Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 52143565

GI number: 52143565

Start: 1759444

End: 1761117

Strand: Direct

Name: ilvD [H]

Synonym: BCZK1669

Alternate gene names: 52143565

Gene position: 1759444-1761117 (Clockwise)

Preceding gene: 52143567

Following gene: 52143564

Centisome position: 33.19

GC content: 41.1

Gene sequence:

>1674_bases
ATGAGAAGTGACATGATTAAAAAAGGTTTTGATAAAGCGCCACACCGTAGTTTATTAAAAGCAACTGGTTTGAAAGATGA
AGATTTTGATAAACCGTTTATAGCTATCTGTAATTCTTTTATTGAAATTATTCCAGGTCATAAGCATTTAAATGAGTTTG
GGAAACTTGTTAAAGAAGCAGTGCGTGCAGCAGGTATGGTTCCATTTGAATTTAATACAATTGGAGTAGATGACGGTATT
GCGATGGGGCATATCGGTATGCGCTATTCGCTTCCGAGTCGAGAAATCATTGCAGATTCAGTAGAAACGGTTGTAAATGC
ACACTGGTTTGATGGCATGATTTGTATTCCAAACTGTGACAAAATCACACCTGGTATGATGATGGCTGCACTACGTATTA
ATATTCCGACTGTGTTTGTTTCGGGCGGCCCGATGGCAGCAGGAAAAACATCTAAAGGAGAAGTTGTTGATCTGAGTTCC
GTTTTTGAAGGAGTAGGAGCTTATCAATCTGGGAAAATTTCAGAAGAAGAATTAAAAGATATTGAAGATCATGGCTGTCC
ATCTTGTGGTTCTTGTTCCGGTATGTTTACAGCGAACTCTATGAACTGTTTATGTGAAGTGTTAGGTTTAGCTCTTCCTG
GTAACGGAAGTATTTTGGCTATTGATCCGAGACGTGAGGAGTTAATTAAAGAAGCAGCAGAAAAATTAAAGATTTTAATT
GAAAGAGATATTAAACCACGAGACATTGTAACGGAAGAAGCAATTGATGATGCGTTCGCGCTTGATATGGCGATGGGCGG
TTCAACAAATACAGTGTTACATACATTAGCACTCGCACATGAGGCAGGACTAGATTATGATATGAGCCGTATTGATGCCG
TTTCAAGACGTGTACCACATTTATGTAAAGTAAGCCCTGCTTCCAATTGGCATATGGAAGACATTGATCGTGCAGGCGGG
ATTAGTGCCATTTTGAAAGAGATGAGCCGAAAAGAAGGGGTACTTCATTTAGACCGTATTACTGCTACGGGGCAAACATT
AAGAGGAAATATTGCTCATGCAGAGATTAAAGATAAGGAAGTGATTCATTCTCTTGAAAATCCTCATAGTGAAGAAGGTG
GATTACGTATATTAAAAGGAAACCTTGCGAAAGACGGAGCAGTTATTAAAAGCGGGGCAACTGAAGTGAAACGATTTGAA
GGACCTTGTGTTATTTTTAATTCACAAGATGAGGCGCTTGCCGGCATTATGCTTGGGAAGGTTAAGAAAGGAGACGTAGT
TGTTATTCGTTATGAAGGACCAAGAGGCGGTCCTGGTATGCCGGAAATGTTAGCACCAACGTCAGCGATTGCTGGCATGG
GATTAGGTGCAGATGTTGCGTTATTAACCGATGGTCGTTTCTCTGGTGCTTCACGTGGTATTTCAGTAGGTCATATTTCG
CCAGAAGCAGCTGCGGGCGGGACCATCGCACTTCTTGAACAAGGGGATATCGTTTGTATCGATGTTGAGGAAAGGTTGTT
AGAAGTAAGAGTGAGTGACGAAGAATTAGATAAGCGTAAAAAAGAATGGAAACGACCAGAACCGAAAGTGAAAACGGGCT
GGCTTGGGCGTTATGCACAAATGGTAACATCGGCGAATACAGGTGCAGTCTTAAAAGTCCCGAATTTTGATTGA

