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The map label for this gene is mdmC [H]

Identifier: 52143459

GI number: 52143459

Start: 1901717

End: 1902388

Strand: Direct

Name: mdmC [H]

Synonym: BCZK1776

Alternate gene names: 52143459

Gene position: 1901717-1902388 (Clockwise)

Preceding gene: 52143458

Following gene: 52143457

Centisome position: 35.88

GC content: 38.1

Gene sequence:

>672_bases
ATGAGTACGATTGAGAAATGGACGGCTGTTGATCAATATGTGAGTGACATATTAATACCGAAAGATTCTACATTAGAAGA
AGTACTTCAAACTAATGCTACAGCTAATATACCAGCACATGATGTATCGCCAACGCAAGGGATGTTTTTACAACTATTAG
TACAAATTCAAGGGGCTCGTAACATTTTAGAAATTGGTACTCTAGGTGGGTATAGCACGATATGGCTTGCAAGAGGATTG
TCATCTGAAGGACGAGTTGTTACATTGGAAGCGAGTGAAAAACATGCAGAAATTGCACGTAATAATATTGAGCGTGCTAA
TTTGACTGATAAAATTGAAATACGATTGGGATTTGCTTTAGATTCTTTAAAGCAAATCGAAAATGAGAAGTATGAACCCT
TTGACTTTATTTTTATAGACGCTGATAAACAAAATAACCCCGCTTATTTTGAATGGGCACTGAAACTATCACGTCCGGGG
ACTGTAATTATTGGAGATAACGTAGTACGTGAAGGAGAAGTTATTGACAATACGAGTAATGACCCTCGCGTACAAGGGAT
ACGTCGTTTCTATGAATTAATAGCTACAGAGCCACGTGTAAGTGCTACTGCGCTTCAAACGGTGGGTAGTAAAGGGTACG
ATGGATTTATAATGGCGGTCGTAAAAGAATAA

Upstream 100 bases:

>100_bases
GATGTCCCTTCTTTATTTTTTGTATATGAGACAGAATTTTCGGTATAATTGAAAGCGAATAGTAGAAATGCATTGGAAAA
TTGAAGGGGATGGTATTTAC

Downstream 100 bases:

>100_bases
CGAAAGGAGATAAATAGAATGAAAAAGATGTTTGAAAAATTATAACATGTATCGTGTATAACGAGATTAGCTCGTGGACC
TCCAGTATACATAGCACTAT

Product: O-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANIPAHDVSPTQGMFLQLLVQIQGARNILEIGTLGGYSTIWLARGL
SSEGRVVTLEASEKHAEIARNNIERANLTDKIEIRLGFALDSLKQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPG
TVIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE

Sequences:

>Translated_223_residues
MSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANIPAHDVSPTQGMFLQLLVQIQGARNILEIGTLGGYSTIWLARGL
SSEGRVVTLEASEKHAEIARNNIERANLTDKIEIRLGFALDSLKQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPG
TVIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE
>Mature_222_residues
STIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANIPAHDVSPTQGMFLQLLVQIQGARNILEIGTLGGYSTIWLARGLS
SEGRVVTLEASEKHAEIARNNIERANLTDKIEIRLGFALDSLKQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGT
VIIGDNVVREGEVIDNTSNDPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=205, Percent_Identity=30.2439024390244, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25148771, Length=200, Percent_Identity=30, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17565612, Length=208, Percent_Identity=29.8076923076923, Blast_Score=73, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 24830; Mature: 24699

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANIPAHDVSPTQGMFLQLLVQIQGAR
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
NILEIGTLGGYSTIWLARGLSSEGRVVTLEASEKHAEIARNNIERANLTDKIEIRLGFAL
CEEEECCCCCHHHHHEECCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEEEEEEHHH
DSLKQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGTVIIGDNVVREGEVIDNTSN
HHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCEEEECCCEEECCCEECCCCC
DPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE
CHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure 
STIEKWTAVDQYVSDILIPKDSTLEEVLQTNATANIPAHDVSPTQGMFLQLLVQIQGAR
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
NILEIGTLGGYSTIWLARGLSSEGRVVTLEASEKHAEIARNNIERANLTDKIEIRLGFAL
CEEEECCCCCHHHHHEECCCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEEEEEEEEHHH
DSLKQIENEKYEPFDFIFIDADKQNNPAYFEWALKLSRPGTVIIGDNVVREGEVIDNTSN
HHHHHHHCCCCCCEEEEEEECCCCCCCEEEEEEEEECCCCEEEECCCEEECCCEECCCCC
DPRVQGIRRFYELIATEPRVSATALQTVGSKGYDGFIMAVVKE
CHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]