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The map label for this gene is parC [H]

Identifier: 52141940

GI number: 52141940

Start: 3435499

End: 3437922

Strand: Reverse

Name: parC [H]

Synonym: BCZK3303

Alternate gene names: 52141940

Gene position: 3437922-3435499 (Counterclockwise)

Preceding gene: 52141939

Following gene: 52141941

Centisome position: 64.86

GC content: 37.09

Gene sequence:

>2424_bases
ATGCAAGCAGAGAAGTTTCATGACCTCCCGCTTGAAGACGTGTTAGGTGACCGCTTTGCACGTTATAGTAAATATATTAT
TCAAGATCGCGCACTTCCAGATGCGCGTGACGGCTTAAAACCAGTACAAAGACGTATTTTATATTCTATGTATGTAGAAG
GAAACGTACATGATAAAGCGTTCCGTAAGTCGGCTAAAACAGTCGGTAACGTTATTGGTAACTATCACCCGCACGGTGAT
TCCTCTGTATATGAAGCGATGGTACGTTTAAGTCAAACTTGGAAAGTACGTAATGTTTTAGTTGAGATGCATGGTAATAA
TGGTAGTGTTGACGGGGATCCGGCAGCAGCAATGCGTTATACGGAAGCCCGATTATCACCAATTGCATCTGAGTTATTAC
GTGATCTTGATAAAGAAACAGTAGAATTCGTATCTAATTTTGATGATACGAGTGAAGAACCGGTTGTTTTACCAGCAGCG
TTCCCGAACTTATTAGTGAACGGATCTACAGGAATTTCCGCTGGTTATGCAACAGAAATTCCTCCGCATCATCTTGGAGA
AGTTATTGACGCTACAATGATGCGTATTGATAAACCGAATAGTACTGTTGATGATTTATTAACAGTTATGAAAGGTCCAG
ATTTCCCAACAGGTGGTATTATTCAAGGGATTGATGGTATTAAAAAGGCGTATGAAACAGGTAAAGGTAAAATTATTATT
CGCGGGAAAGCAGAAGTTGAAACGGTTCGTGGCGGGAAACAGCAAATCGTAATTACTGAAATTCCATACGAAGTAAATAA
AGCAAACCTTGTTAAGAAAATGGATGAGTTACGTCTAGATAAAAAATTAGATGGTATTGCTGAAGTACGTGATGAGACAG
ATCGTACAGGTCTTCGCATTGTCGTAGAATTAAAAAAAGAAGCAAATTCTGAAGGTATTTTAAATTATTTATATAAAAAT
ACAGATTTACAAATTCCATATAACTTTAATATGGTAGCGATTAATAATCGTCGTCCAACGCTTATGACATTACCGAAAAT
TTTAGATGCATATATTGGCCATCAAAAAGAAGTTGTTACGAGACGTTCACAATATGAATTACGAAAGGCAGAAAATCGTC
AACATATTGTAGAAGGTTTAAAGAAAGCATTATCGATTTTAGACCAAGTTATTGAAACGATTCGAGCTTCAAAAGATAAG
CGTAATGCAAAAGATAATTTAAGTGCGAAATTTGGTTTTACAGAAGCGCAAGCGGAAGCAATTGTATCCTTGCAATTATA
TCGTTTAACGAATACAGATATTACAGCGCTACAACAAGAGGCAGATGAGCTTAATAAGAAAATTATTGAGCTACAGGCAA
TTTTACAAAGTGAAAAAAGATTACTTCAAGTAATTAAAACAGATTTAAAGAGAGTTAAGAAAACATATAGTGATGATCGA
CGCGCGATTATTGAAGATCAAATCGAGGAAATTAAAATCGATGTAGAAGTGATGATCCCACAAGAAGATGTCATCGTTAC
TGTAACGAAAGAAGGATATGTGAAACGTACTGGATGGCGCTCACATAATGCCTCAAATGGCAAAGACTTCGGTATGAAAG
AGGGTGACATCTTACTTGAACGATTCGATACGAATACGACAGAGACAGTCCTCTTATTTACGAATAAAGGAAACTATATA
TATCTGCCAGTATACGAAATGCCAGATATTCGTTGGAAAGATTTAGGACAGCACGTTGCTAATATCGTTTCACTCGATCG
GGATGAAACCATCATTTGGGCAACTGTCGTACCGAACTTTGAGGAAGAAAAGCGATTTATCGTATTTGTAACAAAGAACG
GTATGATTAAGAAAACAGAATTAAACCAATATAAAGTACAGCGTTACTCAAGAGCATTCGTTGCTGTAAACTTGAAAAAA
GATGATGAAGTTGTTGATATATTTGCGACAGATGGAACGAGTGATATCGTTCTTGCTACACACGGTGCATATGCACTTAT
TTTCCATGAAGATGAAGTAAGTCCAGTCGGTGTAAGAGCCGCTGGTGTGAAAGCAATTAATTTAAAAGAAGATGACTATG
TCGCTTCTGGTAAACCATTAAATGCTGATAAAGATCAACTTATTCTCGTAACGCAGCGCGGTGCTGTAAAACGCCTAAAA
GCATCAGAAATTGAGAAATCAACGAGGGCGAAGCGAGGTCTTGTTATTTTCAAAGAATTAAAACGTAATCCATACCGCAT
TGTCGGTATTGAAATTGTTCGAGACGATGAACTAGTTTACATGAAGACAGAGAAACATATCGTAGAAGAAATTGATCCGA
AAGCGTATCGAAATAAAGACCGGTATAGTAACGGTAGTTTAGTGCTAGATGTTAATGATACTGGTGAAGTTATTGAAACG
TGGACGAAAAAACGACCGGAATAA

Upstream 100 bases:

>100_bases
CCGCGCCGTAAATGGATTGAGCGCAATGTACAGTTCGGTATGCAAGAAGAAGGAAATATTTTAGAAAATGAAATGATTAT
GGAGACGGAGGTGGAATAAC

Downstream 100 bases:

>100_bases
AAAAAGCATCTTGCCATGAATAATGGCAAGATGCTTTTTTCTAAGCAATTTATTATGTAAATAATAATAATCTTGTTATA
ATAACTGAATGAAATCGTTC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVHDKAFRKSAKTVGNVIGNYHPHGD
SSVYEAMVRLSQTWKVRNVLVEMHGNNGSVDGDPAAAMRYTEARLSPIASELLRDLDKETVEFVSNFDDTSEEPVVLPAA
FPNLLVNGSTGISAGYATEIPPHHLGEVIDATMMRIDKPNSTVDDLLTVMKGPDFPTGGIIQGIDGIKKAYETGKGKIII
RGKAEVETVRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRIVVELKKEANSEGILNYLYKN
TDLQIPYNFNMVAINNRRPTLMTLPKILDAYIGHQKEVVTRRSQYELRKAENRQHIVEGLKKALSILDQVIETIRASKDK
RNAKDNLSAKFGFTEAQAEAIVSLQLYRLTNTDITALQQEADELNKKIIELQAILQSEKRLLQVIKTDLKRVKKTYSDDR
RAIIEDQIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDILLERFDTNTTETVLLFTNKGNYI
YLPVYEMPDIRWKDLGQHVANIVSLDRDETIIWATVVPNFEEEKRFIVFVTKNGMIKKTELNQYKVQRYSRAFVAVNLKK
DDEVVDIFATDGTSDIVLATHGAYALIFHEDEVSPVGVRAAGVKAINLKEDDYVASGKPLNADKDQLILVTQRGAVKRLK
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEIVRDDELVYMKTEKHIVEEIDPKAYRNKDRYSNGSLVLDVNDTGEVIET
WTKKRPE

Sequences:

>Translated_807_residues
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVHDKAFRKSAKTVGNVIGNYHPHGD
SSVYEAMVRLSQTWKVRNVLVEMHGNNGSVDGDPAAAMRYTEARLSPIASELLRDLDKETVEFVSNFDDTSEEPVVLPAA
FPNLLVNGSTGISAGYATEIPPHHLGEVIDATMMRIDKPNSTVDDLLTVMKGPDFPTGGIIQGIDGIKKAYETGKGKIII
RGKAEVETVRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRIVVELKKEANSEGILNYLYKN
TDLQIPYNFNMVAINNRRPTLMTLPKILDAYIGHQKEVVTRRSQYELRKAENRQHIVEGLKKALSILDQVIETIRASKDK
RNAKDNLSAKFGFTEAQAEAIVSLQLYRLTNTDITALQQEADELNKKIIELQAILQSEKRLLQVIKTDLKRVKKTYSDDR
RAIIEDQIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDILLERFDTNTTETVLLFTNKGNYI
YLPVYEMPDIRWKDLGQHVANIVSLDRDETIIWATVVPNFEEEKRFIVFVTKNGMIKKTELNQYKVQRYSRAFVAVNLKK
DDEVVDIFATDGTSDIVLATHGAYALIFHEDEVSPVGVRAAGVKAINLKEDDYVASGKPLNADKDQLILVTQRGAVKRLK
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEIVRDDELVYMKTEKHIVEEIDPKAYRNKDRYSNGSLVLDVNDTGEVIET
WTKKRPE
>Mature_807_residues
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVHDKAFRKSAKTVGNVIGNYHPHGD
SSVYEAMVRLSQTWKVRNVLVEMHGNNGSVDGDPAAAMRYTEARLSPIASELLRDLDKETVEFVSNFDDTSEEPVVLPAA
FPNLLVNGSTGISAGYATEIPPHHLGEVIDATMMRIDKPNSTVDDLLTVMKGPDFPTGGIIQGIDGIKKAYETGKGKIII
RGKAEVETVRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRIVVELKKEANSEGILNYLYKN
TDLQIPYNFNMVAINNRRPTLMTLPKILDAYIGHQKEVVTRRSQYELRKAENRQHIVEGLKKALSILDQVIETIRASKDK
RNAKDNLSAKFGFTEAQAEAIVSLQLYRLTNTDITALQQEADELNKKIIELQAILQSEKRLLQVIKTDLKRVKKTYSDDR
RAIIEDQIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDILLERFDTNTTETVLLFTNKGNYI
YLPVYEMPDIRWKDLGQHVANIVSLDRDETIIWATVVPNFEEEKRFIVFVTKNGMIKKTELNQYKVQRYSRAFVAVNLKK
DDEVVDIFATDGTSDIVLATHGAYALIFHEDEVSPVGVRAAGVKAINLKEDDYVASGKPLNADKDQLILVTQRGAVKRLK
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEIVRDDELVYMKTEKHIVEEIDPKAYRNKDRYSNGSLVLDVNDTGEVIET
WTKKRPE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=29.7142857142857, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI19913408, Length=176, Percent_Identity=29.5454545454545, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1788562, Length=794, Percent_Identity=40.3022670025189, Blast_Score=553, Evalue=1e-158,
Organism=Escherichia coli, GI1789396, Length=750, Percent_Identity=33.2, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI212645845, Length=175, Percent_Identity=29.7142857142857, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=27.1276595744681, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 91509; Mature: 91509

