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The map label for this gene is sirC [H]

Identifier: 52143293

GI number: 52143293

Start: 2058117

End: 2058590

Strand: Reverse

Name: sirC [H]

Synonym: BCZK1945

Alternate gene names: 52143293

Gene position: 2058590-2058117 (Counterclockwise)

Preceding gene: 52143290

Following gene: 52143301

Centisome position: 38.83

GC content: 35.02

Gene sequence:

>474_bases
ATGTATAACATGTACCCCCTTATGTTTAATCTGCAAAATAAAGTGGTCGTTATCATTGGTGGAGGTAAAATTGCATATCG
AAAAGCGTCTGGATTAAAAAATACAGGCGCTTTCGTCACCGTTATTAGCCCCGAGATTTGCGAGGAAATGAAAGAACTTC
CTTATATTACTTGGAAGCAAAAAACTTTTAGTAATGATGATATTAAAGATGCTCATCTTATTTATGCAGCTACAAATCAA
CATGCTGTAAATATGATGGTTAAACAGGCTGCCCACAATTTCCAGTGGGTTAACGTTGTAAGTGATGGTACAGAATCATC
TTTTCACACACCGGGCGTTATAAGAAATGATGAATATGTTGTCACTATTTCAACTTCTGGTAAAGATCCATCATTTACGA
AGCGTTTGAAGCAAGAACTAACATCTATATTGCCTAAACTTATAAAAAAGATTGCTCGTACACATAAATTGTAA

Upstream 100 bases:

>100_bases
TTGTATACAAAAAAATACGATCACGTGACGACTTGTAATTGCCTACAGTTTGATACATATATGAAATTAACTTTGTTAGA
ACGAATGGAGGAATGCATAT

Downstream 100 bases:

>100_bases
TCTATTTCTTAGTTAAAATAGTAATTACCTTTGGACAAACGTTTTTTAGGGGACGTTTGTTCTTTTTATTGTAGTTCCGT
TCTTTTATTCCACAAGCAAT

Product: precorrin-2 dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MYNMYPLMFNLQNKVVVIIGGGKIAYRKASGLKNTGAFVTVISPEICEEMKELPYITWKQKTFSNDDIKDAHLIYAATNQ
HAVNMMVKQAAHNFQWVNVVSDGTESSFHTPGVIRNDEYVVTISTSGKDPSFTKRLKQELTSILPKLIKKIARTHKL

Sequences:

>Translated_157_residues
MYNMYPLMFNLQNKVVVIIGGGKIAYRKASGLKNTGAFVTVISPEICEEMKELPYITWKQKTFSNDDIKDAHLIYAATNQ
HAVNMMVKQAAHNFQWVNVVSDGTESSFHTPGVIRNDEYVVTISTSGKDPSFTKRLKQELTSILPKLIKKIARTHKL
>Mature_157_residues
MYNMYPLMFNLQNKVVVIIGGGKIAYRKASGLKNTGAFVTVISPEICEEMKELPYITWKQKTFSNDDIKDAHLIYAATNQ
HAVNMMVKQAAHNFQWVNVVSDGTESSFHTPGVIRNDEYVVTISTSGKDPSFTKRLKQELTSILPKLIKKIARTHKL

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis (Probable) [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789768, Length=152, Percent_Identity=28.2894736842105, Blast_Score=70, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 17734; Mature: 17734

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNMYPLMFNLQNKVVVIIGGGKIAYRKASGLKNTGAFVTVISPEICEEMKELPYITWKQ
CCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHCCEEEEEC
KTFSNDDIKDAHLIYAATNQHAVNMMVKQAAHNFQWVNVVSDGTESSFHTPGVIRNDEYV
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCEE
VTISTSGKDPSFTKRLKQELTSILPKLIKKIARTHKL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYNMYPLMFNLQNKVVVIIGGGKIAYRKASGLKNTGAFVTVISPEICEEMKELPYITWKQ
CCCCEEEEEECCCCEEEEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHCCEEEEEC
KTFSNDDIKDAHLIYAATNQHAVNMMVKQAAHNFQWVNVVSDGTESSFHTPGVIRNDEYV
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCEE
VTISTSGKDPSFTKRLKQELTSILPKLIKKIARTHKL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 10217486 [H]