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The map label for this gene is pbp [H]

Identifier: 52142081

GI number: 52142081

Start: 3287944

End: 3288981

Strand: Direct

Name: pbp [H]

Synonym: BCZK3161

Alternate gene names: 52142081

Gene position: 3287944-3288981 (Clockwise)

Preceding gene: 52142083

Following gene: 52142076

Centisome position: 62.03

GC content: 35.74

Gene sequence:

>1038_bases
ATGAACTTAAAAAGTAACAATATATACGAAAAAATGCACCAATATTCCGTTGCAGGTTTAAGTCTTGCTGTTATACACGA
CGGCAAACTAGATGAAACAGCTGCTTTCGGAACACTTGAATCCGGAACTAATAGAACTGTCACTACAGATTCCATATTCA
ATTCTTGTTCTATTAGCAAATTTATCACCACAATTCTCGTACTAACATTATCCGATCAGAAAATCGTACATTTAGATGAA
GACGTAAATGATAGACTCACATCTTGGAACATCCCTACCAATCTATTTACTTCACAAAAGAAGGTCACATTGCGAAACTT
GTTAAGTCACCAATCTGGAATCATTGACCCACCTAATAGTTTTGAACATTATACACTTGCACATGGACAACCAAGCATGT
CTAAACTCCTTGCCGGTAAAACACCATATTGCTCCGTACCGATAGAAGTAACTTATAAACCAGAAAGCGAATTTCACTAC
TCGGATGCAAACTTTTGTATAATCGAAATACTACTTGAAGATATAACTGGAAAGCCATTCAACCTTTTACTAGAAGAATA
TATATTTCAACCACTGCAAATGAAGAATAGTACAATCTTCTCTTCTAAAGACATAGATAAAACCGATGCTTTTGCTTGCG
GACATAATAAAGATAGCACCGTTACAAATGAGAAGTATCCATTTTATCCATTCGCAGCTGCTTCAGGTATTTGGACAACA
CCAACTGACTTATCAGCTTTAGTTATTGAAATCATTCATTCCTTACAAGGAAAAGGCAAACTAAAACTTTCTCAAAAAAC
AGTACAAGATATGATTTCTCCTCAAGGTTGCTCAAAATGGACTGGCTTAGGTGTTTTTCTAGATGATTCGAATGAAGACT
TACAAATTTATTCACTCGGATGGGGCGTTGGATTTCAATGTATGATGATATGCTATCCATACCGAGGTAATGGTGCTATT
ATAATGACGAACGCAGACTTAGGTGTTCATCAAATGGAAGGGATTATTGGTGACGTTTTAGAAACGTTATCCTTATAA

Upstream 100 bases:

>100_bases
TCATCGATAAAAGATGAAGTTTTTTCTTTTTCTCTCATTCTCTCTATTAAATACTTTATAATAGAACTAATATTCTGTCT
CTTCAAGGAAAGGAGTCACT

Downstream 100 bases:

>100_bases
TGAAAAGAAAGAAGCTGTTCCTTCCAGCTTCTTTACTTATATAACATTTTTCGCAACAATTTTTATATGTTCTGGTGCAA
TAATCTCCGTTATACTTTCT

Product: beta-lactamase

Products: substituted beta-amino acid

Alternate protein names: PBP-4 [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MNLKSNNIYEKMHQYSVAGLSLAVIHDGKLDETAAFGTLESGTNRTVTTDSIFNSCSISKFITTILVLTLSDQKIVHLDE
DVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYTLAHGQPSMSKLLAGKTPYCSVPIEVTYKPESEFHY
SDANFCIIEILLEDITGKPFNLLLEEYIFQPLQMKNSTIFSSKDIDKTDAFACGHNKDSTVTNEKYPFYPFAAASGIWTT
PTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDSNEDLQIYSLGWGVGFQCMMICYPYRGNGAI
IMTNADLGVHQMEGIIGDVLETLSL

Sequences:

