Click here to switch to the map view.

The map label for this gene is vpr [H]

Identifier: 52141149

GI number: 52141149

Start: 4206717

End: 4209470

Strand: Direct

Name: vpr [H]

Synonym: BCZK4101

Alternate gene names: 52141149

Gene position: 4206717-4209470 (Clockwise)

Preceding gene: 52141152

Following gene: 52141148

Centisome position: 79.36

GC content: 37.18

Gene sequence:

>2754_bases
ATGAAAAAAACTACATCTACACTATTAAGTATGGCGCTCGTCTTTTCCAGTTTTGGAGCTTTAAGCGCACATGCTGAATC
GCTGCAAAAGGAGAAACAGTTTAGTCCACAGTTAAAAGCGAACATTGAACAATGGGGAGAAAACAAAATTGCGCAAAATG
TTGAAACAAAAACATCAAAAGAAATTTCTGTCATTGTAGAATTGCAACATGCTCCACTCGCTTCACAAAGTAACATTCAG
CATGCTCCAGATTTACAAAATAATAATGCACAGTCTTATCATACCGAGCTTAAAAAAGCACAAGAAGATACGACTAAGAA
AATAAAAGAAAAAGCACCTGGTGCAAAAATTAAAGAAGTGTATAATACGTTATTTTCTGGATTCTCTATTTCAGTTCCTG
GAGATCAAATTACCGCTCTTGCTTCTTTACCCGAAGTAAAAGCAGTCTACCCGAACTTAACATATAAATTACATGAAACA
TCAAAAAGCACTACTAATGAAGAAGCACCAAATATCGGCGGACCGACAATTGGTGCAACTGAAGCATGGAATTTAAAAGA
CCCATCTGGCAAACCGCTTGATGGAAAAGGTATGAAAGTAGCGATTATCGACTCTGGTGTAGACTATACACATCCTGACT
TAAAAGCAAATTATATCGGTGGATATGACACAGTTGATGAAGATAACGATCCAATGGATGGTAACGTACATGGTACCCAT
GTAGCTGGAATTATTGCTGGTAACGGAAAAATTAAAGGCGTTGCTCCAAATGCTTCTATTCTAGCCTATCGTGTAATGAA
TGATGGTGGAACTGGTACAACAGAAGATATTATTCAAGGTATTGAACGAGCAATCCAAGACGGTGCTGACGTTTTAAATT
TATCTCTTGGACAAAGCTTAAATACACCTGATCAGCCTGTAACATTAACATTAGAACGTGCAGCAAAACTTGGGGTTACT
GCAGTTGTTTCAAATGGAAATGATGGCCCACATCCTTGGTCTGTTGATGCACCTGGAAATGCAAGCAGCGTTATATCAGT
TGGAGCATCTACTGTTTCTATCCCGTTTCCAACGTTCCAAGTAGCTGGTTCCAGCAAAACATATCAAGGGTTACCGTTAT
CAAAGTCCGATTTCCCAATAGGAAATGATTCCCCTCTTGTATACGTTGGCTATGGTAATCCAAGTGATTATGCAAAACAA
GATGTGAAAGGGAAATTTGCACTTGTTTTACAAGGTACTTCTAGTACGTTAGTAAAAGCAGAACAAGCGAAACAAGCTGG
TGCAGTTGGTGTACTATTCATTTCTACAGAAAAAGAAATCAATATTATGCCAGAATATTTTATGCGTGAAAATCTAGCCC
TTCCAGTTATGCAATTATCAAATGTACACGGTGAAGAGTTGAAAAACTTAATTACAAAGCGTAAGAAAAATATAAAAATT
GGCCAACCAAATCCAACCGAATTGATTGCTAACTTCAGTTCCAGAGGTCCGTCACAAGGAAGTTGGCTTATAAAACCAGA
TATAATTGCACCTGGCGTACAAATTATGAGTACAGTACCGAGAGGCGGCTATGAATCTCATAATGGTACAAGTATGGCTG
CTCCACAAGTAGCTGGAGCGGTTGCCCTCTTGCGTCAAATGCATCCTGATTGGACGACAGAGCAATTAAAAGCATCCCTT
GCCAATACCGCAAAAATTTTAAAAGATGTGAATGAAAATACATATCCTATTATGACACAAGGATCTGGTTTAATTAACAT
CCCGAAAGCAGCTCAAACAGATGTATTAGTCAAACCTAACAATGTGAGCTTCGGTCTTATTAAGCCAAACAGTGGTAAAG
TAAAACTGACGCAAAATATTACGTTACAAAATCTATCTAGTAAAAAGAAAAGTTTTTCAACTCGTGTGGAATTGCTAGAT
ACAAACACAAAAACAAAAGTAAAAACTTCTGTACCTTCATCGATTAGCATACAGCCGAATAATAGTACCGAAAAACCATT
TACTATCACTGTCGATAGTTCGCTACCCCAAGGTGTCTATACTGGAAATGTGTATATAAAAGAACAAGGTAAGAAGGAAG
AAACTCGCATTCCATTTACATTTAGTATCGATCCTAAAGATTACAAACGTATAGATGGACTCGAAATTATTAATTCTACA
TTTAGTCCAAATGGTGACCAAATATTAGACGATAATCTCATCAACTACTATTTAGTTGCACCTGTAGATGATGTAACATT
GCATGCAAATTTAGTTACAAAAGAACATGTAACGTACCAAGGGATTATCCATCAAGCTAAAAATGAAACAGCTGGATACA
AACCTTTCAAATGGAATGGTACAAAAGCAGATGGTACTCCGTTAGCTGACGGTCTATACCAAATCGAAGCAGTTGCCTCT
AATTCTGGTGGGGAAACAAAACAAACAGCTGCTGTATTTCTTGATAGAACTGCACCTAAGTTAACATACGAAATTGACCA
AGAAAACCTTGTAATCACAGGAAAAGTGGATGATATCTTACTAGATTGGATGACAGAATCTGGTTGGGTAGCACCTGGAA
TTCCAGTGAGACTACAGTATGAAATCAACGGAAATGGTGTATGGGAAAGTGCATTCCTAAATCCTTGGGAGAAAAATTAC
GGCATTTATTTAGATCGTACTCAATTACAAGAAGTTAAAAATACAATTCACATTGTAGCAACAGATGCAGCTGGAAATAC
ATCTAATTTAAATGTTGATTTAGATGTGAAATAA

