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The map label for this gene is metC [H]

Identifier: 52141134

GI number: 52141134

Start: 4222791

End: 4223924

Strand: Reverse

Name: metC [H]

Synonym: BCZK4116

Alternate gene names: 52141134

Gene position: 4223924-4222791 (Counterclockwise)

Preceding gene: 52141133

Following gene: 52141136

Centisome position: 79.68

GC content: 36.86

Gene sequence:

>1134_bases
ATGAGAGCAAAGACAAAGTTAATTCATGGTATTCGCATAGGAGAACCTTCAACTGGATCTGTAAATGTACCGATTTATCA
AACGAGTACGTACAAACAAGAAGCAGTTGGTAAGCATCAAGGATATGAATATTCACGTACAGGAAACCCAACACGTGCAG
CTTTAGAAGAAATGATTGCTGTATTAGAAAACGGTCATGCTGGTTTTGCATTTGGCTCAGGAATGGCGGCTATTACAGCT
ACGATTATGTTGTTCTCAAAAGGTGACCACGTTATTTTAACAGATGATGTGTATGGTGGAACGTACCGCGTGATTACGAA
AGTATTAAACCGCTTCGGTATTGAGCATACATTTGTAGATACAACAAACTTAGAAGAAGTTGAAGAAGCGATTCGTCCAA
ATACGAAAGCGATTTATGTAGAAACACCAACGAATCCACTACTAAAAATTACTGATATTAAAAAAATATCTACTCTTGCT
AAAGAGAAAGATTTATTAACAATTATTGATAACACATTCATGACGCCATATTGGCAGTCGCCGATTTCTTTAGGGGCAGA
TATTGTACTTCATAGTGCAACAAAATATTTAGGAGGTCATAGTGACGTAGTTGCAGGTTTAGTAGTTGTAAATAGCCCGC
AATTAGCAGAAGACCTTCACTTTGTACAAAACTCAACAGGAGGCATTCTTGGCCCGCAAGATAGCTTCTTACTACTTCGT
GGTTTAAAAACATTAGGAATTCGAATGGAAGAGCATGAAACGAATTCACGCGCAATTGCTGAGTTTTTAAATAATCATCC
AAAAGTAAATAAAGTATATTACCCAGGTCTTGCATCACATCAAAACCATGAATTAGCAGCAGAACAAGCAAATGGATTTG
GTGCGATTATCTCATTTGATGTAGATAGCGAAGAAACATTAAATAAAGTACTTGAGAGATTACAATACTTTACACTGGCT
GAAAGTTTAGGAGCAGTAGAAAGTTTAATTTCTATCCCATCTCAAATGACACATGCATCAATCCCAGCAGATCGTCGCAA
AGAACTAGGAATTACAGATACATTAATTCGAATTTCTGTCGGTATTGAAGACGGAGAAGATTTAATTGAAGATTTAGCAC
AAGCGTTAGCATAG

Upstream 100 bases:

>100_bases
AGCAGAGAAAGCGGCGCCAGGTACAAATATTGTAACGATTTTTCCTGATAGTAGTGAGCGCTATTTAAGTAAAGACATAT
ACAAAGGATGGGAATAAAAA

Downstream 100 bases:

>100_bases
TAAAAATGCACTGCTAGTATAGGCAGTGCATTTTTATCACATTTTTTGTGAAATATTTCACAAAATAGACAAACACAAAT
GAAATAAATTCATGTATATT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVDTTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLA
KEKDLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELAAEQANGFGAIISFDVDSEETLNKVLERLQYFTLA
ESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISVGIEDGEDLIEDLAQALA

Sequences:

>Translated_377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVDTTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLA
KEKDLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELAAEQANGFGAIISFDVDSEETLNKVLERLQYFTLA
ESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISVGIEDGEDLIEDLAQALA
>Mature_377_residues
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIAVLENGHAGFAFGSGMAAITA
TIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVDTTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLA
KEKDLLTIIDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELAAEQANGFGAIISFDVDSEETLNKVLERLQYFTLA
ESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISVGIEDGEDLIEDLAQALA

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=355, Percent_Identity=49.5774647887324, Blast_Score=338, Evalue=5e-93,
Organism=Homo sapiens, GI299473759, Length=355, Percent_Identity=45.3521126760563, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI25453487, Length=354, Percent_Identity=44.3502824858757, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1790375, Length=356, Percent_Identity=46.0674157303371, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=30.3571428571429, Blast_Score=182, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17560056, Length=369, Percent_Identity=48.2384823848238, Blast_Score=343, Evalue=6e-95,
Organism=Caenorhabditis elegans, GI17538055, Length=375, Percent_Identity=48, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI71980708, Length=367, Percent_Identity=42.7792915531335, Blast_Score=278, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6319307, Length=367, Percent_Identity=44.9591280653951, Blast_Score=311, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6321254, Length=383, Percent_Identity=35.7702349869452, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6323333, Length=419, Percent_Identity=35.799522673031, Blast_Score=192, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6321170, Length=315, Percent_Identity=31.1111111111111, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321904, Length=343, Percent_Identity=33.8192419825073, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6322970, Length=309, Percent_Identity=26.8608414239482, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322590, Length=304, Percent_Identity=24.3421052631579, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323557, Length=337, Percent_Identity=24.3323442136499, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922554, Length=376, Percent_Identity=48.4042553191489, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41216; Mature: 41216

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIA
CCCCHHEHEEEECCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VLENGHAGFAFGSGMAAITATIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVD
HHHCCCCCEEECCCHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
TTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLAKEKDLLTIIDNTFMTPYWQS
CCCHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
HHHCCHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELAAEQANGFGAIISFD
HHHHHCCEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHCCCCEEEEEEC
VDSEETLNKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCEEEEEEEE
GIEDGEDLIEDLAQALA
CCCCCHHHHHHHHHHHC
>Mature Secondary Structure
MRAKTKLIHGIRIGEPSTGSVNVPIYQTSTYKQEAVGKHQGYEYSRTGNPTRAALEEMIA
CCCCHHEHEEEECCCCCCCEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
VLENGHAGFAFGSGMAAITATIMLFSKGDHVILTDDVYGGTYRVITKVLNRFGIEHTFVD
HHHCCCCCEEECCCHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEC
TTNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTLAKEKDLLTIIDNTFMTPYWQS
CCCHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEECCCCCCCCCCC
PISLGADIVLHSATKYLGGHSDVVAGLVVVNSPQLAEDLHFVQNSTGGILGPQDSFLLLR
HHHCCHHHHHHHHHHHHCCCHHHHEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHH
GLKTLGIRMEEHETNSRAIAEFLNNHPKVNKVYYPGLASHQNHELAAEQANGFGAIISFD
HHHHHCCEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHCCCCEEEEEEC
VDSEETLNKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDTLIRISV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCEEEEEEEE
GIEDGEDLIEDLAQALA
CCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]