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The map label for this gene is proA [H]

Identifier: 52142531

GI number: 52142531

Start: 2827778

End: 2829025

Strand: Reverse

Name: proA [H]

Synonym: BCZK2711

Alternate gene names: 52142531

Gene position: 2829025-2827778 (Counterclockwise)

Preceding gene: 52142530

Following gene: 52142534

Centisome position: 53.37

GC content: 39.5

Gene sequence:

>1248_bases
ATGAATGAAGTGTTAGCAAAGGGAAAGAAGGCGAAAGAGATCGCTAGAGAGCTTGTGCTTAAATCTACAGAGCAAAAAAA
CGAAGCACTTTCCGCAATAGCTGATCAGTTAATATTAGAAACAGCTTATATTTTAGAAGAAAATAAGAAGGATATTGAAG
AAGGTAAGGCAAAAGGGTTTTCTGATTCTCTCCTTGATCGCCTTATGCTGAATGAACAGCGTATTGTTGATATGACAGAA
GGGATTAAGCAGCTAATTGAATTACGTGATCCTGTAGGAGACTGTGTAAGTGCATGGGAAAGGCCAAATGGACTATCTAT
TCAGGAAATGCGCGTACCACTTGGTGTTGTTGGGATGATTTACGAGGCAAGACCGAATGTAACAGTGGATGCTGCTACAA
TTTGTTTGAAGACAGGAAACGCAGTCATATTACGTGGTAGTTCTTCTGCTATTCATTCTAATAAAGCCATCGTTGCCGTT
ATTCACAGAGCGCTCAAACAAACAAGCTTACCTCAAGAAAGTGTACAGCTTATAGAAGATACAACGCGAGATAGCGCAAA
GCAGTTGTTTACAATGAATGATTATCTAGACGTTCTTATTCCAAGAGGTGGCAAGCAATTAATCGATACTGTTGTGAGGG
AAGCGTCTGTCCCAGTACTTGAAACAGGTGCGGGAAATTGTCATGTTTTCATTGATGAAACAGCGGATAAACAAATGGCA
TTTGATATTATTATAAATGCAAAAACGCAGCGTCCATCTGTATGTAATGCAATTGAAACGATTGTACTTCATGAGAAGTG
GGCAGAGCAATATGGTAGCGAGTTGTTTTCTTCTTTGAAGAAAAGAGGCGTGGAGCTACGTGGTGATCAAAAAGCATTAG
CAATGGATTCATCAATTGTACTTGCTTCAGAAGAAGACTGGGGGACGGAATTTCTATCTCTCACGCTAGCAGTTAAATTA
GTTTCTTCTATAGAAGAAGCGATTCATCACATAAATACGTATGGATCTATGCATTCTGAAGCGATTATTTCAGAAAACGA
GGAAAACGTCAGCAAATTTTTCGTATCTGTTGATGCTGCTGCGCTGTATCATAATGCATCAACTCGTTTTACTGATGGAT
ATGAATTCGGATTCGGAGCTGAGATTGGCATCAGTACACAAAAGCTACACGTAAGGGGACCAATGGGGCTTCCTGCATTA
ACTTCTATAAAATACGTCATTCGTGGAAATGGACAAATTCGAAAATAA

Upstream 100 bases:

>100_bases
AACATATTCAGGCAAGAGGCGAAAGGCATAGTTATGAAGTCATCCATAGAGATCATTGGGTTTCACTTTAATAAGAGGGA
TCAAAAAGGAGGAAATAAAA

Downstream 100 bases:

>100_bases
AAATAAAAGACACTCAATTCGTTTGGGTGTCTTTTATTTTAAAAATTATTTACCATACAAAAAGCCCAACAAGCATAGCA
CTTAATAAGGAAACAGCCAT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGDCVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKL
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGYEFGFGAEIGISTQKLHVRGPMGLPAL
TSIKYVIRGNGQIRK

Sequences:

>Translated_415_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGDCVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKL
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGYEFGFGAEIGISTQKLHVRGPMGLPAL
TSIKYVIRGNGQIRK
>Mature_415_residues
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGFSDSLLDRLMLNEQRIVDMTE
GIKQLIELRDPVGDCVSAWERPNGLSIQEMRVPLGVVGMIYEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAV
IHRALKQTSLPQESVQLIEDTTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIVLASEEDWGTEFLSLTLAVKL
VSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAAALYHNASTRFTDGYEFGFGAEIGISTQKLHVRGPMGLPAL
TSIKYVIRGNGQIRK

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=412, Percent_Identity=31.7961165048544, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI62912457, Length=412, Percent_Identity=31.7961165048544, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1786438, Length=411, Percent_Identity=43.7956204379562, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17569967, Length=409, Percent_Identity=34.2298288508557, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17569969, Length=409, Percent_Identity=34.2298288508557, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6324899, Length=427, Percent_Identity=37.2365339578454, Blast_Score=284, Evalue=1e-77,
Organism=Drosophila melanogaster, GI21357643, Length=411, Percent_Identity=33.8199513381995, Blast_Score=261, Evalue=5e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45672; Mature: 45672

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGF
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGDCVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHCCHHHHHHE
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCEE
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIV
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCEEE
LASEEDWGTEFLSLTLAVKLVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHH
ALYHNASTRFTDGYEFGFGAEIGISTQKLHVRGPMGLPALTSIKYVIRGNGQIRK
HHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCHHHHEEEEEECCCCCCC
>Mature Secondary Structure
MNEVLAKGKKAKEIARELVLKSTEQKNEALSAIADQLILETAYILEENKKDIEEGKAKGF
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCC
SDSLLDRLMLNEQRIVDMTEGIKQLIELRDPVGDCVSAWERPNGLSIQEMRVPLGVVGMI
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHCCHHHHHHE
YEARPNVTVDAATICLKTGNAVILRGSSSAIHSNKAIVAVIHRALKQTSLPQESVQLIED
EECCCCCEEEHEEEEEECCCEEEEECCCCCHHCCCHHHHHHHHHHHHCCCCHHHHHHHHH
TTRDSAKQLFTMNDYLDVLIPRGGKQLIDTVVREASVPVLETGAGNCHVFIDETADKQMA
HHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCCCEE
FDIIINAKTQRPSVCNAIETIVLHEKWAEQYGSELFSSLKKRGVELRGDQKALAMDSSIV
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHEEECCEEE
LASEEDWGTEFLSLTLAVKLVSSIEEAIHHINTYGSMHSEAIISENEENVSKFFVSVDAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHH
ALYHNASTRFTDGYEFGFGAEIGISTQKLHVRGPMGLPALTSIKYVIRGNGQIRK
HHHCCCCCCCCCCCCCCCCCEECCCEEEEEEECCCCCCHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA