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The map label for this gene is glcR [H]

Identifier: 52140729

GI number: 52140729

Start: 4619692

End: 4620453

Strand: Reverse

Name: glcR [H]

Synonym: BCZK4526

Alternate gene names: 52140729

Gene position: 4620453-4619692 (Counterclockwise)

Preceding gene: 52140726

Following gene: 52140728

Centisome position: 87.16

GC content: 32.28

Gene sequence:

>762_bases
ATGAATCAAGAGGAACGTTTAATAAAAATAATGGAGTATTTGAATGAACATAGGACGATGAGTTTGAAGATAATGTGTGA
GCTATTTCAAGTCTCCAGAGATACAGCAAGAAGAGATATTGTAAAGTTAACAAATGAAACAACAATAGTGCGAACCCATG
GTGGTGTAGCTTTATCATCTTTCCACCATAAAATATCGGATTATGTAAATCGTGAGGAAAAAGAAATTGAATATAAGATA
TCTATTGGAAAGCGAGCTGCTTCTTTTGTAGAAGATAATGAAGTGATTTATCTTGATGTTTCAACAACTGTTAACTGTAT
GGCTTCATTTTTGACAGCAAGTAACATAACGGTTGTTACAAATTCAATTGATACAGTAAATCATTTAATGGATATGGAGA
ATGTAAATATTCATATTTTAGGTGGAGAATTAAATAAACACTCACGTTATATGACGGGTTTTTCTGCAATGGAGAAACTA
AAAGATTATCATTTTGATAAGGTTTTTATTGGTTCACCCGGTCTTACAGAAGATGGTGTCTATTATGCGTATGAGGAAGA
TATTCATTTTAAGCGTCAAATTGTTAAACAAACAAATGAGGTGTTTTTACTTGCTGATGAGACAAAAATGAATCAACGTC
AAAACTTTAAGGCGCTGTCATTAGAATCGATAGATACAATTATTACGAATGATGTTATTCCTGGCGATTTAGAACGAGTA
GTGAAAGAATATGGAATTGAGCTAATCGTTGGAGTGAAGTAA

Upstream 100 bases:

>100_bases
TCCTGTTTTAAGTTATTTTAAGGCTTATTTAATGGTTTTTGTTATGATATACTTAAAATAACTTAAAAGCACTTAAAAGT
AAATAAAAATGGGTGAGAGT

Downstream 100 bases:

>100_bases
AGGGGGACGTAAAAATGAAGGGGATTATATTTGATATTGACGGAACGATGTTAGATACGGAAAAAGCAGTTTTATATTCA
TTACAGAGAACGTTGCGAGA

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MNQEERLIKIMEYLNEHRTMSLKIMCELFQVSRDTARRDIVKLTNETTIVRTHGGVALSSFHHKISDYVNREEKEIEYKI
SIGKRAASFVEDNEVIYLDVSTTVNCMASFLTASNITVVTNSIDTVNHLMDMENVNIHILGGELNKHSRYMTGFSAMEKL
KDYHFDKVFIGSPGLTEDGVYYAYEEDIHFKRQIVKQTNEVFLLADETKMNQRQNFKALSLESIDTIITNDVIPGDLERV
VKEYGIELIVGVK

Sequences:

>Translated_253_residues
MNQEERLIKIMEYLNEHRTMSLKIMCELFQVSRDTARRDIVKLTNETTIVRTHGGVALSSFHHKISDYVNREEKEIEYKI
SIGKRAASFVEDNEVIYLDVSTTVNCMASFLTASNITVVTNSIDTVNHLMDMENVNIHILGGELNKHSRYMTGFSAMEKL
KDYHFDKVFIGSPGLTEDGVYYAYEEDIHFKRQIVKQTNEVFLLADETKMNQRQNFKALSLESIDTIITNDVIPGDLERV
VKEYGIELIVGVK
>Mature_253_residues
MNQEERLIKIMEYLNEHRTMSLKIMCELFQVSRDTARRDIVKLTNETTIVRTHGGVALSSFHHKISDYVNREEKEIEYKI
SIGKRAASFVEDNEVIYLDVSTTVNCMASFLTASNITVVTNSIDTVNHLMDMENVNIHILGGELNKHSRYMTGFSAMEKL
KDYHFDKVFIGSPGLTEDGVYYAYEEDIHFKRQIVKQTNEVFLLADETKMNQRQNFKALSLESIDTIITNDVIPGDLERV
VKEYGIELIVGVK

Specific function: Plays a role in carbon catabolite repression (CCR). Specifically required for transcriptional repression of the levanase operon by glucose but not by other sugars [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789059, Length=258, Percent_Identity=31.0077519379845, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI226510968, Length=249, Percent_Identity=30.9236947791165, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789829, Length=250, Percent_Identity=26.8, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789519, Length=250, Percent_Identity=25.6, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788069, Length=259, Percent_Identity=25.8687258687259, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1790753, Length=262, Percent_Identity=26.3358778625954, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082344, Length=249, Percent_Identity=23.6947791164659, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789170, Length=229, Percent_Identity=25.764192139738, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790635, Length=232, Percent_Identity=21.9827586206897, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 29084; Mature: 29084

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQEERLIKIMEYLNEHRTMSLKIMCELFQVSRDTARRDIVKLTNETTIVRTHGGVALSS
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHH
FHHKISDYVNREEKEIEYKISIGKRAASFVEDNEVIYLDVSTTVNCMASFLTASNITVVT
HHHHHHHHHCCCCCCEEEEEEECHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCEEEEE
NSIDTVNHLMDMENVNIHILGGELNKHSRYMTGFSAMEKLKDYHFDKVFIGSPGLTEDGV
CCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
YYAYEEDIHFKRQIVKQTNEVFLLADETKMNQRQNFKALSLESIDTIITNDVIPGDLERV
EEEEECCHHHHHHHHHCCCCEEEEECCCCCCHHHCCCEEEHHHHHHHHHCCCCCCHHHHH
VKEYGIELIVGVK
HHHCCCEEEEECC
>Mature Secondary Structure
MNQEERLIKIMEYLNEHRTMSLKIMCELFQVSRDTARRDIVKLTNETTIVRTHGGVALSS
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEHHH
FHHKISDYVNREEKEIEYKISIGKRAASFVEDNEVIYLDVSTTVNCMASFLTASNITVVT
HHHHHHHHHCCCCCCEEEEEEECHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCEEEEE
NSIDTVNHLMDMENVNIHILGGELNKHSRYMTGFSAMEKLKDYHFDKVFIGSPGLTEDGV
CCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCE
YYAYEEDIHFKRQIVKQTNEVFLLADETKMNQRQNFKALSLESIDTIITNDVIPGDLERV
EEEEECCHHHHHHHHHCCCCEEEEECCCCCCHHHCCCEEEHHHHHHHHHCCCCCCHHHHH
VKEYGIELIVGVK
HHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]