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The map label for this gene is panE [H]

Identifier: 52141568

GI number: 52141568

Start: 3822640

End: 3823530

Strand: Reverse

Name: panE [H]

Synonym: BCZK3679

Alternate gene names: 52141568

Gene position: 3823530-3822640 (Counterclockwise)

Preceding gene: 52141566

Following gene: 52141569

Centisome position: 72.13

GC content: 36.14

Gene sequence:

>891_bases
ATGAAAATGAAAATTGGAGTTGTGGGACCAGGAGCTATCGGTCTATTGTATACATTTTATTTACAAAAAAGTAATCAAGA
TGTTACGTTGTTTACAAGGACAGCTAAGCAGGCTGACGAATTAAATATAACGGGTGTAACTTGTATTAGGGAGGGGAAAC
GTGAAACGGTATTCCCGCAGGTATTCCCAATAGAAAGTATGCCAGACCAGCAGCTAGACTATATATTTATTGCTGTTAAG
CAATATCATATAACTGATATACTACCTTTTGTGCGAGGGAAATCCTCATTAATCTTTTTGCAAAACGGCATGTCACACCT
TCATACTATGCAGAAAATAGAGAATGAAAATGTTGCAGTCGGAATTGTGGAGCATGGTGCAAAAAAAGAAGAAAGACATA
CCGTTTATCATACAGGGATAGGCGTAACGAAGTTTGGAATCGTGCACGGTCGGTCTATACATTTTGAAAAAATATTTAAT
TGCTTTCCCTTCCCTCATTTTCCGATTCGAATAGAAGATAATTGGAAGGATGTTATGCACAAAAAATTAGTAGTTAATGT
ATGCATCAACCCATTGACGGCATTATTACAAGTAAAGAACGGAGATTTAATTACGAATCCGTTTTTTTATCAGATGATGG
AGCAAGTATTCCACGAAGTCGTTTTTCTCGTTAAAGAAGAAAAAGAAATGGTATGGGAAATGGTACGTCATGTATGTGAA
AGAACGTCTCATAATACATCATCTATGCTGGCAGATGTAAGGGCGAATAGACAAACAGAAATTGGTGCAATTGTTGGATA
TGTATTAGAAGAAGCTAAGAAACAGCAACGATCTGTTCCGACACTTCAATTTTTGTTTGATGCAATAAGAGGATTAGAAG
TAAAAGTATAA

Upstream 100 bases:

>100_bases
TCATCTTTAATTAATTATGATTCCACACGAATCGAGTGTTCGCGGAATAAAAGGGGAGGGGAAAAGGGACTTATGTATAG
TATGCAAATGAGTTCCTTGT

Downstream 100 bases:

>100_bases
GTGTAATTCTTTGCTTTTACGTGAAACATTGACTACAATGTGGATTGGTGAGAGAACAGGATACGAAAGGAAGAATTATA
TGGAGATAAAAGAGATCTCT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKMKIGVVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQADELNITGVTCIREGKRETVFPQVFPIESMPDQQLDYIFIAVK
QYHITDILPFVRGKSSLIFLQNGMSHLHTMQKIENENVAVGIVEHGAKKEERHTVYHTGIGVTKFGIVHGRSIHFEKIFN
CFPFPHFPIRIEDNWKDVMHKKLVVNVCINPLTALLQVKNGDLITNPFFYQMMEQVFHEVVFLVKEEKEMVWEMVRHVCE
RTSHNTSSMLADVRANRQTEIGAIVGYVLEEAKKQQRSVPTLQFLFDAIRGLEVKV

Sequences:

>Translated_296_residues
MKMKIGVVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQADELNITGVTCIREGKRETVFPQVFPIESMPDQQLDYIFIAVK
QYHITDILPFVRGKSSLIFLQNGMSHLHTMQKIENENVAVGIVEHGAKKEERHTVYHTGIGVTKFGIVHGRSIHFEKIFN
CFPFPHFPIRIEDNWKDVMHKKLVVNVCINPLTALLQVKNGDLITNPFFYQMMEQVFHEVVFLVKEEKEMVWEMVRHVCE
RTSHNTSSMLADVRANRQTEIGAIVGYVLEEAKKQQRSVPTLQFLFDAIRGLEVKV
>Mature_296_residues
MKMKIGVVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQADELNITGVTCIREGKRETVFPQVFPIESMPDQQLDYIFIAVK
QYHITDILPFVRGKSSLIFLQNGMSHLHTMQKIENENVAVGIVEHGAKKEERHTVYHTGIGVTKFGIVHGRSIHFEKIFN
CFPFPHFPIRIEDNWKDVMHKKLVVNVCINPLTALLQVKNGDLITNPFFYQMMEQVFHEVVFLVKEEKEMVWEMVRHVCE
RTSHNTSSMLADVRANRQTEIGAIVGYVLEEAKKQQRSVPTLQFLFDAIRGLEVKV

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=299, Percent_Identity=25.752508361204, Blast_Score=98, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34005; Mature: 34005

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKIGVVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQADELNITGVTCIREGKRETVFPQ
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCE
VFPIESMPDQQLDYIFIAVKQYHITDILPFVRGKSSLIFLQNGMSHLHTMQKIENENVAV
EECCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCEEE
GIVEHGAKKEERHTVYHTGIGVTKFGIVHGRSIHFEKIFNCFPFPHFPIRIEDNWKDVMH
EEECCCCCCCCCCEEEECCCCEEEEEEEECCEECHHHHHHHCCCCCCEEEECCCHHHHHH
KKLVVNVCINPLTALLQVKNGDLITNPFFYQMMEQVFHEVVFLVKEEKEMVWEMVRHVCE
HHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTSHNTSSMLADVRANRQTEIGAIVGYVLEEAKKQQRSVPTLQFLFDAIRGLEVKV
HCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEECC
>Mature Secondary Structure
MKMKIGVVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQADELNITGVTCIREGKRETVFPQ
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCE
VFPIESMPDQQLDYIFIAVKQYHITDILPFVRGKSSLIFLQNGMSHLHTMQKIENENVAV
EECCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCEEE
GIVEHGAKKEERHTVYHTGIGVTKFGIVHGRSIHFEKIFNCFPFPHFPIRIEDNWKDVMH
EEECCCCCCCCCCEEEECCCCEEEEEEEECCEECHHHHHHHCCCCCCEEEECCCHHHHHH
KKLVVNVCINPLTALLQVKNGDLITNPFFYQMMEQVFHEVVFLVKEEKEMVWEMVRHVCE
HHHHHHHHHHHHHHHHEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTSHNTSSMLADVRANRQTEIGAIVGYVLEEAKKQQRSVPTLQFLFDAIRGLEVKV
HCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]