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The map label for this gene is relA [H]

Identifier: 52143035

GI number: 52143035

Start: 2330931

End: 2332319

Strand: Reverse

Name: relA [H]

Synonym: BCZK2203

Alternate gene names: 52143035

Gene position: 2332319-2330931 (Counterclockwise)

Preceding gene: 52143029

Following gene: 52143038

Centisome position: 44.0

GC content: 28.44

Gene sequence:

>1389_bases
ATGAGCGAGGTATTATTACAAAAGGCGAATTATTTACAGTCTAATGAATTAAATTTTTTGAAAAAAGCTATACAATTTGC
AGAGCGAGCACATGATGGACAATACCGTCAAACCGGAGAACCATATATTATTCACCCTTTCGCAATTGCAGAAATACTGA
TAAATTATAAAGCTGACATCACTACATTGATTGCTGCATTATTACACGATGTTGTAGAAGATACAGAATATTCTTTAGAA
GAAATTGAATCATATTTTGGTACAACTATTAGATATATTGTAAATGGATTAACAAAAGAAAAAAAACAACAAGATCAAAA
CAAAATAATATACGAAGCAATTAATTTTAAAAAACTACTATTATCCTCTCAACATGATATACGTGTTGGCATTATTAAAG
TTATAGATCGCCTTCACAATATAACAACATTGAATGTTAAAAAACCGGCGAAACAAGTAGCATATGCGAATGAAACTTTA
ACACTTTTTGCGCCACTTGCAAAGCGACTAGGATTATATACAATCCAGTATGAATTAGAAAATCTTGCTTTTCAATATTT
ACATAAAGAAAGATATAACAAGGTACTTGAATTTTTAACTGGATATGTGCCACATCTTCAAAAAAATATAACTGATTTAA
GAAGAGCAATTCATTCTTTTTATGATACTAACCTTTCATTTGAAATAAGCTATGAGTTCCCTCCAATTTATACTGCTTAC
TCACAACTACAAGAAATGCAAAACGTATCAGGTATTTCACAAATTTGTATTACAACTACAAGTGTACTAGATTGCTATAA
AATTCTTGGAATAATACATCAATTATACAAACCAGCTATCAACTATTTCGAAGACAACATAGCACTTGAAAACAGCCATT
TTAATAGCAATTTAAAAACTAAAATCAATATGAATGATACTGAACAAACAATTATCATTCAAACAAAACTTGCAAAAAGA
TTAAAAAATAATGGTATTTTTTCTTTATTGAATAATGAAACTATGGATATTCAATCCATATCTTATAAAATAATGAATGA
TACAATTGTGAATAACAATTTATTAACTACAGATCCAATCGCTTTCCATAATCTAGTATCATATGAACTATTTGAAAATA
CCATAACGGCCTATACTTCAGATTTACAACCTATTTATTTACCAGATGGTGCTACAATTATTGATTTTACTTTCTCTGCA
TTTCCAAAAATTGCACATAACATGAAAAATGCAAAAGTAAATGGTATACCTGTTCCACTTAAAACAAAGGTATCCCATTT
TGACGTCATAGAAATCTACTTTGATATAAAACAAAACTTGGTATTAGATTGGCTCAATTATGCCAATACCGCTAAAGCAC
AATTAATTATTCAGCAAAAACTATCATAA

Upstream 100 bases:

>100_bases
CTCAACACCTTTATTTATTTCATAATTAAAATAATTTCAAAGGGTATTTATTCTATTATACAGAATTATTATTAAAAATA
ATTTTAAAGGATGGATTTAT

Downstream 100 bases:

>100_bases
AAAACAGACCAATGCTTCTTATAAAAAGTATTGATCTGTTTTTTATGATACGAAATACACCCCATATTCTTTATGGAATA
AGCAAATTTAATACGATACC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSEVLLQKANYLQSNELNFLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADITTLIAALLHDVVEDTEYSLE
EIESYFGTTIRYIVNGLTKEKKQQDQNKIIYEAINFKKLLLSSQHDIRVGIIKVIDRLHNITTLNVKKPAKQVAYANETL
TLFAPLAKRLGLYTIQYELENLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRAIHSFYDTNLSFEISYEFPPIYTAY
SQLQEMQNVSGISQICITTTSVLDCYKILGIIHQLYKPAINYFEDNIALENSHFNSNLKTKINMNDTEQTIIIQTKLAKR
LKNNGIFSLLNNETMDIQSISYKIMNDTIVNNNLLTTDPIAFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSA
FPKIAHNMKNAKVNGIPVPLKTKVSHFDVIEIYFDIKQNLVLDWLNYANTAKAQLIIQQKLS

Sequences:

>Translated_462_residues
MSEVLLQKANYLQSNELNFLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADITTLIAALLHDVVEDTEYSLE
EIESYFGTTIRYIVNGLTKEKKQQDQNKIIYEAINFKKLLLSSQHDIRVGIIKVIDRLHNITTLNVKKPAKQVAYANETL
TLFAPLAKRLGLYTIQYELENLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRAIHSFYDTNLSFEISYEFPPIYTAY
SQLQEMQNVSGISQICITTTSVLDCYKILGIIHQLYKPAINYFEDNIALENSHFNSNLKTKINMNDTEQTIIIQTKLAKR
LKNNGIFSLLNNETMDIQSISYKIMNDTIVNNNLLTTDPIAFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSA
FPKIAHNMKNAKVNGIPVPLKTKVSHFDVIEIYFDIKQNLVLDWLNYANTAKAQLIIQQKLS
>Mature_461_residues
SEVLLQKANYLQSNELNFLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADITTLIAALLHDVVEDTEYSLEE
IESYFGTTIRYIVNGLTKEKKQQDQNKIIYEAINFKKLLLSSQHDIRVGIIKVIDRLHNITTLNVKKPAKQVAYANETLT
LFAPLAKRLGLYTIQYELENLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRAIHSFYDTNLSFEISYEFPPIYTAYS
QLQEMQNVSGISQICITTTSVLDCYKILGIIHQLYKPAINYFEDNIALENSHFNSNLKTKINMNDTEQTIIIQTKLAKRL
KNNGIFSLLNNETMDIQSISYKIMNDTIVNNNLLTTDPIAFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSAF
PKIAHNMKNAKVNGIPVPLKTKVSHFDVIEIYFDIKQNLVLDWLNYANTAKAQLIIQQKLS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=140, Percent_Identity=35, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790082, Length=461, Percent_Identity=30.1518438177874, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI1789147, Length=433, Percent_Identity=22.4018475750577, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25143118, Length=137, Percent_Identity=34.3065693430657, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 53237; Mature: 53106

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLLQKANYLQSNELNFLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADI
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHCCCHH
TTLIAALLHDVVEDTEYSLEEIESYFGTTIRYIVNGLTKEKKQQDQNKIIYEAINFKKLL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSSQHDIRVGIIKVIDRLHNITTLNVKKPAKQVAYANETLTLFAPLAKRLGLYTIQYELE
HCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHCCCHHHHHHHHHHHHCEEEEEEHHH
NLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRAIHSFYDTNLSFEISYEFPPIYTAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SQLQEMQNVSGISQICITTTSVLDCYKILGIIHQLYKPAINYFEDNIALENSHFNSNLKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEE
KINMNDTEQTIIIQTKLAKRLKNNGIFSLLNNETMDIQSISYKIMNDTIVNNNLLTTDPI
EEECCCCCCEEEEEHHHHHHHHCCCCEEEECCCCCCHHHHHEEEECCEEECCCCCCCCCH
AFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSAFPKIAHNMKNAKVNGIPVPL
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
KTKVSHFDVIEIYFDIKQNLVLDWLNYANTAKAQLIIQQKLS
CCCCCCCEEEHEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SEVLLQKANYLQSNELNFLKKAIQFAERAHDGQYRQTGEPYIIHPFAIAEILINYKADI
CHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHCCCHH
TTLIAALLHDVVEDTEYSLEEIESYFGTTIRYIVNGLTKEKKQQDQNKIIYEAINFKKLL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSSQHDIRVGIIKVIDRLHNITTLNVKKPAKQVAYANETLTLFAPLAKRLGLYTIQYELE
HCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHHHCCCHHHHHHHHHHHHCEEEEEEHHH
NLAFQYLHKERYNKVLEFLTGYVPHLQKNITDLRRAIHSFYDTNLSFEISYEFPPIYTAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHH
SQLQEMQNVSGISQICITTTSVLDCYKILGIIHQLYKPAINYFEDNIALENSHFNSNLKT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCEE
KINMNDTEQTIIIQTKLAKRLKNNGIFSLLNNETMDIQSISYKIMNDTIVNNNLLTTDPI
EEECCCCCCEEEEEHHHHHHHHCCCCEEEECCCCCCHHHHHEEEECCEEECCCCCCCCCH
AFHNLVSYELFENTITAYTSDLQPIYLPDGATIIDFTFSAFPKIAHNMKNAKVNGIPVPL
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCC
KTKVSHFDVIEIYFDIKQNLVLDWLNYANTAKAQLIIQQKLS
CCCCCCCEEEHEEHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA