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The map label for this gene is mutX [H]

Identifier: 52142444

GI number: 52142444

Start: 2914988

End: 2915512

Strand: Reverse

Name: mutX [H]

Synonym: BCZK2799

Alternate gene names: 52142444

Gene position: 2915512-2914988 (Counterclockwise)

Preceding gene: 52142441

Following gene: 52142445

Centisome position: 55.0

GC content: 32.57

Gene sequence:

>525_bases
ATGTATAAGTACACAATTTGTTTCATTAGAAAAGGAAATAAAATACTCTTATTGAATAGAAATAAAAAGCCAAATATGGG
AATGTGGAATGGTGTTGGCGGAAAAATTGAAGATAATGAAACGCCATATGAAGGAATAATTAAAGAAACGCTTGAAGAAA
CAGGCATAGATCTTCCAAGTGTAACGTATAAAGGGAATGTGGTTTTTAAAAGTAAGGACGAGTCTCGAGGTAGTGAAGGA
ATGTATGTATTCCTTGCTGATCTGCCAGATGGAGTACATATGGACACGCCATTAAGTACGGCGGAAGGATTATTAGAATG
GAAAGAAATTGATTGGATATTAAATAAGGATAATAGAGGTGTAGTTAGCAATTTACCAAAATACTTACCAATAGTATTAA
CAGAAGAAAATAAGTTAGAGCATATATTCACATATGATAACGGGAATATTATTCATTACACAACTTCATTTTTGACAGAT
GATAATGCGAACAAACGGTATGAAAAACAACTCGTTTCTCAATAG

Upstream 100 bases:

>100_bases
AAAACCAGTTGTTTGTATAATAAGAATTTTTTTATGCAGCAAGTCTAATCAAAATGCTGTTTAAATTTTTAGATGAGGGG
AAAAGAAAGGAAAGAAACGT

Downstream 100 bases:

>100_bases
AAAAAATATGACAACAATCACTCTTATAATCTAGTAGATTGCAATTAGATAAGAAGTGGAATGATATAACCGTTCTTATT
ATGAAAGAGTAGAGAACATA

Product: MutT/Nudix family protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIKETLEETGIDLPSVTYKGNVVFKSKDESRGSEG
MYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIHYTTSFLTD
DNANKRYEKQLVSQ

Sequences:

>Translated_174_residues
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIKETLEETGIDLPSVTYKGNVVFKSKDESRGSEG
MYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIHYTTSFLTD
DNANKRYEKQLVSQ
>Mature_174_residues
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIKETLEETGIDLPSVTYKGNVVFKSKDESRGSEG
MYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRGVVSNLPKYLPIVLTEENKLEHIFTYDNGNIIHYTTSFLTD
DNANKRYEKQLVSQ

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 19942; Mature: 19942

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIKETLEETGIDLPS
CCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCC
VTYKGNVVFKSKDESRGSEGMYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRG
EEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHEEEEEEEEEECCCCC
VVSNLPKYLPIVLTEENKLEHIFTYDNGNIIHYTTSFLTDDNANKRYEKQLVSQ
HHHCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MYKYTICFIRKGNKILLLNRNKKPNMGMWNGVGGKIEDNETPYEGIIKETLEETGIDLPS
CCEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCC
VTYKGNVVFKSKDESRGSEGMYVFLADLPDGVHMDTPLSTAEGLLEWKEIDWILNKDNRG
EEEECCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHEEEEEEEEEECCCCC
VVSNLPKYLPIVLTEENKLEHIFTYDNGNIIHYTTSFLTDDNANKRYEKQLVSQ
HHHCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]