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The map label for this gene is moeA [H]

Identifier: 52140782

GI number: 52140782

Start: 4569203

End: 4570492

Strand: Reverse

Name: moeA [H]

Synonym: BCZK4472

Alternate gene names: 52140782

Gene position: 4570492-4569203 (Counterclockwise)

Preceding gene: 52140777

Following gene: 52140781

Centisome position: 86.22

GC content: 41.4

Gene sequence:

>1290_bases
ATGGTAGAAAAACGAATTCCGATTCAAGTTGCTGAGGCAGTAGAGAGAGTAATGGAATATGCGAAAATTGGTGAAGTAGA
AGAGGTTTCTATTACGGAAAGTTACGGGAGAATTCTTGGGGAGGATGTTGTCTCTGATCATGACGTTCCTCATTTTGATC
GTTCTCCTTACGATGGTTTTGCAATTCGAGCAGAAGATACGAAAGAAGCAAATCAAGAGAATGCAATTGAGTTTGAAGTA
ATAGGGGAAATCGGGGCTGGATCTGTTTTTCTAGATGCAGTAGGATCTTTTCAGGCGGTTCGTATTATGACAGGAGCAGC
TATTCCAGCAGATTGTAATGCAGTCGTAATGCTAGAACTGACGGAAGGTTTTGAGAAGAACGGAAAAACATATATGAAGT
TAAAGCGTCCTTTTCATAGTGGCGACAATGTGTCATGTAAAGGGGAAGATATAAAAAAAAATCAAGTTCTCGTTAAGGAA
GGTGCTGTAATCAATCCAGGTGTTGCGGCCTTATTAGCGACGTTTGGATACAGTAATGTGAAGGTTGTAAAACAGCCAGT
TGTTGGTATTGTGACGACAGGAAGTGAATTGTTAGAAGTACATGAGTCATTACAGCCGGGGAAAATTAGAAATAGTAACT
CTTATATGATTGCCGCCCAAATTAAGAAAGCTGGGGGTAAAGTCCGTTATTATGGTCAACTTGCCGACGAGTTAGATGCA
TGTTTTACAGCCGTTCAATCGGCGATAGATGAGGTGGATATTTTAATTACGACAGGCGGTGTGTCGGTAGGAGATTATGA
CTACTTACCGGCTATTTATGAAAGGTTACAGGCGAATGTACTCTTTAATAAAATAGCAATGAGACCGGGCAGTGTAACGA
CAGTAGCTGAAGTGGATGGAAAGTTACTTTTCGGTTTATCAGGGAATCCGTCAGCTTGTTATGTAGGATTTGAGTTGTTT
GTGCATCCGGTTATAAAAACTTATTTGTATGCGAAGGAACCACACGTATATAGAGCAGATGCTATTTTACAAAAAGATTT
TCCAAAACCAAATCCGTTTACTCGTTTTGTAAGAGCAAAGGTGACAATCGTGGAAGGGGCATTACACGCGATGCCGGTCG
GTTTAGATAAATCGAGTGCGGTATCTTCACTTGCAGATGCGAATGCTTTTATTGTGTTGCCTGGAGGAACGAGAGGCTTT
GAGGCAGGGATGAAAGTGTCTGTATTATTGTTAGAGCACGCTGAGGGATGTGATTGGCCATGGGCAAAGCCCCTTCAATC
TTACAAATAG

Upstream 100 bases:

>100_bases
TGTGTGAATGAAGACATGGAATTCCTCCTTGAAGTAATTTCTATTTAATATATAAAGTTTAATCGAGATAAAAAAAATTG
CAAATATGGGGTGAGAAACG

Downstream 100 bases:

>100_bases
TAGGGTATCAAAATAGCGGGAAAACAACACTTGTTGAGAAAATTGTGCATGCATTAGCTGAACGGAAAATGAAAGTTGCT
ACCATTAAACATCACGGACA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFLDAVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSCKGEDIKKNQVLVKE
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIKKAGGKVRYYGQLADELDA
CFTAVQSAIDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVEGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
EAGMKVSVLLLEHAEGCDWPWAKPLQSYK

Sequences:

>Translated_429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFLDAVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSCKGEDIKKNQVLVKE
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIKKAGGKVRYYGQLADELDA
CFTAVQSAIDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVEGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
EAGMKVSVLLLEHAEGCDWPWAKPLQSYK
>Mature_429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFLDAVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSCKGEDIKKNQVLVKE
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIKKAGGKVRYYGQLADELDA
CFTAVQSAIDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVEGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
EAGMKVSVLLLEHAEGCDWPWAKPLQSYK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=398, Percent_Identity=32.6633165829146, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI10880983, Length=398, Percent_Identity=32.6633165829146, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787049, Length=374, Percent_Identity=31.283422459893, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147659, Length=390, Percent_Identity=27.9487179487179, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=366, Percent_Identity=24.0437158469945, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136978, Length=364, Percent_Identity=29.9450549450549, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24638841, Length=364, Percent_Identity=29.9450549450549, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46545; Mature: 46545

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEANQENAIEFEVIGEIGAGSVFLDAVGSFQAVRIMTGAAIPADCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCEEEEEHHCCCEEEEEEECCCCCCCCCEEEEEEE
TEGFEKNGKTYMKLKRPFHSGDNVSCKGEDIKKNQVLVKEGAVINPGVAALLATFGYSNV
ECCCCCCCCEEEEEECCCCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHHCCCCE
KVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIKKAGGKVRYYGQLADELDA
EEEECCCEEEEECCHHHHHHHHCCCCCCEECCCCEEEEEEEECCCCEEEEEHHHHHHHHH
CFTAVQSAIDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDG
HHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGFELFVHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAK
EEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCHHHHHHHEE
VTIVEGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGFEAGMKVSVLLLEHAEGCDWP
EEEEECCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAKPLQSYK
CCCHHHCCC
>Mature Secondary Structure
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGRILGEDVVSDHDVPHFDRSPYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEANQENAIEFEVIGEIGAGSVFLDAVGSFQAVRIMTGAAIPADCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCEEEEEHHCCCEEEEEEECCCCCCCCCEEEEEEE
TEGFEKNGKTYMKLKRPFHSGDNVSCKGEDIKKNQVLVKEGAVINPGVAALLATFGYSNV
ECCCCCCCCEEEEEECCCCCCCCCEECCCCCCCCEEEEECCCEECCCHHHHHHHHCCCCE
KVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIKKAGGKVRYYGQLADELDA
EEEECCCEEEEECCHHHHHHHHCCCCCCEECCCCEEEEEEEECCCCEEEEEHHHHHHHHH
CFTAVQSAIDEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDG
HHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGFELFVHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAK
EEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCHHHHHHHEE
VTIVEGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGFEAGMKVSVLLLEHAEGCDWP
EEEEECCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAKPLQSYK
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]