Upstream 100 bases:

>100_bases
GCTTCGTGAAATGATGAGCTGGATTCATGCACCGAAAGAATTAGTAAAGAAATAGAGTAAGAGATTATAAGTAAAAATAC
GTAAGAGGGGATTTGACAAG

Downstream 100 bases:

>100_bases
GCCAATTAAAAAGAGATAAGGATGATATGAAATGGTGCAGAAGGTAAAGGAGAGAGTGAAAATTGAAGATATCTTAATGG
CCCATAATTGCATGAAAGAT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKEAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAHEAGLDYDMSRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRGNIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKVPNFD

Sequences:

>Translated_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKEAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAHEAGLDYDMSRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRGNIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKVPNFD
>Mature_557_residues
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEAVRAAGMVPFEFNTIGVDDGI
AMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCDKITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSS
VFEGVGAYQSGKISEEELKDIEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKEAAEKLKILI
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAHEAGLDYDMSRIDAVSRRVPHLCKVSPASNWHMEDIDRAGG
ISAILKEMSRKEGVLHLDRITATGQTLRGNIAHAEIKDKEVIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFE
GPCVIFNSQDEALAGIMLGKVKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQMVTSANTGAVLKVPNFD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=47.8547854785479, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1788157, Length=540, Percent_Identity=30.9259259259259, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI2367371, Length=526, Percent_Identity=31.7490494296578, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1786464, Length=489, Percent_Identity=31.0838445807771, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=545, Percent_Identity=42.3853211009174, Blast_Score=427, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 59904; Mature: 59904

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEEECCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKEAAEKLKILI
HHHCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAHEAGLDYDMSRIDAVSRRVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRGNIAHAEIKDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCHHCCCEEECCCCHHH
VIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCHHHHHCCCCEEEECCCCHHHHHHHHCC
VKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQ
CCCCCCCEEEEEECCCEEEEEHHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKVPNFD
HHHCCCCCCEEECCCCC
>Mature Secondary Structure
MRSDMIKKGFDKAPHRSLLKATGLKDEDFDKPFIAICNSFIEIIPGHKHLNEFGKLVKEA
CCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VRAAGMVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIADSVETVVNAHWFDGMICIPNCD
HHHCCCCCEEEEEECCCCCCEECCCCEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCC
KITPGMMMAALRINIPTVFVSGGPMAAGKTSKGEVVDLSSVFEGVGAYQSGKISEEELKD
CCCHHHHHHHEEEECCEEEECCCCCCCCCCCCCCEEEHHHHHHHHCCCCCCCCCHHHHHH
IEDHGCPSCGSCSGMFTANSMNCLCEVLGLALPGNGSILAIDPRREELIKEAAEKLKILI
HHHCCCCCCCCCCCCEECCHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHHHHHH
ERDIKPRDIVTEEAIDDAFALDMAMGGSTNTVLHTLALAHEAGLDYDMSRIDAVSRRVPH
HCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
LCKVSPASNWHMEDIDRAGGISAILKEMSRKEGVLHLDRITATGQTLRGNIAHAEIKDKE
CEECCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEECCCHHCCCEEECCCCHHH
VIHSLENPHSEEGGLRILKGNLAKDGAVIKSGATEVKRFEGPCVIFNSQDEALAGIMLGK
HHHHHCCCCCCCCCEEEEECCCCCCCCEEECCCHHHHHCCCCEEEECCCCHHHHHHHHCC
VKKGDVVVIRYEGPRGGPGMPEMLAPTSAIAGMGLGADVALLTDGRFSGASRGISVGHIS
CCCCCEEEEEECCCCCCCCCCHHHCCHHHHHCCCCCCCEEEEECCCCCCCCCCEEEECCC
PEAAAGGTIALLEQGDIVCIDVEERLLEVRVSDEELDKRKKEWKRPEPKVKTGWLGRYAQ
CCCCCCCEEEEEECCCEEEEEHHHHEEEEECCHHHHHHHHHHHCCCCCCCCCCHHHHHHH
MVTSANTGAVLKVPNFD
HHHCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA