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The map label for this gene is ycgH [H]

Identifier: 52142409

GI number: 52142409

Start: 2948977

End: 2950320

Strand: Reverse

Name: ycgH [H]

Synonym: BCZK2833

Alternate gene names: 52142409

Gene position: 2950320-2948977 (Counterclockwise)

Preceding gene: 52142406

Following gene: 52142412

Centisome position: 55.66

GC content: 32.81

Gene sequence:

>1344_bases
ATGACCTGTCATGATGCTAAGAACGAAACGAAAGAAAAAAAAGATTTAAAATGGTGGCAACTCTCACTTATTGGGATTGG
TTGTACGATAGGGACGGGCTTTTTTTTAGGATCCAGTATAGGAATTAAAATAGGTGGTTCTTCAATTATTCTTATTCTTA
TTTTAACTGGGTTCACTACATATATTGTATTTGAGGCATTGGCAAAAATGGCTGTAGAAGATCCACAAAAAGGATCTTTT
CGCATTTATTCAAGAAAAGCTTTTGGAAATTGGGCGGGTTTTAGTCATGGATGGACATATTGGTGTTCTGAACTGCTTAT
TATGGGTAGTCAGTTAAGTGCGTTAGGAATCTTTTCACGCTACTGGTTTCCTAAAATACCCTTATGGATATTTGCTACTA
TATATGGAGTAGCGGCTATATTAATTATTTTTATAGGGGTAAAGATATTCGAACGTTTAGAGAAATGGATGGCTATTATA
AAAATCGCTGCTATTATAGGGTTTATTGTAATTGCTGTTTTAGTTATTTTAGGATTTATAAAGGGTGGTTTATATAAAGC
GCAAATCCCGCGTAATTTTAAAGACTGGTTCCCAAATGGATTAAAAGGCACTTGGTCCTCTCTAATTTATGCATTTTATG
CATTTGGAGGAATCGAAATTATGGGGTTAATGACAATAAGATTGAAAGACCCTAAAGATGCACAAAAATCAGGAAGAGTA
ATGTTAATGATTTTAACGATTATTTACGTAGTCTCTTTAGGGTTGGCAATTATGATGGTACCATTAAACCAGTTTAATAC
GAAAGAAAGCCCTTTTGTAATAGCGTTACAAGACTATAATTTGCCGTATGTACCATTTATTTTAAATGTAGTATTAATTT
TAGCGGGTTTTTCAACATTAGTTGGTTCATTATTTGCAGTGACAAGTGTACTAATGAACTTAGCTGAAGAAGGTGATGCA
CCTGCAATGTTTGCGAAAAAAAATAAGAAAAATATCTCTTTTCCAGCCCTAATTCTTATTATAATTGGACTTGGTGCTTC
TATCCTTAGTGCTTTATTACTACCAAAAAATATATATGAATATGTAACAACTGCAGCTGGATTAATGTTGTTATATACAT
GGAGTCTCATTCTTCTTTCATTTTGGAGATTAATGAATCCAAAAGGTTGGATGCAGATAAAAAGTATTATTGGTCTTATA
ATGATTGCACTAGCTGTTAGTGGAACGTTATTGCAAAAAACAACGCGTTTTGGTTTCTTAGTGAGCTTGTTGTTTTTAGG
AATAGTTATTATTGTTACTATAATTGTTCATTTTGTCTCAAGGAAAAGGAATACAGCTATATGA

Upstream 100 bases:

>100_bases
TAAAGGCTCATGATGTCATTGATGTTGTTGAAAAGCTTGCTGAGAAGTATTTAAGTGATCATGAGGGACATTCTCGAAAT
GAATAAAGGAGAATAGTAAT

Downstream 100 bases:

>100_bases
AGAATCTATTTTTACACAATATGAGTAGTATGTAACAACTAAATAATAGAAGCTATTGAAAAATGATTTGGTAAGTTTGA
AAACCAAAATATAATCCATA

Product: amino acid permease; proline permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MTCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSF
RIYSRKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIIGFIVIAVLVILGFIKGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNTAI

Sequences:

>Translated_447_residues
MTCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSF
RIYSRKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIGVKIFERLEKWMAII
KIAAIIGFIVIAVLVILGFIKGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDA
PAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLI
MIALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNTAI
>Mature_446_residues
TCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTTYIVFEALAKMAVEDPQKGSFR
IYSRKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSRYWFPKIPLWIFATIYGVAAILIIFIGVKIFERLEKWMAIIK
IAAIIGFIVIAVLVILGFIKGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRVM
LMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTLVGSLFAVTSVLMNLAEEGDAP
AMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYEYVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIM
IALAVSGTLLQKTTRFGFLVSLLFLGIVIIVTIIVHFVSRKRNTAI

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Proline. [C]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786602, Length=458, Percent_Identity=30.1310043668122, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1786302, Length=387, Percent_Identity=28.1653746770026, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1790653, Length=399, Percent_Identity=28.5714285714286, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=26.7156862745098, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786789, Length=381, Percent_Identity=28.0839895013123, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=23.4782608695652, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789017, Length=379, Percent_Identity=26.6490765171504, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI48994972, Length=387, Percent_Identity=27.390180878553, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1788480, Length=399, Percent_Identity=26.8170426065163, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17532491, Length=389, Percent_Identity=23.1362467866324, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324061, Length=406, Percent_Identity=27.0935960591133, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320772, Length=394, Percent_Identity=26.3959390862944, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6324990, Length=404, Percent_Identity=26.7326732673267, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320251, Length=397, Percent_Identity=25.4408060453401, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319542, Length=393, Percent_Identity=25.9541984732824, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320717, Length=407, Percent_Identity=24.5700245700246, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321053, Length=412, Percent_Identity=24.7572815533981, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319824, Length=399, Percent_Identity=25.062656641604, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6322892, Length=339, Percent_Identity=27.1386430678466, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321629, Length=403, Percent_Identity=22.8287841191067, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324924, Length=382, Percent_Identity=24.3455497382199, Blast_Score=100, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=25.3807106598985, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322967, Length=335, Percent_Identity=24.7761194029851, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324059, Length=357, Percent_Identity=22.96918767507, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319608, Length=353, Percent_Identity=22.9461756373938, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319543, Length=406, Percent_Identity=22.9064039408867, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667468, Length=414, Percent_Identity=22.9468599033816, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666159, Length=337, Percent_Identity=20.4747774480712, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221512776, Length=337, Percent_Identity=20.4747774480712, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49653; Mature: 49522

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTT
CCCCCCCCHHHHHHCCHHHEEEEEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRIYSRKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSR
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
YWFPKIPLWIFATIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIIGFIVIAVLVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSRKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TCHDAKNETKEKKDLKWWQLSLIGIGCTIGTGFFLGSSIGIKIGGSSIILILILTGFTT
CCCCCCCHHHHHHCCHHHEEEEEEEHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
YIVFEALAKMAVEDPQKGSFRIYSRKAFGNWAGFSHGWTYWCSELLIMGSQLSALGIFSR
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
YWFPKIPLWIFATIYGVAAILIIFIGVKIFERLEKWMAIIKIAAIIGFIVIAVLVILGFI
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGGLYKAQIPRNFKDWFPNGLKGTWSSLIYAFYAFGGIEIMGLMTIRLKDPKDAQKSGRV
HCCCEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHCCCC
MLMILTIIYVVSLGLAIMMVPLNQFNTKESPFVIALQDYNLPYVPFILNVVLILAGFSTL
HHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
VGSLFAVTSVLMNLAEEGDAPAMFAKKNKKNISFPALILIIIGLGASILSALLLPKNIYE
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
YVTTAAGLMLLYTWSLILLSFWRLMNPKGWMQIKSIIGLIMIALAVSGTLLQKTTRFGFL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VSLLFLGIVIIVTIIVHFVSRKRNTAI
HHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]