>Translated_345_residues
MNLKSNNIYEKMHQYSVAGLSLAVIHDGKLDETAAFGTLESGTNRTVTTDSIFNSCSISKFITTILVLTLSDQKIVHLDE
DVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYTLAHGQPSMSKLLAGKTPYCSVPIEVTYKPESEFHY
SDANFCIIEILLEDITGKPFNLLLEEYIFQPLQMKNSTIFSSKDIDKTDAFACGHNKDSTVTNEKYPFYPFAAASGIWTT
PTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDSNEDLQIYSLGWGVGFQCMMICYPYRGNGAI
IMTNADLGVHQMEGIIGDVLETLSL
>Mature_345_residues
MNLKSNNIYEKMHQYSVAGLSLAVIHDGKLDETAAFGTLESGTNRTVTTDSIFNSCSISKFITTILVLTLSDQKIVHLDE
DVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNSFEHYTLAHGQPSMSKLLAGKTPYCSVPIEVTYKPESEFHY
SDANFCIIEILLEDITGKPFNLLLEEYIFQPLQMKNSTIFSSKDIDKTDAFACGHNKDSTVTNEKYPFYPFAAASGIWTT
PTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDSNEDLQIYSLGWGVGFQCMMICYPYRGNGAI
IMTNADLGVHQMEGIIGDVLETLSL

Specific function: Involved in cell wall biosynthesis and may also act as a sensor of external penicillins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-lactamase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI115533026, Length=361, Percent_Identity=27.1468144044321, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6

Molecular weight: Translated: 38276; Mature: 38276

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKSNNIYEKMHQYSVAGLSLAVIHDGKLDETAAFGTLESGTNRTVTTDSIFNSCSISK
CCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHCCCCCCCCCCEEEHHHHHCCCCHHH
FITTILVLTLSDQKIVHLDEDVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNS
HHHHHEEEEECCCEEEEECCCCCCCCEECCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCC
FEHYTLAHGQPSMSKLLAGKTPYCSVPIEVTYKPESEFHYSDANFCIIEILLEDITGKPF
CCCEEEECCCCHHHHHHCCCCCCEECCEEEEECCCCCEEECCCCHHHHEEHHHHHCCCHH
NLLLEEYIFQPLQMKNSTIFSSKDIDKTDAFACGHNKDSTVTNEKYPFYPFAAASGIWTT
HHHHHHHHCCCHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
PTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDSNEDLQIYSLG
CCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEEEC
WGVGFQCMMICYPYRGNGAIIMTNADLGVHQMEGIIGDVLETLSL
CCCCEEEEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLKSNNIYEKMHQYSVAGLSLAVIHDGKLDETAAFGTLESGTNRTVTTDSIFNSCSISK
CCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHCCCCCCCCCCEEEHHHHHCCCCHHH
FITTILVLTLSDQKIVHLDEDVNDRLTSWNIPTNLFTSQKKVTLRNLLSHQSGIIDPPNS
HHHHHEEEEECCCEEEEECCCCCCCCEECCCCCHHHCCCHHHHHHHHHHHCCCCCCCCCC
FEHYTLAHGQPSMSKLLAGKTPYCSVPIEVTYKPESEFHYSDANFCIIEILLEDITGKPF
CCCEEEECCCCHHHHHHCCCCCCEECCEEEEECCCCCEEECCCCHHHHEEHHHHHCCCHH
NLLLEEYIFQPLQMKNSTIFSSKDIDKTDAFACGHNKDSTVTNEKYPFYPFAAASGIWTT
HHHHHHHHCCCHHHCCCEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
PTDLSALVIEIIHSLQGKGKLKLSQKTVQDMISPQGCSKWTGLGVFLDDSNEDLQIYSLG
CCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEEEC
WGVGFQCMMICYPYRGNGAIIMTNADLGVHQMEGIIGDVLETLSL
CCCCEEEEEEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: beta-lactam; H2O

Specific reaction: A beta-lactam + H2O = a substituted beta-amino acid

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8440253 [H]