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The map label for this gene is qor [C]

Identifier: 52142155

GI number: 52142155

Start: 3217320

End: 3218315

Strand: Direct

Name: qor [C]

Synonym: BCZK3087

Alternate gene names: 52142155

Gene position: 3217320-3218315 (Clockwise)

Preceding gene: 52142166

Following gene: 52142153

Centisome position: 60.69

GC content: 38.45

Gene sequence:

>996_bases
ATGAAAGCACAAATTATCCATTCTTTTGGAGATTCATCTGTATTTCAATTAGAAGAAGTTGCAAAACCGAAACTTTTACC
CGGTCATGTTCTAATTCATGTAAAAGCAACAAGTGTAAATCCAATCGATACGAAAATGCGCAGTGGCGCTGTTTCATCAG
TTGCTCCTGAATTTCCAGCTATATTACACGGGGATGTAGCAGGTATTGTTATAGAAGTAGGAGAAGGCGTTTCAAAATTC
AAAACTGGTGATGAAGTATATGGATGTGCCGGAGGTTTTAAAGAAACTGGTGGTGCACTTGCAGAGTTTATGCTTGCTGA
TGCGCGATTAATTGCTCATAAACCTAAAAATGTAACAATGGAAGAAGCAGCTGCCCTACCATTAGTTGCAATTACAGCTT
GGGAATCTTTATTTGATCGTGCAAATATGAAATCAGGTCAAAATGTGCTCATTCATGGAGCTACTGGTGGCGTAGGACAC
GTAGCCATTCAATTAGCTAAATGGGCTGGTGCTAAAGTTTTTACAACTGCTTCTCAGCAGAACAAAATGGAAATAGCCCA
TCGTCTAGGAGCCGACATAGCTATTAACTATAAAGAAGAATCTGTTCAAGAATATGTTCAAAAACATACGAATGGCAACG
GATTTGAAGTTATATTTGATACAGTAGGTGGCAAGAATCTCGATAACTCTTTCGAAGCTGCTGCAGTCAACGGAACTGTC
GTAACAATTGCAGCTCGTTCAACCCATGACCTCTCTCCTTTACACGCAAAAGGACTCTCTCTGCACGTTACTTTTATGGC
GTTAAAAATATTACATACAGATAAGCGTAATGATTGCGGAGAAATCTTAACGAAAATAACGCAAATTGTAGAAGAAGGAA
AACTTCGCCCATTGCTAGATTCTAAATCTTTTACGTTTGATGAAGTCGCACAAGCACATGAATATTTGGAATCGAATAAA
GCAATTGGAAAAATAGTGTTGAAAAACGTTTGGTAA

Upstream 100 bases:

>100_bases
TCCTCTTCTTTATATAAAATTCTCACTAACCAAATTCAAAATATTATACTTATTTTTTGTACTTTGCTATGCTATAACCA
CGAACAGGAGGTAAGGACCA

Downstream 100 bases:

>100_bases
CTATAATCCGATAAAAATAATGATTGCTCGTTGCTAGAAAGTAACAGAATAAATAAGCTTCCTTTATTGCTAACATCATT
TATCAAATTTCATGCTTCCA

Product: quinone oxidoreductase (NADPH:quinone reductase)

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPAILHGDVAGIVIEVGEGVSKF
KTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNVTMEEAAALPLVAITAWESLFDRANMKSGQNVLIHGATGGVGH
VAIQLAKWAGAKVFTTASQQNKMEIAHRLGADIAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLDSKSFTFDEVAQAHEYLESNK
AIGKIVLKNVW

Sequences:

>Translated_331_residues
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPAILHGDVAGIVIEVGEGVSKF
KTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNVTMEEAAALPLVAITAWESLFDRANMKSGQNVLIHGATGGVGH
VAIQLAKWAGAKVFTTASQQNKMEIAHRLGADIAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLDSKSFTFDEVAQAHEYLESNK
AIGKIVLKNVW
>Mature_331_residues
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPAILHGDVAGIVIEVGEGVSKF
KTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNVTMEEAAALPLVAITAWESLFDRANMKSGQNVLIHGATGGVGH
VAIQLAKWAGAKVFTTASQQNKMEIAHRLGADIAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLDSKSFTFDEVAQAHEYLESNK
AIGKIVLKNVW

