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The map label for this gene is adp [C]

Identifier: 52142488

GI number: 52142488

Start: 2876237

End: 2877403

Strand: Reverse

Name: adp [C]

Synonym: BCZK2755

Alternate gene names: 52142488

Gene position: 2877403-2876237 (Counterclockwise)

Preceding gene: 52142486

Following gene: 52142487

Centisome position: 54.28

GC content: 37.79

Gene sequence:

>1167_bases
ATGAAAAAACGTAATTCAATGAAGTTAGCGAGTTTGACAGTTTTATTAGCGGGTACTACTCTATTTACACCTGATTTTAC
TGTGAAAGCAGAGTCTACTCAAAGTATTTCTAATTCGTCAAAAGTACATGATCAAAAGAATCAGAATGGCTGGAAACAAG
TATTGCAGGAAACAATCAAAATTGGAGCACCAGGGGTATTAGCTAAGACATCTAATAAAAGAAAAATTAGTAGTTATACT
GCTGGCGTAGCAGATTTAAGTACAAAGAAACCGATGAAATCAGATTATCGCTTTCGAATTGGTAGTGTGACGAAAAGTTT
TACCGCCACGACTGTTCTTCAATTAGTAGGGGAAAATCGCGTACAACTTGACGATCCAATTGAAAAGTGGCTGCCGGGTC
TCGTGCAAGGAAATGGGTATGATGGAAACCAAATTACGATACGACAACTTTTGAATCATACGAGTGGTATCGCTGAATAC
TTAAAGTCAAAAGACGCTGACGTAATGAATTCGAAAAAAACGTATACAGCAGAAGAAATAGTGAAAATAGGCCTTTCTCT
GCCTCCAGATTTCTCGCCGGGCAAAGACTGGTTGTATTCAAACACAGGATATGTAATATTGGGAATGCTAATTGAAAAAA
TAACTGGTAATAGTTATGCGGAAGAAATTGAAAATCGAATTATTGAACCTTTGGATTTGTCAAATACGTTTTTACCAGGA
AATTCACCCGTCATCCCAGGAAAGAATCATGCTCGTGGATATGTGAAAATGGAAGAAACAGGCGAGTTGAAAGACATTAC
GTATTATAATCCGAGTTTAGCTAATGCAGCTGGAGATATGATTTCTAATGCGGATGATTTAAACAAGTTCTTTTCATCTT
TACTCGGTGGTAAGTTATTGAAGGAACGCGAGCTAAAAGAAATGCTTACTACAGTTCCTGTAGAAGGAAAAGGGGTGGGT
GATGGATATGGTCTTGGAATCTATGAGACTAAACTTCCAAATGGTGTCTCAGTTTGGGGGCACGGAGGGTCAATTCCTGG
GTTTATGACTTTTGCTGGTGGGGTAATTGGAGGCAAGCATACATTTGCTGTCAGTGTTAACTCTTTAGGTCCAGTTGATA
TTCTTACACAGTTTGATAAAATGATGCAAGTTGAATTTAATAAATAA

Upstream 100 bases:

>100_bases
AGTATTTCGTAAGGAATGGATAAGAAAAAAGAGAGTTTTATCATATAGGATGAAAGTATAGCTTGAATCAATACGATATG
AATAGGGGAGAGAAATCCTT

Downstream 100 bases:

>100_bases
TAGATGAAAAGAGTTCTACTATAGAGGTATATAAGGACTTGTATGTGATTTAATTGTTATTAAAATATAGTCTTAAAAAA
CCCCGAATCATGAGCAATTT

Product: D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein)

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKKRNSMKLASLTVLLAGTTLFTPDFTVKAESTQSISNSSKVHDQKNQNGWKQVLQETIKIGAPGVLAKTSNKRKISSYT
AGVADLSTKKPMKSDYRFRIGSVTKSFTATTVLQLVGENRVQLDDPIEKWLPGLVQGNGYDGNQITIRQLLNHTSGIAEY
LKSKDADVMNSKKTYTAEEIVKIGLSLPPDFSPGKDWLYSNTGYVILGMLIEKITGNSYAEEIENRIIEPLDLSNTFLPG
NSPVIPGKNHARGYVKMEETGELKDITYYNPSLANAAGDMISNADDLNKFFSSLLGGKLLKERELKEMLTTVPVEGKGVG
DGYGLGIYETKLPNGVSVWGHGGSIPGFMTFAGGVIGGKHTFAVSVNSLGPVDILTQFDKMMQVEFNK

Sequences:

>Translated_388_residues
MKKRNSMKLASLTVLLAGTTLFTPDFTVKAESTQSISNSSKVHDQKNQNGWKQVLQETIKIGAPGVLAKTSNKRKISSYT
AGVADLSTKKPMKSDYRFRIGSVTKSFTATTVLQLVGENRVQLDDPIEKWLPGLVQGNGYDGNQITIRQLLNHTSGIAEY
LKSKDADVMNSKKTYTAEEIVKIGLSLPPDFSPGKDWLYSNTGYVILGMLIEKITGNSYAEEIENRIIEPLDLSNTFLPG
NSPVIPGKNHARGYVKMEETGELKDITYYNPSLANAAGDMISNADDLNKFFSSLLGGKLLKERELKEMLTTVPVEGKGVG
DGYGLGIYETKLPNGVSVWGHGGSIPGFMTFAGGVIGGKHTFAVSVNSLGPVDILTQFDKMMQVEFNK
>Mature_388_residues
MKKRNSMKLASLTVLLAGTTLFTPDFTVKAESTQSISNSSKVHDQKNQNGWKQVLQETIKIGAPGVLAKTSNKRKISSYT
AGVADLSTKKPMKSDYRFRIGSVTKSFTATTVLQLVGENRVQLDDPIEKWLPGLVQGNGYDGNQITIRQLLNHTSGIAEY
LKSKDADVMNSKKTYTAEEIVKIGLSLPPDFSPGKDWLYSNTGYVILGMLIEKITGNSYAEEIENRIIEPLDLSNTFLPG
NSPVIPGKNHARGYVKMEETGELKDITYYNPSLANAAGDMISNADDLNKFFSSLLGGKLLKERELKEMLTTVPVEGKGVG
DGYGLGIYETKLPNGVSVWGHGGSIPGFMTFAGGVIGGKHTFAVSVNSLGPVDILTQFDKMMQVEFNK

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=266, Percent_Identity=27.0676691729323, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082101, Length=157, Percent_Identity=28.0254777070064, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=308, Percent_Identity=25.974025974026, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533026, Length=362, Percent_Identity=25.9668508287293, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17565630, Length=293, Percent_Identity=26.962457337884, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42274; Mature: 42274

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRNSMKLASLTVLLAGTTLFTPDFTVKAESTQSISNSSKVHDQKNQNGWKQVLQETIK
CCCCCCCHHHHHEEHEECCEEECCCEEEECCCHHHHCCCHHHCCCCCCHHHHHHHHHHHH
IGAPGVLAKTSNKRKISSYTAGVADLSTKKPMKSDYRFRIGSVTKSFTATTVLQLVGENR
CCCCCEEEECCCCCCHHHHHCCHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCC
VQLDDPIEKWLPGLVQGNGYDGNQITIRQLLNHTSGIAEYLKSKDADVMNSKKTYTAEEI
CCCCCCHHHHCCHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHH
VKIGLSLPPDFSPGKDWLYSNTGYVILGMLIEKITGNSYAEEIENRIIEPLDLSNTFLPG
HHHCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCC
NSPVIPGKNHARGYVKMEETGELKDITYYNPSLANAAGDMISNADDLNKFFSSLLGGKLL
CCCCCCCCCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCHHHH
KERELKEMLTTVPVEGKGVGDGYGLGIYETKLPNGVSVWGHGGSIPGFMTFAGGVIGGKH
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHCCCCCCCE
TFAVSVNSLGPVDILTQFDKMMQVEFNK
EEEEEECCCCCHHHHHHHHHHHHEECCC
>Mature Secondary Structure
MKKRNSMKLASLTVLLAGTTLFTPDFTVKAESTQSISNSSKVHDQKNQNGWKQVLQETIK
CCCCCCCHHHHHEEHEECCEEECCCEEEECCCHHHHCCCHHHCCCCCCHHHHHHHHHHHH
IGAPGVLAKTSNKRKISSYTAGVADLSTKKPMKSDYRFRIGSVTKSFTATTVLQLVGENR
CCCCCEEEECCCCCCHHHHHCCHHHCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCC
VQLDDPIEKWLPGLVQGNGYDGNQITIRQLLNHTSGIAEYLKSKDADVMNSKKTYTAEEI
CCCCCCHHHHCCHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCHHHH
VKIGLSLPPDFSPGKDWLYSNTGYVILGMLIEKITGNSYAEEIENRIIEPLDLSNTFLPG
HHHCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCC
NSPVIPGKNHARGYVKMEETGELKDITYYNPSLANAAGDMISNADDLNKFFSSLLGGKLL
CCCCCCCCCCCCCEEEECCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHCHHHH
KERELKEMLTTVPVEGKGVGDGYGLGIYETKLPNGVSVWGHGGSIPGFMTFAGGVIGGKH
HHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCEEECCCCCCCHHHHHHCCCCCCCE
TFAVSVNSLGPVDILTQFDKMMQVEFNK
EEEEEECCCCCHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]