAGCTTCTGGAAAGGTCGGGGTA
GTATTTGCTACCTCTGGCCCAGGGGCGACGAATTTAGTTACAGGCTTAGCAGATGCTTATATGGATTCGATTCCTTTAGT
TGTCATTACAGGGCAAGTTGCAACACCACTCATCGGAAAAGACGGGTTTCAAGAAGCGGATGTTGTCGGAATTACAGTAC
CTGTTACGAAGCATAATTACCAAGTTCGTGATGTGAATCAGTTATCACGTATTGTACAAGAAGCTTTTTACATCGCCGAA
AGCGGGCGGCCAGGACCAGTATTAATTGATATTCCAAAAGATGTTCAAATTGAAAAGGTAACAAGTTTTTACAATGAAGT
AATTGAGATTCCAGGGTACAAAATAGAGGCCATGCCAGACAGTATGAAGCTTAAAGAGGTAGTTAAAGAAATTTCAAAAG
CGAAACGCCCACTTCTTTATATTGGGGGAGGTGTCATTCACTCAGGTGGATCTGATGAACTTATCAAATTTGCGAGGGAG
AATCGTATTCCAGTCGTGTCAACTTTAATGGGACTGGGTGCATATCCGCCGGGAGATCCATTATTTTTAGGAATGCTCGG
TATGCATGGAACGTACGCAGCAAACATGGCAGTAACAGAATGTGATTTACTGCTTGCGTTAGGTGTTCGTTTTGATGACC
GTGTAACAGGAAAACTGGAACTTTTTTCTCCGCATTCAAAAAAGGTACATATTGATATAGATCCTTCGGAGTTTCAAAAA
AATGTAGTGGTAAAGTATCCAGTTGTTGGAGATGTAAAAAAAGCGTTACACATGTTGTTACATATGCCAATTTGTACACA
GACAGATGAATGGCTTACGAAAACCGAGGAATGGAAAGCGGAATACCCCCTTTCCTATATTCAAAAAGAAAGTAAGTTAA
AACCACAGCATGTTATTAGTCTAGTAAGCGAATTAACGAATGGTGAAGCGATTGTTACGACAGAAGTAGGACAGCATCAA
ATGTGGGCTGCGCATTTTTATAAAGCGAAAAATCCACGGACTTTTCTAACATCTGGTGGGTTAGGAACGATGGGATTCGG
TTTCCCAGCGGCAATAGGTGCTCAGCTTGCTAAAGAAGAAGAACTTGTCATTTGTATCGCGGGCGATGCTTCTTTTCAAA
TGAACATTCAAGAACTGCAAACAATTGCTGAAAATAACATCCCTGTAAAAGTATTTATAATAAACAACAAATTTTTAGGG
ATGGTAAGGCAATGGCAAGAAATGTTTTATGAAAACCGATTGTCAGAGTCGAAAATTGGATCTCCAGATTTTGTGAAAGT
GGCAGAAGCTTATGGAGTGAAAGGATTAAGAGCGACAAATTCAACCGAGGCGAAACTAGTTATGATAGAAGCATTTGCTC
ATGAAGGTCCTGTCATAGTTGATTTTTGTGTAGAAGAAGGTGAAAACGTATTTCCGATGGTTCCGCCAAACAAAGGGAAT
AACGAAATGATTATGAAGAGGTGGGAAGAATGA

Upstream 100 bases:

>100_bases
CAATTGACTGAGGAATTTAAAAAGTTAACGAGAGAAAGAGGCGTACGTGTTCCAGGGCTGGCAGAAAGCTTACTGTAGGT
AGGGAGAGGGGTTAATTGAA

Downstream 100 bases:

