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The map label for this gene is hpt [H]

Identifier: 52140685

GI number: 52140685

Start: 4656616

End: 4657143

Strand: Direct

Name: hpt [H]

Synonym: BCZK4569

Alternate gene names: 52140685

Gene position: 4656616-4657143 (Clockwise)

Preceding gene: 52140692

Following gene: 52140686

Centisome position: 87.85

GC content: 33.33

Gene sequence:

>528_bases
ATGAATATTGAAATAAAAGACACTTTAATTTCTGAAGAACAATTACAAGAAAAAGTAAAAGAACTAGCACTTCAAATCGA
ACGTGACTTTGAAGGGGAAGAAATCGTAGTCATTGCTGTATTAAAAGGATCTTTCGTATTTGCTGCTGATTTAATTCGTC
ACATTAAAAACGATGTAACAATCGACTTTATTTCTGCATCTAGCTACGGAAATCAAACAGAAACAACTGGAAAAGTGAAA
CTATTAAAAGATATTGATGTAAACATTACTGGCAAAAACGTAATTGTCGTAGAAGACATTATCGATTCTGGTTTAACACT
TCACTTCTTAAAAGATCACTTCTTTATGCATAAACCAAAGGCACTCAAATTCTGTACGTTACTTGATAAACCTGAGCGTC
GTAAAGTAGACTTAAAAGCTGAATATGTTGGCTTCCAAATTCCAGACGAATTTATCGTTGGCTACGGTATCGACTGTGCA
GAAAAATACCGTAACTTACCATTTATTGCTTCAGTTGTAACGGAATAA

Upstream 100 bases:

>100_bases
TGTTATTGTATTTGTAAAAAATTACTATCTTCTTTGACTTTTTCCTTTCTATCCTTTACAGTCGAAATGTTCACAAGTTT
TACACTGTAGGAGGACTCCA

Downstream 100 bases:

>100_bases
TCGTATAACTTAAAAAATCGATAGTACATAAAATTTATATCGGCGATTTTCAAAATATATCTACCGTATCTTAAATTATA
TCGGCGATTTTTCAAAATAT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVTIDFISASSYGNQTETTGKVK
LLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPKALKFCTLLDKPERRKVDLKAEYVGFQIPDEFIVGYGIDCA
EKYRNLPFIASVVTE

Sequences:

>Translated_175_residues
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVTIDFISASSYGNQTETTGKVK
LLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPKALKFCTLLDKPERRKVDLKAEYVGFQIPDEFIVGYGIDCA
EKYRNLPFIASVVTE
>Mature_175_residues
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVTIDFISASSYGNQTETTGKVK
LLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPKALKFCTLLDKPERRKVDLKAEYVGFQIPDEFIVGYGIDCA
EKYRNLPFIASVVTE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=182, Percent_Identity=36.2637362637363, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI9910262, Length=174, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=6e-23,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=47.3372781065089, Blast_Score=176, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=35.3932584269663, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19877; Mature: 19877

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVT
CCEEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCE
IDFISASSYGNQTETTGKVKLLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPK
EEEEECCCCCCCCCCCCEEEEEEECCEEECCCEEEEEEHHHCCCCEEEEEHHHHHHCCCC
ALKFCTLLDKPERRKVDLKAEYVGFQIPDEFIVGYGIDCAEKYRNLPFIASVVTE
HHEEEHHCCCCCCCEEEEEEEEECEECCHHHEEECCCCHHHHHCCCCCHHHHHCC
>Mature Secondary Structure
MNIEIKDTLISEEQLQEKVKELALQIERDFEGEEIVVIAVLKGSFVFAADLIRHIKNDVT
CCEEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCE
IDFISASSYGNQTETTGKVKLLKDIDVNITGKNVIVVEDIIDSGLTLHFLKDHFFMHKPK
EEEEECCCCCCCCCCCCEEEEEEECCEEECCCEEEEEEHHHCCCCEEEEEHHHHHHCCCC
ALKFCTLLDKPERRKVDLKAEYVGFQIPDEFIVGYGIDCAEKYRNLPFIASVVTE
HHEEEHHCCCCCCCEEEEEEEEECEECCHHHEEECCCCHHHHHCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]