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The map label for this gene is ffp [H]

Identifier: 52143510

GI number: 52143510

Start: 1840106

End: 1840774

Strand: Direct

Name: ffp [H]

Synonym: BCZK1719

Alternate gene names: 52143510

Gene position: 1840106-1840774 (Clockwise)

Preceding gene: 52143509

Following gene: 52143511

Centisome position: 34.71

GC content: 29.0

Gene sequence:

>669_bases
GTGTTGGTTTTGATAGAAGTGTTTCTAATTAATATCTCTAAAATATCGGAAAATAAGATGAAAAAAATGGAAAGTATTAT
AAGTAAAGATATTTTAAACGAAATACAGTTAATCAAGGTAAAAGAAGAAAGGAGAAGAAGAATTACGAGTGCGTATTTTT
TACAAGATTTATTAAGTAAAAAGCTTGGAGTCCCACCAGCAAATATTGAAATTATGAAAAATGAATATGGAAAAAAGAGA
TGTTCAAATGATGTTAATCTCCATTTCAATATATCACATTCAGGAGACTGGGTGGCGGTGGGCTTTAGTCGTTTTGAAAT
CGGAATCGATATCGAAGAAATGCTTGAATTTGATTTTAAGGAGGTGATTCCATTTTTTGTGGAAGAAGAACAAGTGTATT
TAAATGGTTTGAACAAACAAAAAAAGATGTTTCAATTCTATAGAATGTGGACAGCGAAAGAAAGTTATATGAAATATACA
GGACTAGGATTCAATTTAGATTTGAATTCATTTTCTATTCCGTTTCAAAATTATGGTGAAATAAAATTGTCGAATCCACA
TTTTCGAGATGGACCAAAGGTTTCTTCATTTCTATTTGATGACAAATACTACATGAGTATTTGTTCTGAAAAAATAGAAA
ATATAACTTTGGACTACAAACATTATTAA

Upstream 100 bases:

>100_bases
ACAAGGTACATTTGATGAATTAATTCAAAATCATGATTCTTTTTACTATTTCCATTCAGTAAGAGAAGTTGTGTAACGAA
ACTTAGTAATTTCGTAGGAG

Downstream 100 bases:

>100_bases
TCAAAAAATGGGAATTTAATTCTTTTTCCTATACACCTTTTATAAGAAGAACAATTTATCTAGATAATAGAATGAAATGA
ACCAGATATTTATTAAATAT

Product: 4'-phosphopantetheinyl transferase

Products: adenosine 3',5'-bisphosphate [C]

Alternate protein names: Lipopeptide antibiotics iturin A and surfactin biosynthesis protein [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MLVLIEVFLINISKISENKMKKMESIISKDILNEIQLIKVKEERRRRITSAYFLQDLLSKKLGVPPANIEIMKNEYGKKR
CSNDVNLHFNISHSGDWVAVGFSRFEIGIDIEEMLEFDFKEVIPFFVEEEQVYLNGLNKQKKMFQFYRMWTAKESYMKYT
GLGFNLDLNSFSIPFQNYGEIKLSNPHFRDGPKVSSFLFDDKYYMSICSEKIENITLDYKHY

Sequences:

>Translated_222_residues
MLVLIEVFLINISKISENKMKKMESIISKDILNEIQLIKVKEERRRRITSAYFLQDLLSKKLGVPPANIEIMKNEYGKKR
CSNDVNLHFNISHSGDWVAVGFSRFEIGIDIEEMLEFDFKEVIPFFVEEEQVYLNGLNKQKKMFQFYRMWTAKESYMKYT
GLGFNLDLNSFSIPFQNYGEIKLSNPHFRDGPKVSSFLFDDKYYMSICSEKIENITLDYKHY
>Mature_222_residues
MLVLIEVFLINISKISENKMKKMESIISKDILNEIQLIKVKEERRRRITSAYFLQDLLSKKLGVPPANIEIMKNEYGKKR
CSNDVNLHFNISHSGDWVAVGFSRFEIGIDIEEMLEFDFKEVIPFFVEEEQVYLNGLNKQKKMFQFYRMWTAKESYMKYT
GLGFNLDLNSFSIPFQNYGEIKLSNPHFRDGPKVSSFLFDDKYYMSICSEKIENITLDYKHY

Specific function: May activate the peptidyl carrier protein (PCP) domains of surfactin synthetase SRF1/2/3 and iturin A synthetase, by transferring the 4'-phosphopantetheinyl moiety of coenzyme A (CoA) to a serine residue. Required for the coproduction of the lipopeptide a

COG id: COG2091

COG function: function code H; Phosphopantetheinyl transferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the P-Pant transferase superfamily. Gsp/sfp/hetI/acpT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008278
- InterPro:   IPR004568 [H]

Pfam domain/function: PF01648 ACPS [H]

EC number: NA

Molecular weight: Translated: 26289; Mature: 26289

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLIEVFLINISKISENKMKKMESIISKDILNEIQLIKVKEERRRRITSAYFLQDLLSK
CEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHH
KLGVPPANIEIMKNEYGKKRCSNDVNLHFNISHSGDWVAVGFSRFEIGIDIEEMLEFDFK
HHCCCCCCEEEECCHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEECCCHHHHHCCCHH
EVIPFFVEEEQVYLNGLNKQKKMFQFYRMWTAKESYMKYTGLGFNLDLNSFSIPFQNYGE
HHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEECCCCCCCE
IKLSNPHFRDGPKVSSFLFDDKYYMSICSEKIENITLDYKHY
EEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCEEEEECCC
>Mature Secondary Structure
MLVLIEVFLINISKISENKMKKMESIISKDILNEIQLIKVKEERRRRITSAYFLQDLLSK
CEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHH
KLGVPPANIEIMKNEYGKKRCSNDVNLHFNISHSGDWVAVGFSRFEIGIDIEEMLEFDFK
HHCCCCCCEEEECCHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEECCCHHHHHCCCHH
EVIPFFVEEEQVYLNGLNKQKKMFQFYRMWTAKESYMKYTGLGFNLDLNSFSIPFQNYGE
HHHHHHHCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEECCCCCCCE
IKLSNPHFRDGPKVSSFLFDDKYYMSICSEKIENITLDYKHY
EEECCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; apo-[acyl carrier protein] [C]

Specific reaction: Coenzyme A + apo-[acyl carrier protein] = adenosine 3',5'-bisphosphate + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8939709 [H]