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVHDKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHEECCCCCHHH
FRKSAKTVGNVIGNYHPHGDSSVYEAMVRLSQTWKVRNVLVEMHGNNGSVDGDPAAAMRY
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCHHHHHH
TEARLSPIASELLRDLDKETVEFVSNFDDTSEEPVVLPAAFPNLLVNGSTGISAGYATEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCC
PPHHLGEVIDATMMRIDKPNSTVDDLLTVMKGPDFPTGGIIQGIDGIKKAYETGKGKIII
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
RGKAEVETVRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRI
ECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VVELKKEANSEGILNYLYKNTDLQIPYNFNMVAINNRRPTLMTLPKILDAYIGHQKEVVT
EEEEECCCCCCHHHHHHCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHH
RRSQYELRKAENRQHIVEGLKKALSILDQVIETIRASKDKRNAKDNLSAKFGFTEAQAEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHH
IVSLQLYRLTNTDITALQQEADELNKKIIELQAILQSEKRLLQVIKTDLKRVKKTYSDDR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RAIIEDQIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDILLE
HHHHHHHHHHEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEEE
RFDTNTTETVLLFTNKGNYIYLPVYEMPDIRWKDLGQHVANIVSLDRDETIIWATVVPNF
ECCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
EEEKRFIVFVTKNGMIKKTELNQYKVQRYSRAFVAVNLKKDDEVVDIFATDGTSDIVLAT
CCCCEEEEEEECCCEEEECCCHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCCEEEEE
HGAYALIFHEDEVSPVGVRAAGVKAINLKEDDYVASGKPLNADKDQLILVTQRGAVKRLK
CCEEEEEEECCCCCCCCEEECCEEEEECCCCCEECCCCCCCCCCCCEEEEECCCHHHHHH
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEIVRDDELVYMKTEKHIVEEIDPKAYRNKD
HHHHHHHHHHHCCEEEEHHHCCCCEEEEEEEEEECCCEEEEECHHHHHHHCCCHHHCCCC
RYSNGSLVLDVNDTGEVIETWTKKRPE
CCCCCCEEEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQAEKFHDLPLEDVLGDRFARYSKYIIQDRALPDARDGLKPVQRRILYSMYVEGNVHDKA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHEECCCCCHHH
FRKSAKTVGNVIGNYHPHGDSSVYEAMVRLSQTWKVRNVLVEMHGNNGSVDGDPAAAMRY
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCHHHHHH
TEARLSPIASELLRDLDKETVEFVSNFDDTSEEPVVLPAAFPNLLVNGSTGISAGYATEI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCCC
PPHHLGEVIDATMMRIDKPNSTVDDLLTVMKGPDFPTGGIIQGIDGIKKAYETGKGKIII
CHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEE
RGKAEVETVRGGKQQIVITEIPYEVNKANLVKKMDELRLDKKLDGIAEVRDETDRTGLRI
ECCCHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
VVELKKEANSEGILNYLYKNTDLQIPYNFNMVAINNRRPTLMTLPKILDAYIGHQKEVVT
EEEEECCCCCCHHHHHHCCCCCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCHHHHHH
RRSQYELRKAENRQHIVEGLKKALSILDQVIETIRASKDKRNAKDNLSAKFGFTEAQAEA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHH
IVSLQLYRLTNTDITALQQEADELNKKIIELQAILQSEKRLLQVIKTDLKRVKKTYSDDR
EEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
RAIIEDQIEEIKIDVEVMIPQEDVIVTVTKEGYVKRTGWRSHNASNGKDFGMKEGDILLE
HHHHHHHHHHEEEEEEEEECCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCEEEE
RFDTNTTETVLLFTNKGNYIYLPVYEMPDIRWKDLGQHVANIVSLDRDETIIWATVVPNF
ECCCCCCEEEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCC
EEEKRFIVFVTKNGMIKKTELNQYKVQRYSRAFVAVNLKKDDEVVDIFATDGTSDIVLAT
CCCCEEEEEEECCCEEEECCCHHHHHHHHCEEEEEEEECCCCCEEEEEECCCCCCEEEEE
HGAYALIFHEDEVSPVGVRAAGVKAINLKEDDYVASGKPLNADKDQLILVTQRGAVKRLK
CCEEEEEEECCCCCCCCEEECCEEEEECCCCCEECCCCCCCCCCCCEEEEECCCHHHHHH
ASEIEKSTRAKRGLVIFKELKRNPYRIVGIEIVRDDELVYMKTEKHIVEEIDPKAYRNKD
HHHHHHHHHHHCCEEEEHHHCCCCEEEEEEEEEECCCEEEEECHHHHHHHCCCHHHCCCC
RYSNGSLVLDVNDTGEVIETWTKKRPE
CCCCCCEEEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]