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=361, Percent_Identity=33.7950138504155, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI22538446, Length=327, Percent_Identity=32.4159021406728, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI22538444, Length=327, Percent_Identity=32.4159021406728, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI194239674, Length=329, Percent_Identity=28.8753799392097, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI13236495, Length=329, Percent_Identity=28.8753799392097, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI194239676, Length=329, Percent_Identity=27.355623100304, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI18379349, Length=323, Percent_Identity=28.4829721362229, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI41872631, Length=238, Percent_Identity=29.4117647058824, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI24308257, Length=350, Percent_Identity=25.4285714285714, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI28557745, Length=246, Percent_Identity=30.8943089430894, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI197927207, Length=192, Percent_Identity=26.0416666666667, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI90669511, Length=195, Percent_Identity=31.2820512820513, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI226059159, Length=144, Percent_Identity=28.4722222222222, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI226059133, Length=144, Percent_Identity=28.4722222222222, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI226056130, Length=144, Percent_Identity=28.4722222222222, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI67078404, Length=217, Percent_Identity=26.2672811059908, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1790485, Length=328, Percent_Identity=29.8780487804878, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17507255, Length=331, Percent_Identity=29.9093655589124, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71987554, Length=358, Percent_Identity=29.608938547486, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI212642053, Length=242, Percent_Identity=28.099173553719, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17556000, Length=197, Percent_Identity=29.4416243654822, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17536829, Length=249, Percent_Identity=27.710843373494, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323801, Length=330, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319520, Length=336, Percent_Identity=27.6785714285714, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=29.6028880866426, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=252, Percent_Identity=28.1746031746032, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320948, Length=399, Percent_Identity=23.3082706766917, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319401, Length=262, Percent_Identity=27.0992366412214, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=345, Percent_Identity=24.0579710144928, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=23.4604105571848, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24581341, Length=368, Percent_Identity=26.3586956521739, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24581339, Length=368, Percent_Identity=26.6304347826087, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24581345, Length=242, Percent_Identity=30.1652892561983, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI19920632, Length=236, Percent_Identity=28.3898305084746, Blast_Score=98, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221330659, Length=236, Percent_Identity=28.3898305084746, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35544; Mature: 35544

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPA
CCCEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHCCCHHHCCCCCCC
ILHGDVAGIVIEVGEGVSKFKTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNVTM
CCCCCCEEEEEECCCCHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCH
EEAAALPLVAITAWESLFDRANMKSGQNVLIHGATGGVGHVAIQLAKWAGAKVFTTASQQ
HHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCH
NKMEIAHRLGADIAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
HHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCEE
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLD
EEEEECCCCCCCCHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SKSFTFDEVAQAHEYLESNKAIGKIVLKNVW
CCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MKAQIIHSFGDSSVFQLEEVAKPKLLPGHVLIHVKATSVNPIDTKMRSGAVSSVAPEFPA
CCCEEEECCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHCCCHHHCCCCCCC
ILHGDVAGIVIEVGEGVSKFKTGDEVYGCAGGFKETGGALAEFMLADARLIAHKPKNVTM
CCCCCCEEEEEECCCCHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCCCH
EEAAALPLVAITAWESLFDRANMKSGQNVLIHGATGGVGHVAIQLAKWAGAKVFTTASQQ
HHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCH
NKMEIAHRLGADIAINYKEESVQEYVQKHTNGNGFEVIFDTVGGKNLDNSFEAAAVNGTV
HHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCEE
VTIAARSTHDLSPLHAKGLSLHVTFMALKILHTDKRNDCGEILTKITQIVEEGKLRPLLD
EEEEECCCCCCCCHHHCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
SKSFTFDEVAQAHEYLESNKAIGKIVLKNVW
CCCCCHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA