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The map label for this gene is pyn [H]

Identifier: 52143529

GI number: 52143529

Start: 1804493

End: 1805794

Strand: Direct

Name: pyn [H]

Synonym: BCZK1705

Alternate gene names: 52143529

Gene position: 1804493-1805794 (Clockwise)

Preceding gene: 52143531

Following gene: 52143527

Centisome position: 34.04

GC content: 37.25

Gene sequence:

>1302_bases
ATGAGAATGGTAGATATTATTGCGAAAAAACGTGACGGCAAAGAATTAACAACTGAAGAAATCAAATTCTTTATTAATGG
TTATACAGATGGAAGTATACCTGATTATCAAGTAAGTGCACTTGCAATGGCAATCTTCTTTAAAGATATGACAGATCGCG
AACGTGCAGATTTAACGATGGCAATGGTGGAGTCTGGAGAAACAATCGACTTATCTGCAATTGAAGGAATTAAAGTAGAC
AAACATTCAACTGGTGGTGTTGGTGATACAACAACATTAGTATTAGGGCCATTAGTAGCTGCTTTAGATGTACCAGTAGC
AAAAATGTCTGGTCGTGGTTTAGGACATACGGGCGGAACAATTGATAAATTAGAAGCAGTAGAAGGATTCCACGTTGAAA
TTACGAAAGAGCAGTTCATTGATATTGTAAACCGTGACAAAGTAGCTGTTATCGGACAAACAGGAAACTTAACACCTGCA
GATAAAAAGATTTATGCATTACGCGATGTAACAGGAACTGTTAACTCAATTCCTCTAATTGCAAGTTCAATTATGAGTAA
AAAAATTGCAGCTGGAGCTGACGCAATCGTACTTGATGTAAAAACAGGTGCTGGCGCGTTTATGAAAACAGAAGAAGATG
CAAAAGAATTAGCACATGCAATGGTACGTATCGGAAATAATGTAGGACGTCAAACTATGGCTGTTATTTCAGATATGTCA
CAACCACTTGGTTTTGCAATTGGTAACGCTCTAGAAGTGAAAGAAGCAATTGATACGTTAAAAGGTGAAGGTCCAGAAGA
TTTAACAGAATTAGTACTCGTATTAGGAAGTCAGATGGTTGTACTTGCGAAAAAGGCAAATACATTAGAAGAAGCGCGTG
AAATGTTAATTGAAGTGATGAAGAATGGAAAAGCGACTGAGAAGTTTAAAGAGTTCTTAAGCAATCAAGGCGGAGATAGC
TCGATTGTAGACAATCCAGAAAAAATGCCACAAGCGAAATATGTAATTGATGTACCTGCTAAAACTTCAGGTGTTATTTC
TAACATTGTTGCTGATGAAATCGGTATCGCAGCTATGCTACTTGGTGCTGGTCGTGCAACAAAAGAAGATGAAATCGATT
TAGCAGTAGGATTAATGTTACGTAAAAAAGTGGGCGATGCAGTAAAAGAAGGCGAGCCATTCGTAACGATTTATGCAAAT
CGCGAAAATGTAGAAGATGTAAAAGCTAAAATTTATGAGAACATTTCTATCGCTGAAACAGCAGTGGCTCCTAAATTAGT
TCATACAGTTATTACTGACTAA

Upstream 100 bases:

>100_bases
ATTACTTTTCGGTGCAACATTAGTAAGCTTCTTATCAGCAACAATCGTAGGCTTATTATTTTAATAGATTCATATCATAT
AAAAAGGAATGGTGATTGTA

Downstream 100 bases:

>100_bases
TCATAATTACACTTACTTTGAGGGGGAAATAATATGGATAAGAAAAAATATATTGAAGAAGCAAATAAGATGTTGTCGAA
AGCATATATTCCGTATTCAA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLSNQGGDS
SIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYAN
RENVEDVKAKIYENISIAETAVAPKLVHTVITD

Sequences:

>Translated_433_residues
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLSNQGGDS
SIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYAN
RENVEDVKAKIYENISIAETAVAPKLVHTVITD
>Mature_433_residues
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTMAMVESGETIDLSAIEGIKVD
KHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGTIDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPA
DKKIYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVMKNGKATEKFKEFLSNQGGDS
SIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAMLLGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYAN
RENVEDVKAKIYENISIAETAVAPKLVHTVITD

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI4503445, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=5e-72,
Organism=Homo sapiens, GI166158922, Length=423, Percent_Identity=35.4609929078014, Blast_Score=268, Evalue=5e-72,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=46.7821782178218, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46295; Mature: 46295

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTM
CCHHHHHHCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEH
AMVESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGT
EECCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNSIPLI
HHHHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
KNGKATEKFKEFLSNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAML
HCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENISIAET
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHH
AVAPKLVHTVITD
HHHHHHHHHHHCC
>Mature Secondary Structure
MRMVDIIAKKRDGKELTTEEIKFFINGYTDGSIPDYQVSALAMAIFFKDMTDRERADLTM
CCHHHHHHCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEH
AMVESGETIDLSAIEGIKVDKHSTGGVGDTTTLVLGPLVAALDVPVAKMSGRGLGHTGGT
EECCCCCEEEEEECCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLEAVEGFHVEITKEQFIDIVNRDKVAVIGQTGNLTPADKKIYALRDVTGTVNSIPLI
HHHHHHCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHH
ASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAKELAHAMVRIGNNVGRQTMAVISDMS
HHHHHHHHHHCCCCEEEEEECCCCCCCEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
QPLGFAIGNALEVKEAIDTLKGEGPEDLTELVLVLGSQMVVLAKKANTLEEAREMLIEVM
CCHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
KNGKATEKFKEFLSNQGGDSSIVDNPEKMPQAKYVIDVPAKTSGVISNIVADEIGIAAML
HCCCHHHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
LGAGRATKEDEIDLAVGLMLRKKVGDAVKEGEPFVTIYANRENVEDVKAKIYENISIAET
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCHHHH
AVAPKLVHTVITD
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]