Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 52140762

GI number: 52140762

Start: 4589389

End: 4590612

Strand: Reverse

Name: napA [H]

Synonym: BCZK4492

Alternate gene names: 52140762

Gene position: 4590612-4589389 (Counterclockwise)

Preceding gene: 52140760

Following gene: 52140763

Centisome position: 86.6

GC content: 38.15

Gene sequence:

>1224_bases
ATGGATACTTTAATCTTTGAAGTTGGAACTGCGTTAGTATTAGTAGCTTTTGCAGCTATCCTTGCTGCGAAGTTAAAGTT
CTCGATTATTCCGTTTCTCATTATACTCGGTATGTTAGTGGGGCCTCATGCCCCAGATCTAGGACTTATCGATTTAAGGT
TTATTGAAAGCGGAGAAGTTATTTCCTTCCTCGGCCGCGTTGGCGTCATATTCCTCCTATTCTACTTAGGGTTAGAATTC
TCAATTAAAAAATTAATTAAATCAGGAAAATCAATTGCTTTCGGGGGGACTGTCCACATATCACTTAATTTCCTATTAGG
TTTGCTTTATGGATATGTGATGGGCTTCCCCTTATTAGAGACGTTAATTATTGCTGGAATCATTACAATTTCATCAAGTG
CAATTGTTGCAAAAGTCATTGTTGATTTAAGAAGATCTGGTAATAAAGAGACTGAGCTGATTTTAGGAATCATTATGTTT
GATGATATCTTTTTAGCGGTATATTTATCAGTCGTTTCAGGATTAGTACTCGGAGGGGCAACGTCATTTGTAGGTGCTCT
TACGTCGGTGTTAATTGCAGTAGGGTATATGCTCCTATTTTTTATAATCGCTAGAAAAGCTACGCCGTTTTTGAATAAAG
TATTAGATATTTCGTCTAACGAAATTTTCATAATCGTAATATTTGCTATTTTATTCTTCGTAGCAGGATTTTCCGAAACA
ATTCATGTTGCAGAAGCGATTGGAGCTTTATTATTAGGACTCGTCTTTTCTGAAACAGAGCATAGTGATCGAATTGAGAA
GCTCGTCGTCCCATTCCGTGATTTCTTTGGAGCCATATTCTTTTTCAGCTTCGGTTTAAGCATAGATCCGTTTTCGCTTG
GAGGAGCAGTCTGGTTGGCATTAGGAGCAGTTTTCATTACTTTAATCGGTAATTTTACTGCTGGAATGATTGCGGGGCGT
AAAGCCGGGTTATCCCATAAGACTTCTACGAATATAGGCTTAACACTCGTATCACGCGGGGAATTTTCTATTATTGTAGC
GAATATCGGCATTGCGGGTGGCTTAATGGCAGCGATTAAACCGTTCTCTGCTTTATATGTTTTAATATTGGCATCGTTAG
GACCGTTATTAACGAAAGAGTCTGGGAGAATATACTCTCTACTAGATAAGGTATTTAAATGGAGTGCTAAAGAACGTGCA
AAGCGAGAAAAAGAAGTTGGGTAA

Upstream 100 bases:

>100_bases
TATTATTGAAGCTGGTGATATGCTTGTGTTATCGGGCGCGAGACATGAAGTGAAAAGAATTATTAATGAATTGCTTTCAG
CAGGAGGTGATTCATAATCG

Downstream 100 bases:

>100_bases
TATATAAAGAGGCTGCATGAAGTTCATGCAGCCTCTTTATATATTGTTATTGTTGTCATTTTTTGTCGGTAAGTCGATAT
ATTCTAATAATCGCTGATAT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFVGALTSVLIAVGYMLLFFIIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITLIGNFTAGMIAGR
KAGLSHKTSTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKVFKWSAKERA
KREKEVG

Sequences:

>Translated_407_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFVGALTSVLIAVGYMLLFFIIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITLIGNFTAGMIAGR
KAGLSHKTSTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKVFKWSAKERA
KREKEVG
>Mature_407_residues
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEVISFLGRVGVIFLLFYLGLEF
SIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLETLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMF
DDIFLAVYLSVVSGLVLGGATSFVGALTSVLIAVGYMLLFFIIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLALGAVFITLIGNFTAGMIAGR
KAGLSHKTSTNIGLTLVSRGEFSIIVANIGIAGGLMAAIKPFSALYVLILASLGPLLTKESGRIYSLLDKVFKWSAKERA
KREKEVG

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=279, Percent_Identity=29.0322580645161, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786685, Length=351, Percent_Identity=27.6353276353276, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1786232, Length=262, Percent_Identity=25.9541984732824, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43647; Mature: 43647

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
ISFLGRVGVIFLLFYLGLEFSIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHHHHHHHHHHHHHHHHH
TLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMFDDIFLAVYLSVVSGLVLGGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSFVGALTSVLIAVGYMLLFFIIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGAVFITLIGNFTAGMIAGRKAGLSHKTSTNIGLTLVSRGEFSIIVANIGIAGGLMAAIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
PFSALYVLILASLGPLLTKESGRIYSLLDKVFKWSAKERAKREKEVG
HHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCC
>Mature Secondary Structure
MDTLIFEVGTALVLVAFAAILAAKLKFSIIPFLIILGMLVGPHAPDLGLIDLRFIESGEV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCHH
ISFLGRVGVIFLLFYLGLEFSIKKLIKSGKSIAFGGTVHISLNFLLGLLYGYVMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEHHHHHHHHHHHHHHHHHHHH
TLIIAGIITISSSAIVAKVIVDLRRSGNKETELILGIIMFDDIFLAVYLSVVSGLVLGGA
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
TSFVGALTSVLIAVGYMLLFFIIARKATPFLNKVLDISSNEIFIIVIFAILFFVAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRIEKLVVPFRDFFGAIFFFSFGLSIDPFSLGGAVWLA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
LGAVFITLIGNFTAGMIAGRKAGLSHKTSTNIGLTLVSRGEFSIIVANIGIAGGLMAAIK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCHHHHHHHHHH
PFSALYVLILASLGPLLTKESGRIYSLLDKVFKWSAKERAKREKEVG
HHHHHHHHHHHHHCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]