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The map label for this gene is metC [H]

Identifier: 52141243

GI number: 52141243

Start: 4116671

End: 4117783

Strand: Direct

Name: metC [H]

Synonym: BCZK4007

Alternate gene names: 52141243

Gene position: 4116671-4117783 (Clockwise)

Preceding gene: 52141248

Following gene: 52141241

Centisome position: 77.66

GC content: 39.26

Gene sequence:

>1113_bases
ATGTCAACTATCGAAACAAAACTAGCGCAAATCGGAAACCGGAGTGAAACTACAACAGGAACTGTTAATCCGCCTGTTTA
CTTTTCAACTGCTTATCGTCACGAAGGAATTGGTAAATCTACTGGATTTGACTATTCACGAACTGGAAATCCAACTCGCG
GCCTATTAGAACAGGCAATCGCAGACTTAGAATACGGCGAACAAGGTTATGCCTGTAGTTCAGGGATGGCAGCCGTTCTT
CTTGTCCTTTCCCTATTCCGCTCCGGAGACGAACTTATTGTATCCGAAGATTTATACGGGGGCACTTATCGATTATTTTC
TGAGCACGAAAAAAAGTGGAATGTTCGATGTAGATACGTAAATACACAATCTATTAAACAAATTGAGCAAGCTATCACAA
CTGAAACGAAAGCTATTTTCATAGAAACCCCGACAAATCCATTAATGCAAGTTACTGATATTGCCGCTGTCGCAACTGTA
GCAAAAAGACACGGACTACTTCTTATTGTAGACAATACATTCTATACGCCTTATATACAGCAGCCATTAACAGAAGGTGC
TGACATTGTACTTCATAGCGCAACAAAATATTTAGGAGGACATAACGATGTACTAAGCGGACTTGTCGTTGCAAAAGGAA
AGGAACTTTGTGAGGAAATCGCCCATTATCATAATGCATCAGGTGCGGTCTTAAGTCCATTTGACTCATGGCTATTAATC
CGTGGTATGAAAACGTTAGCGCTTCGCATGAGACAACATGAAGAAAATGCAAAAGCAGTTGTTGCTTATTTAAATGATGA
GGACGGGGTGACAGATGTATTTTATCCTGGAAGAGGAGGCATGATCTCATTTCGTCTTAAAGATGAAGAATGGATTAATC
CATTCTTACAATCTTTATCCTTAATTACATTCGCCGAAAGTCTTGGTGGTGTTGAAAGTTTAATGACATATCCAGCAACA
CAAACACACGCTGATATTCCTGAAGAAATCAGAACAGCAAACGGTGTATGTAATCGTCTTCTTCGATTTTCTGTTGGCAT
TGAAAATAGTAACGATTTAATTCAAGACTTACAGCAAGCCATTAAACTTGTAAAAGAAGGTGTAAGAATATGA

Upstream 100 bases:

>100_bases
TGAGAAGAAGACTCTATTCAAACCGAAAGCCTTCTTCTTAGAAGGCTTTTTTTATTTTATATTCAACTACTGGTTCAATT
TAAAAAGGAGGAATTTTCAC

Downstream 100 bases:

>100_bases
GTTATTCTATAGATACACTCTTACTACACAACCAATATAAACATGATCCACAAACAGGAGCGGTTAACGTTCCCATCTAT
AACACATCAACATTCCACCA

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CGS; O-acetylhomoserine (thiol)-lyase; O-acetylhomoserine sulfhydrylase; OAH sulfhydrylase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSTIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMAAVL
LVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATV
AKRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLI
RGMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGMISFRLKDEEWINPFLQSLSLITFAESLGGVESLMTYPAT
QTHADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAIKLVKEGVRI

Sequences:

>Translated_370_residues
MSTIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMAAVL
LVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATV
AKRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLI
RGMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGMISFRLKDEEWINPFLQSLSLITFAESLGGVESLMTYPAT
QTHADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAIKLVKEGVRI
>Mature_369_residues
STIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAIADLEYGEQGYACSSGMAAVLL
VLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYVNTQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVA
KRHGLLLIVDNTFYTPYIQQPLTEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLIR
GMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGMISFRLKDEEWINPFLQSLSLITFAESLGGVESLMTYPATQ
THADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQAIKLVKEGVRI

Specific function: Catalyzes the transformation of O-succinylhomoserine into cystathionine, as well as O-acetylhomoserine and sulfide into homocysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=376, Percent_Identity=41.2234042553192, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI299473759, Length=376, Percent_Identity=38.031914893617, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI25453487, Length=375, Percent_Identity=35.4666666666667, Blast_Score=209, Evalue=5e-54,
Organism=Escherichia coli, GI1790375, Length=366, Percent_Identity=41.2568306010929, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1789383, Length=391, Percent_Identity=26.8542199488491, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17538055, Length=362, Percent_Identity=41.9889502762431, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17560056, Length=384, Percent_Identity=40.625, Blast_Score=278, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=36.7847411444142, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6319307, Length=368, Percent_Identity=42.6630434782609, Blast_Score=284, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6321254, Length=400, Percent_Identity=31.75, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6323333, Length=416, Percent_Identity=31.7307692307692, Blast_Score=172, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=277, Percent_Identity=33.2129963898917, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=28.3887468030691, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI19922554, Length=368, Percent_Identity=39.6739130434783, Blast_Score=283, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =2.5.1.48; =2.5.1.49 [H]

Molecular weight: Translated: 40892; Mature: 40761

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00868 CYS_MET_METAB_PP ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAI
CCHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
ADLEYGEQGYACSSGMAAVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYV
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEE
NTQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQ
CHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHH
QPLTEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLI
HHHCCCCCEEEEHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEECCHHHHHHH
RGMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGMISFRLKDEEWINPFLQSLS
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHH
LITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQA
HHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IKLVKEGVRI
HHHHHHCCCC
>Mature Secondary Structure 
STIETKLAQIGNRSETTTGTVNPPVYFSTAYRHEGIGKSTGFDYSRTGNPTRGLLEQAI
CHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHCCCCCCCCCCCCCCCCCHHHHHHHHH
ADLEYGEQGYACSSGMAAVLLVLSLFRSGDELIVSEDLYGGTYRLFSEHEKKWNVRCRYV
HHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEE
NTQSIKQIEQAITTETKAIFIETPTNPLMQVTDIAAVATVAKRHGLLLIVDNTFYTPYIQ
CHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHH
QPLTEGADIVLHSATKYLGGHNDVLSGLVVAKGKELCEEIAHYHNASGAVLSPFDSWLLI
HHHCCCCCEEEEHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCEECCHHHHHHH
RGMKTLALRMRQHEENAKAVVAYLNDEDGVTDVFYPGRGGMISFRLKDEEWINPFLQSLS
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCEEEEEECCHHHHHHHHHHHH
LITFAESLGGVESLMTYPATQTHADIPEEIRTANGVCNRLLRFSVGIENSNDLIQDLQQA
HHHHHHHHCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
IKLVKEGVRI
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]