>100_bases
GTCATACTTTTTCACTCGTTATTCATAACGAGCCAAGCGTCTTATTACGTATAAGTGGGATTTTTGCTCGGCGTGGTTAT
TATATTTCTTCTTTACATTT

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS; Vegetative protein 105; VEG105 [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MKQYTTYEKLQCKEVTGTGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRHEQAAIHAAEGYARASGKVGV
VFATSGPGATNLVTGLADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAE
SGRPGPVLIDIPKDVQIEKVTSFYNEVIEIPGYKIEAMPDSMKLKEVVKEISKAKRPLLYIGGGVIHSGGSDELIKFARE
NRIPVVSTLMGLGAYPPGDPLFLGMLGMHGTYAANMAVTECDLLLALGVRFDDRVTGKLELFSPHSKKVHIDIDPSEFQK
NVVVKYPVVGDVKKALHMLLHMPICTQTDEWLTKTEEWKAEYPLSYIQKESKLKPQHVISLVSELTNGEAIVTTEVGQHQ
MWAAHFYKAKNPRTFLTSGGLGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENNIPVKVFIINNKFLG
MVRQWQEMFYENRLSESKIGSPDFVKVAEAYGVKGLRATNSTEAKLVMIEAFAHEGPVIVDFCVEEGENVFPMVPPNKGN
NEMIMKRWEE

Sequences:

>Translated_570_residues
MKQYTTYEKLQCKEVTGTGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRHEQAAIHAAEGYARASGKVGV
VFATSGPGATNLVTGLADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAE
SGRPGPVLIDIPKDVQIEKVTSFYNEVIEIPGYKIEAMPDSMKLKEVVKEISKAKRPLLYIGGGVIHSGGSDELIKFARE
NRIPVVSTLMGLGAYPPGDPLFLGMLGMHGTYAANMAVTECDLLLALGVRFDDRVTGKLELFSPHSKKVHIDIDPSEFQK
NVVVKYPVVGDVKKALHMLLHMPICTQTDEWLTKTEEWKAEYPLSYIQKESKLKPQHVISLVSELTNGEAIVTTEVGQHQ
MWAAHFYKAKNPRTFLTSGGLGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENNIPVKVFIINNKFLG
MVRQWQEMFYENRLSESKIGSPDFVKVAEAYGVKGLRATNSTEAKLVMIEAFAHEGPVIVDFCVEEGENVFPMVPPNKGN
NEMIMKRWEE
>Mature_570_residues
MKQYTTYEKLQCKEVTGTGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRHEQAAIHAAEGYARASGKVGV
VFATSGPGATNLVTGLADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAE
SGRPGPVLIDIPKDVQIEKVTSFYNEVIEIPGYKIEAMPDSMKLKEVVKEISKAKRPLLYIGGGVIHSGGSDELIKFARE
NRIPVVSTLMGLGAYPPGDPLFLGMLGMHGTYAANMAVTECDLLLALGVRFDDRVTGKLELFSPHSKKVHIDIDPSEFQK
NVVVKYPVVGDVKKALHMLLHMPICTQTDEWLTKTEEWKAEYPLSYIQKESKLKPQHVISLVSELTNGEAIVTTEVGQHQ
MWAAHFYKAKNPRTFLTSGGLGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENNIPVKVFIINNKFLG
MVRQWQEMFYENRLSESKIGSPDFVKVAEAYGVKGLRATNSTEAKLVMIEAFAHEGPVIVDFCVEEGENVFPMVPPNKGN
NEMIMKRWEE

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=590, Percent_Identity=25.9322033898305, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI93004078, Length=497, Percent_Identity=25.9557344064386, Blast_Score=153, Evalue=5e-37,
Organism=Escherichia coli, GI87081685, Length=571, Percent_Identity=45.7092819614711, Blast_Score=520, Evalue=1e-148,
Organism=Escherichia coli, GI1790104, Length=565, Percent_Identity=42.6548672566372, Blast_Score=463, Evalue=1e-131,
Organism=Escherichia coli, GI1786717, Length=554, Percent_Identity=35.0180505415162, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI1787096, Length=548, Percent_Identity=26.6423357664234, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788716, Length=577, Percent_Identity=24.6100519930676, Blast_Score=140, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17531299, Length=539, Percent_Identity=26.7161410018553, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531301, Length=539, Percent_Identity=26.7161410018553, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17542570, Length=567, Percent_Identity=25.7495590828924, Blast_Score=149, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323755, Length=574, Percent_Identity=45.993031358885, Blast_Score=482, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6320816, Length=490, Percent_Identity=27.5510204081633, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6321524, Length=490, Percent_Identity=23.265306122449, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922626, Length=480, Percent_Identity=26.875, Blast_Score=162, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 62738; Mature: 62738

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQYTTYEKLQCKEVTGTGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRH
CCCCCCHHHEEEEEECCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
EQAAIHAAEGYARASGKVGVVFATSGPGATNLVTGLADAYMDSIPLVVITGQVATPLIGK
HHHHEEHHCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
DGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAESGRPGPVLIDIPKDVQIEKV
CCCCCCCEEEEEEEEECCCEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHH
TSFYNEVIEIPGYKIEAMPDSMKLKEVVKEISKAKRPLLYIGGGVIHSGGSDELIKFARE
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCEEEECCCCHHHHHHHHH
NRIPVVSTLMGLGAYPPGDPLFLGMLGMHGTYAANMAVTECDLLLALGVRFDDRVTGKLE
CCCCHHHHHHHCCCCCCCCCEEEEECCCCCCEECCEEHHHHHHHHHHCCCCCCCCCCEEE
LFSPHSKKVHIDIDPSEFQKNVVVKYPVVGDVKKALHMLLHMPICTQTDEWLTKTEEWKA
EECCCCCEEEEECCHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCC
EYPLSYIQKESKLKPQHVISLVSELTNGEAIVTTEVGQHQMWAAHFYKAKNPRTFLTSGG
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCC
LGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENNIPVKVFIINNKFLG
CCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEEHHHHHHHHCCCCCEEEEEECCHHHH
MVRQWQEMFYENRLSESKIGSPDFVKVAEAYGVKGLRATNSTEAKLVMIEAFAHEGPVIV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEECCCCCCEEEEEEEEECCCCCEEE
DFCVEEGENVFPMVPPNKGNNEMIMKRWEE
EEEECCCCCEECCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MKQYTTYEKLQCKEVTGTGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRH
CCCCCCHHHEEEEEECCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCC
EQAAIHAAEGYARASGKVGVVFATSGPGATNLVTGLADAYMDSIPLVVITGQVATPLIGK
HHHHEEHHCCHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCC
DGFQEADVVGITVPVTKHNYQVRDVNQLSRIVQEAFYIAESGRPGPVLIDIPKDVQIEKV
CCCCCCCEEEEEEEEECCCEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHH
TSFYNEVIEIPGYKIEAMPDSMKLKEVVKEISKAKRPLLYIGGGVIHSGGSDELIKFARE
HHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEECCEEEECCCCHHHHHHHHH
NRIPVVSTLMGLGAYPPGDPLFLGMLGMHGTYAANMAVTECDLLLALGVRFDDRVTGKLE
CCCCHHHHHHHCCCCCCCCCEEEEECCCCCCEECCEEHHHHHHHHHHCCCCCCCCCCEEE
LFSPHSKKVHIDIDPSEFQKNVVVKYPVVGDVKKALHMLLHMPICTQTDEWLTKTEEWKA
EECCCCCEEEEECCHHHHCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCC
EYPLSYIQKESKLKPQHVISLVSELTNGEAIVTTEVGQHQMWAAHFYKAKNPRTFLTSGG
CCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEECCC
LGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENNIPVKVFIINNKFLG
CCCCCCCCHHHHHHHHCCCCCEEEEEECCCCEEEEHHHHHHHHCCCCCEEEEEECCHHHH
MVRQWQEMFYENRLSESKIGSPDFVKVAEAYGVKGLRATNSTEAKLVMIEAFAHEGPVIV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEECCCCCCEEEEEEEEECCCCCEEE
DFCVEEGENVFPMVPPNKGNNEMIMKRWEE
EEEECCCCCEECCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 1577690; 9298659 [H]