Upstream 100 bases:

>100_bases
GTCGAAAATATAATTTAGCTAACATCCGATTATGTAATTCGAGATAAATTTGTAAGATTACTTTTCGGAATATTAGCACT
TTTTATCAGGGGGAGTTTCA

Downstream 100 bases:

>100_bases
AGTGAAACTTTAATCAGTGGGGGGTTCTTCATCCCCCACTGATTATTAGTTGAACCAATCGGGCTTTTATGGGCAGCCCG
ACCCCCACCTAACTTCTTTA

Product: minor extracellular protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 917; Mature: 917

Protein sequence:

>917_residues
MKKTTSTLLSMALVFSSFGALSAHAESLQKEKQFSPQLKANIEQWGENKIAQNVETKTSKEISVIVELQHAPLASQSNIQ
HAPDLQNNNAQSYHTELKKAQEDTTKKIKEKAPGAKIKEVYNTLFSGFSISVPGDQITALASLPEVKAVYPNLTYKLHET
SKSTTNEEAPNIGGPTIGATEAWNLKDPSGKPLDGKGMKVAIIDSGVDYTHPDLKANYIGGYDTVDEDNDPMDGNVHGTH
VAGIIAGNGKIKGVAPNASILAYRVMNDGGTGTTEDIIQGIERAIQDGADVLNLSLGQSLNTPDQPVTLTLERAAKLGVT
AVVSNGNDGPHPWSVDAPGNASSVISVGASTVSIPFPTFQVAGSSKTYQGLPLSKSDFPIGNDSPLVYVGYGNPSDYAKQ
DVKGKFALVLQGTSSTLVKAEQAKQAGAVGVLFISTEKEINIMPEYFMRENLALPVMQLSNVHGEELKNLITKRKKNIKI
GQPNPTELIANFSSRGPSQGSWLIKPDIIAPGVQIMSTVPRGGYESHNGTSMAAPQVAGAVALLRQMHPDWTTEQLKASL
ANTAKILKDVNENTYPIMTQGSGLINIPKAAQTDVLVKPNNVSFGLIKPNSGKVKLTQNITLQNLSSKKKSFSTRVELLD
TNTKTKVKTSVPSSISIQPNNSTEKPFTITVDSSLPQGVYTGNVYIKEQGKKEETRIPFTFSIDPKDYKRIDGLEIINST
FSPNGDQILDDNLINYYLVAPVDDVTLHANLVTKEHVTYQGIIHQAKNETAGYKPFKWNGTKADGTPLADGLYQIEAVAS
NSGGETKQTAAVFLDRTAPKLTYEIDQENLVITGKVDDILLDWMTESGWVAPGIPVRLQYEINGNGVWESAFLNPWEKNY
GIYLDRTQLQEVKNTIHIVATDAAGNTSNLNVDLDVK

Sequences:

>Translated_917_residues
MKKTTSTLLSMALVFSSFGALSAHAESLQKEKQFSPQLKANIEQWGENKIAQNVETKTSKEISVIVELQHAPLASQSNIQ
HAPDLQNNNAQSYHTELKKAQEDTTKKIKEKAPGAKIKEVYNTLFSGFSISVPGDQITALASLPEVKAVYPNLTYKLHET
SKSTTNEEAPNIGGPTIGATEAWNLKDPSGKPLDGKGMKVAIIDSGVDYTHPDLKANYIGGYDTVDEDNDPMDGNVHGTH
VAGIIAGNGKIKGVAPNASILAYRVMNDGGTGTTEDIIQGIERAIQDGADVLNLSLGQSLNTPDQPVTLTLERAAKLGVT
AVVSNGNDGPHPWSVDAPGNASSVISVGASTVSIPFPTFQVAGSSKTYQGLPLSKSDFPIGNDSPLVYVGYGNPSDYAKQ
DVKGKFALVLQGTSSTLVKAEQAKQAGAVGVLFISTEKEINIMPEYFMRENLALPVMQLSNVHGEELKNLITKRKKNIKI
GQPNPTELIANFSSRGPSQGSWLIKPDIIAPGVQIMSTVPRGGYESHNGTSMAAPQVAGAVALLRQMHPDWTTEQLKASL
ANTAKILKDVNENTYPIMTQGSGLINIPKAAQTDVLVKPNNVSFGLIKPNSGKVKLTQNITLQNLSSKKKSFSTRVELLD
TNTKTKVKTSVPSSISIQPNNSTEKPFTITVDSSLPQGVYTGNVYIKEQGKKEETRIPFTFSIDPKDYKRIDGLEIINST
FSPNGDQILDDNLINYYLVAPVDDVTLHANLVTKEHVTYQGIIHQAKNETAGYKPFKWNGTKADGTPLADGLYQIEAVAS
NSGGETKQTAAVFLDRTAPKLTYEIDQENLVITGKVDDILLDWMTESGWVAPGIPVRLQYEINGNGVWESAFLNPWEKNY
GIYLDRTQLQEVKNTIHIVATDAAGNTSNLNVDLDVK
>Mature_917_residues
MKKTTSTLLSMALVFSSFGALSAHAESLQKEKQFSPQLKANIEQWGENKIAQNVETKTSKEISVIVELQHAPLASQSNIQ
HAPDLQNNNAQSYHTELKKAQEDTTKKIKEKAPGAKIKEVYNTLFSGFSISVPGDQITALASLPEVKAVYPNLTYKLHET
SKSTTNEEAPNIGGPTIGATEAWNLKDPSGKPLDGKGMKVAIIDSGVDYTHPDLKANYIGGYDTVDEDNDPMDGNVHGTH
VAGIIAGNGKIKGVAPNASILAYRVMNDGGTGTTEDIIQGIERAIQDGADVLNLSLGQSLNTPDQPVTLTLERAAKLGVT
AVVSNGNDGPHPWSVDAPGNASSVISVGASTVSIPFPTFQVAGSSKTYQGLPLSKSDFPIGNDSPLVYVGYGNPSDYAKQ
DVKGKFALVLQGTSSTLVKAEQAKQAGAVGVLFISTEKEINIMPEYFMRENLALPVMQLSNVHGEELKNLITKRKKNIKI
GQPNPTELIANFSSRGPSQGSWLIKPDIIAPGVQIMSTVPRGGYESHNGTSMAAPQVAGAVALLRQMHPDWTTEQLKASL
ANTAKILKDVNENTYPIMTQGSGLINIPKAAQTDVLVKPNNVSFGLIKPNSGKVKLTQNITLQNLSSKKKSFSTRVELLD
TNTKTKVKTSVPSSISIQPNNSTEKPFTITVDSSLPQGVYTGNVYIKEQGKKEETRIPFTFSIDPKDYKRIDGLEIINST
FSPNGDQILDDNLINYYLVAPVDDVTLHANLVTKEHVTYQGIIHQAKNETAGYKPFKWNGTKADGTPLADGLYQIEAVAS
NSGGETKQTAAVFLDRTAPKLTYEIDQENLVITGKVDDILLDWMTESGWVAPGIPVRLQYEINGNGVWESAFLNPWEKNY
GIYLDRTQLQEVKNTIHIVATDAAGNTSNLNVDLDVK

Specific function: Not required for growth or sporulation [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=155, Percent_Identity=32.258064516129, Blast_Score=70, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71983555, Length=213, Percent_Identity=32.3943661971831, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25141268, Length=213, Percent_Identity=32.3943661971831, Blast_Score=70, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320775, Length=171, Percent_Identity=34.5029239766082, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324576, Length=251, Percent_Identity=29.4820717131474, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319893, Length=168, Percent_Identity=30.3571428571429, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550681, Length=233, Percent_Identity=30.9012875536481, Blast_Score=81, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR010259
- InterPro:   IPR003137 [H]

Pfam domain/function: PF05922 Inhibitor_I9; PF02225 PA; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 99036; Mature: 99036

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER ; PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTTSTLLSMALVFSSFGALSAHAESLQKEKQFSPQLKANIEQWGENKIAQNVETKTSK
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCCCCC
EISVIVELQHAPLASQSNIQHAPDLQNNNAQSYHTELKKAQEDTTKKIKEKAPGAKIKEV
EEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YNTLFSGFSISVPGDQITALASLPEVKAVYPNLTYKLHETSKSTTNEEAPNIGGPTIGAT
HHHHHCCCEEECCCHHEEHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
EAWNLKDPSGKPLDGKGMKVAIIDSGVDYTHPDLKANYIGGYDTVDEDNDPMDGNVHGTH
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEE
VAGIIAGNGKIKGVAPNASILAYRVMNDGGTGTTEDIIQGIERAIQDGADVLNLSLGQSL
EEEEEECCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCC
NTPDQPVTLTLERAAKLGVTAVVSNGNDGPHPWSVDAPGNASSVISVGASTVSIPFPTFQ
CCCCCCEEEEEEHHHHCCEEEEEECCCCCCCCEECCCCCCCCCEEEECCCEEEECCCCEE
VAGSSKTYQGLPLSKSDFPIGNDSPLVYVGYGNPSDYAKQDVKGKFALVLQGTSSTLVKA
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEEEEECCCCHHHHH
EQAKQAGAVGVLFISTEKEINIMPEYFMRENLALPVMQLSNVHGEELKNLITKRKKNIKI
HHHHHCCCEEEEEEECCCCCCCCCHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCC
GQPNPTELIANFSSRGPSQGSWLIKPDIIAPGVQIMSTVPRGGYESHNGTSMAAPQVAGA
CCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHH
VALLRQMHPDWTTEQLKASLANTAKILKDVNENTYPIMTQGSGLINIPKAAQTDVLVKPN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCEEECCC
NVSFGLIKPNSGKVKLTQNITLQNLSSKKKSFSTRVELLDTNTKTKVKTSVPSSISIQPN
CCEEEEEECCCCCEEEEECCEEHHHHHHHHHHCEEEEEEECCCCEEEEECCCCEEEECCC
NSTEKPFTITVDSSLPQGVYTGNVYIKEQGKKEETRIPFTFSIDPKDYKRIDGLEIINST
CCCCCCEEEEECCCCCCCEEECEEEEEECCCCCCCCCCEEEEECCHHHHHCCCHHHHHCC
FSPNGDQILDDNLINYYLVAPVDDVTLHANLVTKEHVTYQGIIHQAKNETAGYKPFKWNG
CCCCCCEEECCCCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEECCC
TKADGTPLADGLYQIEAVASNSGGETKQTAAVFLDRTAPKLTYEIDQENLVITGKVDDIL
CCCCCCCCCCCCEEEEEEECCCCCCCHHEEEEEEECCCCCEEEEECCCCEEEECCHHHHH
LDWMTESGWVAPGIPVRLQYEINGNGVWESAFLNPWEKNYGIYLDRTQLQEVKNTIHIVA
HHHHCCCCCCCCCCCEEEEEEECCCCEEHHHHCCCCCCCCCEEEEHHHHHHHCCEEEEEE
TDAAGNTSNLNVDLDVK
ECCCCCCCCEEEEEEEC
>Mature Secondary Structure
MKKTTSTLLSMALVFSSFGALSAHAESLQKEKQFSPQLKANIEQWGENKIAQNVETKTSK
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCCCCC
EISVIVELQHAPLASQSNIQHAPDLQNNNAQSYHTELKKAQEDTTKKIKEKAPGAKIKEV
EEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YNTLFSGFSISVPGDQITALASLPEVKAVYPNLTYKLHETSKSTTNEEAPNIGGPTIGAT
HHHHHCCCEEECCCHHEEHHHCCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
EAWNLKDPSGKPLDGKGMKVAIIDSGVDYTHPDLKANYIGGYDTVDEDNDPMDGNVHGTH
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEE
VAGIIAGNGKIKGVAPNASILAYRVMNDGGTGTTEDIIQGIERAIQDGADVLNLSLGQSL
EEEEEECCCEEEEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCC
NTPDQPVTLTLERAAKLGVTAVVSNGNDGPHPWSVDAPGNASSVISVGASTVSIPFPTFQ
CCCCCCEEEEEEHHHHCCEEEEEECCCCCCCCEECCCCCCCCCEEEECCCEEEECCCCEE
VAGSSKTYQGLPLSKSDFPIGNDSPLVYVGYGNPSDYAKQDVKGKFALVLQGTSSTLVKA
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCEEEEEEECCCCHHHHH
EQAKQAGAVGVLFISTEKEINIMPEYFMRENLALPVMQLSNVHGEELKNLITKRKKNIKI
HHHHHCCCEEEEEEECCCCCCCCCHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCC
GQPNPTELIANFSSRGPSQGSWLIKPDIIAPGVQIMSTVPRGGYESHNGTSMAAPQVAGA
CCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHH
VALLRQMHPDWTTEQLKASLANTAKILKDVNENTYPIMTQGSGLINIPKAAQTDVLVKPN
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCEEECCCCCCCCEEECCC
NVSFGLIKPNSGKVKLTQNITLQNLSSKKKSFSTRVELLDTNTKTKVKTSVPSSISIQPN
CCEEEEEECCCCCEEEEECCEEHHHHHHHHHHCEEEEEEECCCCEEEEECCCCEEEECCC
NSTEKPFTITVDSSLPQGVYTGNVYIKEQGKKEETRIPFTFSIDPKDYKRIDGLEIINST
CCCCCCEEEEECCCCCCCEEECEEEEEECCCCCCCCCCEEEEECCHHHHHCCCHHHHHCC
FSPNGDQILDDNLINYYLVAPVDDVTLHANLVTKEHVTYQGIIHQAKNETAGYKPFKWNG
CCCCCCEEECCCCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHCCCCCCCCCEECCC
TKADGTPLADGLYQIEAVASNSGGETKQTAAVFLDRTAPKLTYEIDQENLVITGKVDDIL
CCCCCCCCCCCCEEEEEEECCCCCCCHHEEEEEEECCCCCEEEEECCCCEEEECCHHHHH
LDWMTESGWVAPGIPVRLQYEINGNGVWESAFLNPWEKNYGIYLDRTQLQEVKNTIHIVA
HHHHCCCCCCCCCCCEEEEEEECCCCEEHHHHCCCCCCCCCEEEEHHHHHHHCCEEEEEE
TDAAGNTSNLNVDLDVK
ECCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1938892; 7934828; 9384377; 10658653 [H]