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The map label for this gene is gnd [H]

Identifier: 52142161

GI number: 52142161

Start: 3209474

End: 3210367

Strand: Reverse

Name: gnd [H]

Synonym: BCZK3081

Alternate gene names: 52142161

Gene position: 3210367-3209474 (Counterclockwise)

Preceding gene: 52142162

Following gene: 52142160

Centisome position: 60.56

GC content: 37.58

Gene sequence:

>894_bases
ATGCAAGTAGGATTAATTGGTTTAGGTAAAATGGGATTAAACTTAGGGAAAAATTTAATGGATCATAAACATGAAGTAGC
AGCATTTGATTTGAATGCAAGCGCAGTGGAAGAAATGAAAGAGTACGGGGCAACAGGTGCATCTAGTTTAAATGAACTTG
TTCAGTCATTACAATCACCAAGAGTTCTTTGGGTTATGGTACCACACGCTGTTGTAGATTCTGTTATTGATGAGGTTACA
CCACTTTTATCAAAAGGAGATATTTTAATTGAAGCGGGTAATTCACATTATAAAGAGTCAATTCGCCGATATGAGCAACT
AAAGAAAGATGGTATTCACTTTATGGATGCAGGAACTTCTGGCGGAATGGAAGGTGCTCGTAATGGTGCTTGTTATATGA
TCGGAGGAGATCAAGAAGCTTGGGACATCGTTGAACCTATCTTCCGTGATACTGCTGTAGAAAATGGATACTTATATGCT
GGAAAAGCTGGTAGTGGTCACTTCTTAAAAATGGTTCACAACGGAATTGAATACGGTATGATGGCTGCTATTGGTGAAGG
ATTTGAGATTCTAGAGAAAAGTGAATTTGACTACGATTATGAAAAAGTATCAAGAGTATGGAACAACGGTTCAGTAATCC
GTTCATGGTTAATGGAATTAACAGAAAATGCATTTTCTAAAGATGCAAAACTAGATGAAATTAAGGGTGTTATGCATTCT
TCTGGTGAAGGAAAATGGACAGTAGAAACAGCATTAGACCTTCAAACAGCAACTCCTGTTATCGCAATGTCGTTATTAAT
GCGCTACCGCTCATTAGACAATGATACATTTACAGGAAAAGTAGTAGCTGCTCTGCGCAATGAATTTGGCGGACATGCAG
TAGAAAAGAAATAA

Upstream 100 bases:

>100_bases
TGACTGTGAATACCTTTCCGTACATATCAGTGCTGCAAGGTATTCCAGATTGTAGTGATATGAATTTTTAATAAAAGAGG
ATTTGAGGAGGAATTATATT

Downstream 100 bases:

>100_bases
ACATCTTAAAAATTTAACTCATTGACGTTTAAAAAATGGAGGGAATTAATCATGAAATTTTTTATTGATACTGCAAATCT
TGAGGACATAAAAAAAGCAT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGASSLNELVQSLQSPRVLWVMVPHAVVDSVIDEVT
PLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTSGGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGYLYA
GKAGSGHFLKMVHNGIEYGMMAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK

Sequences:

>Translated_297_residues
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGASSLNELVQSLQSPRVLWVMVPHAVVDSVIDEVT
PLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTSGGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGYLYA
GKAGSGHFLKMVHNGIEYGMMAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK
>Mature_297_residues
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGASSLNELVQSLQSPRVLWVMVPHAVVDSVIDEVT
PLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTSGGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGYLYA
GKAGSGHFLKMVHNGIEYGMMAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=291, Percent_Identity=37.4570446735395, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI23308751, Length=177, Percent_Identity=27.683615819209, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788341, Length=318, Percent_Identity=34.5911949685535, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI145693186, Length=208, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790315, Length=202, Percent_Identity=24.7524752475248, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17542558, Length=290, Percent_Identity=37.9310344827586, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321695, Length=294, Percent_Identity=39.4557823129252, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321977, Length=306, Percent_Identity=38.8888888888889, Blast_Score=175, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24639279, Length=289, Percent_Identity=35.9861591695502, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24655230, Length=221, Percent_Identity=25.3393665158371, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19922568, Length=221, Percent_Identity=25.3393665158371, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32635; Mature: 32635

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGASSLNELVQSLQSP
CCEEEEECCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC
RVLWVMVPHAVVDSVIDEVTPLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTS
CEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCC
GGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGYLYAGKAGSGHFLKMVHNGIEYGM
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCHHHHH
MAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
HHHHCCCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MQVGLIGLGKMGLNLGKNLMDHKHEVAAFDLNASAVEEMKEYGATGASSLNELVQSLQSP
CCEEEEECCHHHHHHHHHHHHCCHHHEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHCCC
RVLWVMVPHAVVDSVIDEVTPLLSKGDILIEAGNSHYKESIRRYEQLKKDGIHFMDAGTS
CEEEEECCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCC
GGMEGARNGACYMIGGDQEAWDIVEPIFRDTAVENGYLYAGKAGSGHFLKMVHNGIEYGM
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHCCHHHHH
MAAIGEGFEILEKSEFDYDYEKVSRVWNNGSVIRSWLMELTENAFSKDAKLDEIKGVMHS
HHHHCCCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SGEGKWTVETALDLQTATPVIAMSLLMRYRSLDNDTFTGKVVAALRNEFGGHAVEKK
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]