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The map label for this gene is argH [H]

Identifier: 52141985

GI number: 52141985

Start: 3384701

End: 3386209

Strand: Reverse

Name: argH [H]

Synonym: BCZK3258

Alternate gene names: 52141985

Gene position: 3386209-3384701 (Counterclockwise)

Preceding gene: 52141984

Following gene: 52141986

Centisome position: 63.88

GC content: 34.33

Gene sequence:

>1509_bases
ATGAAACAAAGCAAAGAAGAGTTTATCAAGAGTGAAGGCGCTGATTTCCCTGGGAAAACATATGTGGATTGTGTATTACA
ACATGTATTTAATTTTCAACGAAATTACTTATTGAAAGATATGTTTCAAGTGCATAAAGCACATATTGTGATGTTGACGG
AAGAAAATTTAATGAAAAAGGAAGAAGCTAAATTTATATTACACTCATTAAAAAAGGTTGAGGAAATTCCAGAAGAGCAA
TTGCTCTATACAGAGCAACATGAAGATCTCTTTTTTTTAGTGGAACATTTAATTTCTCAAGAAGCGAAAAGCGATTTTGT
AAGTAATATGCATATTGGTAGAAGTAGAAATGATATGGGTGTTACGATGTATCGCATGAGTTTAAGGCGATATGTGCTAC
GATTAATGGAACATCATTTGTTATTGCAAGAAAGTATATTGCAACTTGCTGCTGATCATAAGGAAACGATTATGCCAGCT
TATACACATACACAACCAGCTCAGCCAACAACATTTGGTCATTATATGTTAGCGATTTATGATACGATGCAGAGAGATTT
AGAACGCATGAAAAAAACGTACAAACTTTTAAATCAATCGCCAATGGGAGCTGCTGCGCTTTCTACAACAAGTTTCCCAA
TTAAACGAGAGCGAGTTGCCGATTTACTTGGATTTACTAATGTAATTGAGAACTCATATGATGCTGTCGCTGGAGCGGAT
TATTTATTAGAGGTTAGCTCGTTACTTATGGTAATGATGACGAATACGAGTAGATGGATTCATGATTTCTTACTATTAGC
GACGAAAGAATATGATGGTATTACTGTTGCAAGGCCGTATGTGCAAATTAGTAGTATTATGCCACAAAAGCGAAATCCAG
TTTCGATTGAACACGCCCGTGCAATTACGAGTAGTGCTCTAGGGGAAGCATTTACAGTATTTCAAATGATTCATAATACA
CCATTTGGTGATATTGTCGATACGGAAGATGACTTGCAGCCGTATTTATATAAAGGAATTGAAAAGGCTATTCGTGTATT
TTGCATTTTGAATGCAGTTATTCGAACGATGAAAGTAGAAGAGGATACCTTAAAAAGACGTTCATATAAACATGCAATTA
CGATTACAGATTTCGCAGATGCTTTAACGAAAAACTATGGCATTCCATTTCGGCATGCTCATCATGCGGCAAGTGTTATT
GCGAATATGTCGTTGGAACAGAAAAAGGAGCTACATGAATTATGTTTCAAAGATGTAAATATATACTTACAAGAAAATTT
TAAAATACAATTATTAGAAAAAGAGTGGGAAGAAATTATATCGCCAGAAGCTTTTATACAAAAAAGAAATGTATATGGTG
GACCGAGTAAAAAAGAAATGGAGCGCATGATTAACAATCGAAAAGAGTTATTTCGAAAAGAAGAAGGGGTATTTGAAAAG
GAAAAACAGAGGATTTTACAAGCTGAAAATGATTTGAATGTGTTAGCTTCGAATATTATTGAATCGTAA

Upstream 100 bases:

>100_bases
CTCGGTGCAGAGAGCACCGAGTTTATTTTTGTGTACAAGCACTTTTTCCCTATCTCTGGGTATGATGGGTAGTAATACTG
AGGTGAGAGGGGAAAAAGTG

Downstream 100 bases:

>100_bases
AAGAGGGATTTAATGAATTAATCGCCAATACTTAATAAAACTATAAATAGAGAGAAGAGATTGTCGATGATTCAATTACA
TGTATATGAAGAGGTTGTTA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHSLKKVEEIPEEQ
LLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYMLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADALTKNYGIPFRHAHHAASVI
ANMSLEQKKELHELCFKDVNIYLQENFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEGVFEK
EKQRILQAENDLNVLASNIIES

Sequences:

>Translated_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHSLKKVEEIPEEQ
LLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYMLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADALTKNYGIPFRHAHHAASVI
ANMSLEQKKELHELCFKDVNIYLQENFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEGVFEK
EKQRILQAENDLNVLASNIIES
>Mature_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHSLKKVEEIPEEQ
LLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPA
YTHTQPAQPTTFGHYMLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFADALTKNYGIPFRHAHHAASVI
ANMSLEQKKELHELCFKDVNIYLQENFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEGVFEK
EKQRILQAENDLNVLASNIIES

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=417, Percent_Identity=27.3381294964029, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI68303542, Length=417, Percent_Identity=27.3381294964029, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI68303547, Length=417, Percent_Identity=27.5779376498801, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI68303549, Length=417, Percent_Identity=25.4196642685851, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1790398, Length=417, Percent_Identity=28.2973621103118, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321806, Length=473, Percent_Identity=27.061310782241, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI221473854, Length=384, Percent_Identity=27.34375, Blast_Score=148, Evalue=1e-35,
Organism=Drosophila melanogaster, GI78706858, Length=384, Percent_Identity=27.34375, Blast_Score=148, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 58375; Mature: 58375

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHIVMLTEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHH
EEAKFILHSLKKVEEIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMG
HHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFGHYMLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHH
DTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHH
AITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDTLKRRSYKHAITITDFADALTKNYGIPFRHAHHAASVIANMSLEQKKELHELCFKDVN
HHHHHHHHHCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IYLQENFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEGVFEK
EEEECCCEEEEHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
EKQRILQAENDLNVLASNIIES
HHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFNFQRNYLLKDMFQVHKAHIVMLTEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHH
EEAKFILHSLKKVEEIPEEQLLYTEQHEDLFFLVEHLISQEAKSDFVSNMHIGRSRNDMG
HHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
VTMYRMSLRRYVLRLMEHHLLLQESILQLAADHKETIMPAYTHTQPAQPTTFGHYMLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCHHHHHHHHH
DTMQRDLERMKKTYKLLNQSPMGAAALSTTSFPIKRERVADLLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVARPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHH
AITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EDTLKRRSYKHAITITDFADALTKNYGIPFRHAHHAASVIANMSLEQKKELHELCFKDVN
HHHHHHHHHCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IYLQENFKIQLLEKEWEEIISPEAFIQKRNVYGGPSKKEMERMINNRKELFRKEEGVFEK
EEEECCCEEEEHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
EKQRILQAENDLNVLASNIIES
HHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]