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The map label for this gene is vanR [H]

Identifier: 52142938

GI number: 52142938

Start: 2437564

End: 2438259

Strand: Reverse

Name: vanR [H]

Synonym: BCZK2302

Alternate gene names: 52142938

Gene position: 2438259-2437564 (Counterclockwise)

Preceding gene: 52142922

Following gene: 52142939

Centisome position: 46.0

GC content: 31.32

Gene sequence:

>696_bases
ATGAATAAAAATATATTAATTATTGATGACGATAAAGAAATTGTTGAATTACTTGCTGTTTATTTGCGAAATGAAGGCTA
TAACATTTATAAAGCATATGATGGCGATGAAGCATTACAAATGATTTCTACATATGAAGTTGACCTTATGATTTTGGATA
TTATGATGCCAAAACGAAATGGATTAGAAGTTTGCCAAGAAGTTCGGGAAAATAATACTGTACCTATTCTTATGCTGAGT
GCAAAAGCAGAAGATATGGATAAAATATTAGGACTTATGACAGGCGCCGATGATTATATGATTAAACCATTTAATCCATT
AGAATTAGTAGCTAGAGTGAAAGCTTTGCTACGACGATCATCCTTCCAAAATGCCACTTCCCAAAAGAATGAAGATGGTA
TGATTCGCATTCGTTCTGCTGAAATACACAAACATAATCATACTGTGAAAGTAAATGGCGAATATATTAAGCTTACATCT
ATTGAATTTGATATTTTATATTTACTTGCGAGTAATACAGGAAGAGTATTTAGTTCTGAAGAAATATTTGAACGTGTTTG
GAATGAAGATGGTTATGGTTCAAATAAAACTGTAATGGTCCACATTAGTAATTTACGAGATAAGCTTGAAACAGGAATGA
ATGGAGAAAAATTTATTCATACTGTTTGGGGAGTAGGCTATAAAATTGAGAAATGA

Upstream 100 bases:

>100_bases
TAATACGTTACATGAAATTTTATACATAATCATCGCTACAAGTACATAAATGTTTGATATTATAGTAATGTTAATGATTT
GTAAGGAAAGGAACTACATA

Downstream 100 bases:

>100_bases
AGCATTTGATATATTAAAAGATATCCCGAAATGGAAACTTATTTTTTGGCTCTTATTAGCTATCACACTCACTCCTATTA
CTGAATTAATTATATATCGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNATSQKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK

Sequences:

>Translated_231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNATSQKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK
>Mature_231_residues
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLS
AKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRSSFQNATSQKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTS
IEFDILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=36.2445414847162, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.5545851528384, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.0396475770925, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=34.051724137931, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=32.7659574468085, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=30.9734513274336, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=229, Percent_Identity=31.8777292576419, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.1896551724138, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=33.6322869955157, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=31.7180616740088, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=34.2105263157895, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1790552, Length=226, Percent_Identity=33.1858407079646, Blast_Score=113, Evalue=9e-27,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=30.8370044052863, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.2576419213974, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1788550, Length=120, Percent_Identity=31.6666666666667, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=105, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=124, Percent_Identity=33.8709677419355, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26533; Mature: 26533

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCEEEEEEEEECCCCC
GLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRS
CHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SFQNATSQKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSE
HCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEEEEEEEEEEEECCCCCEECHH
EIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK
HHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHCCCEEECC
>Mature Secondary Structure
MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTYEVDLMILDIMMPKRN
CCCCEEEEECCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCEEEEEEEEECCCCC
GLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPFNPLELVARVKALLRRS
CHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHH
SFQNATSQKNEDGMIRIRSAEIHKHNHTVKVNGEYIKLTSIEFDILYLLASNTGRVFSSE
HCCCCCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEEEEEEEEEEEECCCCCEECHH
EIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTVWGVGYKIEK
HHHHHHCCCCCCCCCCEEEEEEHHHHHHHHCCCCHHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]