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The map label for this gene is ampC [C]

Identifier: 52143186

GI number: 52143186

Start: 2170955

End: 2172112

Strand: Direct

Name: ampC [C]

Synonym: BCZK2051

Alternate gene names: 52143186

Gene position: 2170955-2172112 (Clockwise)

Preceding gene: 52143189

Following gene: 52143185

Centisome position: 40.95

GC content: 39.9

Gene sequence:

>1158_bases
ATGAAAACACACAGTAAAATTACATGTGCAAGTCTAGCACTTTTAATAGCTGGAAGTTCCCTGTTATACATAACACCAGC
CTCAATTGTAAAAGCAGAACCTACGCAAAATGTATCTAGTTCGTTACAAACAAGTATGCAAAGCGATCGTACTTCCGTTA
AGAAAGCAATACGGGATGCACTACAACTTGGGTACCCGGGAATACTCGCTAACATTTCTAAGGGTGGTAAAACTTGGAGT
TATACCGCTGGGTTAGCAGATGTGAGAACCAAGAAACCAATGAAAGCAGATTTTCGCTTTCGTATTGGCAGTGTGACGAA
AACGTTCATTGCAACAGTTCTACTTCAATTATCTGGAGAGAATCGTTTGAATCTAGATGACTCCATTGAAAAATGGTTGC
CTGGTGTCATTCAAGGAAACGGATATGATGGTAACCAGATTACGATCCGGCAAATATTGAATCATACAAGTGGGATTGCT
GATTATATAAACTCAAAAGACTTTGATATTATGGATATAAAAAAATCGTATACGGCTGAAGAATTTGTAAAGATGGGGAT
TTCTCTTCCCCCAGACTTTGCTCCAGGGAAGGGTTGGTCTTATTCAAATACAGGATACGTAATACTAGGAATCCTTATTG
AAAAGGTAACAGGAAACAGTTATGCGGAAGAGGTTGAAAATCGGATTATTGAACCGCTTGATTTATCAAATACATTCCTA
CCTGGCAATTCAAGCGTGATTCCAGGCACCAAGCATGCCCGTGGCTATTTGCAACGAGACGGAGCAAGTGAGCTAAAAGA
CGTTACTTATATTAACCCAGGTAGCTCGGATGGAGATATGATTTCTACTGCTGACGACTTAAACAAATTCTTCTCTTACT
TACTAGGTGGCAAATTACTGAAGGAACAGCAACTAAAACAAATGCTTACTACAGTTCCTACAGAAAGAGAGGGAACTGGA
TATGGTCTTGGAATACTTGAAATTAAGCTTCCAAATGGTGTCTCGGTATGGGGACACAGGGGGGGCGTTCCAGGGTTTTC
CACTTTTGTTGGTGGAACACTTGGAGGCAAGCATACATTGGCCGTCAATTTGAACAGCTTTAACTTTAGTAATCCTGATC
CTTTTAAAAGTATTTTACTTGCTGAATTTAGGAAGTAG

Upstream 100 bases:

>100_bases
GTGTTGACTTTTATCATTGGGAGAGTTGATAGCTGTGTGGTTCGTATATGACATACCTATCAACCATCAATACAATTTAA
ATAGAAGAGAGGAATTCTTT

Downstream 100 bases:

>100_bases
GCAAAAAGGAAAAAAGGATAAGTTTTGTCATAGTTTTATAGTTTAAAATATACCATTTTGGTGCAAAAAACAACTTGCTC
TAAAAAATTTAATACTCGTA

Product: D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein)

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKTHSKITCASLALLIAGSSLLYITPASIVKAEPTQNVSSSLQTSMQSDRTSVKKAIRDALQLGYPGILANISKGGKTWS
YTAGLADVRTKKPMKADFRFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQGNGYDGNQITIRQILNHTSGIA
DYINSKDFDIMDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVENRIIEPLDLSNTFL
PGNSSVIPGTKHARGYLQRDGASELKDVTYINPGSSDGDMISTADDLNKFFSYLLGGKLLKEQQLKQMLTTVPTEREGTG
YGLGILEIKLPNGVSVWGHRGGVPGFSTFVGGTLGGKHTLAVNLNSFNFSNPDPFKSILLAEFRK

Sequences:

>Translated_385_residues
MKTHSKITCASLALLIAGSSLLYITPASIVKAEPTQNVSSSLQTSMQSDRTSVKKAIRDALQLGYPGILANISKGGKTWS
YTAGLADVRTKKPMKADFRFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQGNGYDGNQITIRQILNHTSGIA
DYINSKDFDIMDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVENRIIEPLDLSNTFL
PGNSSVIPGTKHARGYLQRDGASELKDVTYINPGSSDGDMISTADDLNKFFSYLLGGKLLKEQQLKQMLTTVPTEREGTG
YGLGILEIKLPNGVSVWGHRGGVPGFSTFVGGTLGGKHTLAVNLNSFNFSNPDPFKSILLAEFRK
>Mature_385_residues
MKTHSKITCASLALLIAGSSLLYITPASIVKAEPTQNVSSSLQTSMQSDRTSVKKAIRDALQLGYPGILANISKGGKTWS
YTAGLADVRTKKPMKADFRFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQGNGYDGNQITIRQILNHTSGIA
DYINSKDFDIMDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVENRIIEPLDLSNTFL
PGNSSVIPGTKHARGYLQRDGASELKDVTYINPGSSDGDMISTADDLNKFFSYLLGGKLLKEQQLKQMLTTVPTEREGTG
YGLGILEIKLPNGVSVWGHRGGVPGFSTFVGGTLGGKHTLAVNLNSFNFSNPDPFKSILLAEFRK

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=272, Percent_Identity=23.8970588235294, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082101, Length=238, Percent_Identity=25.6302521008403, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI115533026, Length=339, Percent_Identity=26.8436578171091, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17550934, Length=314, Percent_Identity=25.796178343949, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565630, Length=243, Percent_Identity=27.1604938271605, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 41802; Mature: 41802

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTHSKITCASLALLIAGSSLLYITPASIVKAEPTQNVSSSLQTSMQSDRTSVKKAIRDA
CCCCCHHHHHHHHHHHHCCCEEEECCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQLGYPGILANISKGGKTWSYTAGLADVRTKKPMKADFRFRIGSVTKTFIATVLLQLSGE
HHCCCCHHEEECCCCCCEEEEECCCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCC
NRLNLDDSIEKWLPGVIQGNGYDGNQITIRQILNHTSGIADYINSKDFDIMDIKKSYTAE
CCCCCCHHHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECHHHCCHH
EFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVENRIIEPLDLSNTFL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
PGNSSVIPGTKHARGYLQRDGASELKDVTYINPGSSDGDMISTADDLNKFFSYLLGGKLL
CCCCCCCCCCHHHHHHHHCCCHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHH
KEQQLKQMLTTVPTEREGTGYGLGILEIKLPNGVSVWGHRGGVPGFSTFVGGTLGGKHTL
HHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHCCCCCCCEEE
AVNLNSFNFSNPDPFKSILLAEFRK
EEEECCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKTHSKITCASLALLIAGSSLLYITPASIVKAEPTQNVSSSLQTSMQSDRTSVKKAIRDA
CCCCCHHHHHHHHHHHHCCCEEEECCHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LQLGYPGILANISKGGKTWSYTAGLADVRTKKPMKADFRFRIGSVTKTFIATVLLQLSGE
HHCCCCHHEEECCCCCCEEEEECCCHHHHCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCC
NRLNLDDSIEKWLPGVIQGNGYDGNQITIRQILNHTSGIADYINSKDFDIMDIKKSYTAE
CCCCCCHHHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECHHHCCHH
EFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTGNSYAEEVENRIIEPLDLSNTFL
HHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHCCCHHHHHHHHHCCCCCCCCCCCC
PGNSSVIPGTKHARGYLQRDGASELKDVTYINPGSSDGDMISTADDLNKFFSYLLGGKLL
CCCCCCCCCCHHHHHHHHCCCHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCHHH
KEQQLKQMLTTVPTEREGTGYGLGILEIKLPNGVSVWGHRGGVPGFSTFVGGTLGGKHTL
HHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEECCCCCCCCCHHHHHCCCCCCCEEE
AVNLNSFNFSNPDPFKSILLAEFRK
EEEECCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]