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The map label for this gene is guaD [H]

Identifier: 52140651

GI number: 52140651

Start: 4689920

End: 4690381

Strand: Direct

Name: guaD [H]

Synonym: BCZK4602

Alternate gene names: 52140651

Gene position: 4689920-4690381 (Clockwise)

Preceding gene: 52140653

Following gene: 52140642

Centisome position: 88.47

GC content: 33.55

Gene sequence:

>462_bases
ATGAGTCACAAAGAATTTATGAAATTAGCAATAGATTTAGCTTACAACAATACAAAAAATGAAAAAGGGAAACCATTTGG
TGCAGTACTTGTTAAAGATGGTGAAATTGTTGCAAAGGGAGTAAATGAGGTTCTTACAACACATGATCCTACTGCGCATG
CTGAACTTTTAACTATCCGTGAGGCTTGTCGTATTCTTAGTACATCTGACCTTTCCGATTGTATACTATACGCAAGTGGA
GAACCTTGTCCAATGTGTTTAAGCGCTATTTACTGGGCGAATCTTAAACATGTTTATTATTCCTATACTTCACAAGAGGA
AGAAGAAATTGGATTAGGAACAAAATATGTCTATCAGCAAATAGCTCTTCCAACAGAACAACGAGACATAAAATTATTAA
AAATTGATAAAAGTCATTATGAAAAAAATCCATTTGCCCTTTGGAAAGAAAAGAATAAGTGA

Upstream 100 bases:

>100_bases
CATCGTTGGTACGATTATCGTAATTATGCTAGAACAACTATGGAAAACAAAAAAAGCGAGCGAAAAAAATCATGTTTAAT
TTTTAAGGGAGGGTTTCTAA

Downstream 100 bases:

>100_bases
TATATGTAGCGGAACTTGCTTTATGAGAAAAATAGCCGTGGTAATTATAGCTTCTTCGACGCTATGCTTAAAAGTAAAGT
GAGAATCCATATTACAATTT

Product: cytidine/deoxycytidylate deaminase family protein; guanine deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 153; Mature: 152

Protein sequence:

>153_residues
MSHKEFMKLAIDLAYNNTKNEKGKPFGAVLVKDGEIVAKGVNEVLTTHDPTAHAELLTIREACRILSTSDLSDCILYASG
EPCPMCLSAIYWANLKHVYYSYTSQEEEEIGLGTKYVYQQIALPTEQRDIKLLKIDKSHYEKNPFALWKEKNK

Sequences:

>Translated_153_residues
MSHKEFMKLAIDLAYNNTKNEKGKPFGAVLVKDGEIVAKGVNEVLTTHDPTAHAELLTIREACRILSTSDLSDCILYASG
EPCPMCLSAIYWANLKHVYYSYTSQEEEEIGLGTKYVYQQIALPTEQRDIKLLKIDKSHYEKNPFALWKEKNK
>Mature_152_residues
SHKEFMKLAIDLAYNNTKNEKGKPFGAVLVKDGEIVAKGVNEVLTTHDPTAHAELLTIREACRILSTSDLSDCILYASGE
PCPMCLSAIYWANLKHVYYSYTSQEEEEIGLGTKYVYQQIALPTEQRDIKLLKIDKSHYEKNPFALWKEKNK

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=100, Percent_Identity=35, Blast_Score=74, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554608, Length=150, Percent_Identity=43.3333333333333, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17555996, Length=150, Percent_Identity=41.3333333333333, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17541138, Length=152, Percent_Identity=32.8947368421053, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17401; Mature: 17270

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHKEFMKLAIDLAYNNTKNEKGKPFGAVLVKDGEIVAKGVNEVLTTHDPTAHAELLTIR
CCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEHHHHHHHHHCCCCCHHHHHHHHH
EACRILSTSDLSDCILYASGEPCPMCLSAIYWANLKHVYYSYTSQEEEEIGLGTKYVYQQ
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHCCCHHHHHHH
IALPTEQRDIKLLKIDKSHYEKNPFALWKEKNK
HCCCCCCCCEEEEEEEHHHCCCCCEEEEECCCC
>Mature Secondary Structure 
SHKEFMKLAIDLAYNNTKNEKGKPFGAVLVKDGEIVAKGVNEVLTTHDPTAHAELLTIR
CHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEHHHHHHHHHCCCCCHHHHHHHHH
EACRILSTSDLSDCILYASGEPCPMCLSAIYWANLKHVYYSYTSQEEEEIGLGTKYVYQQ
HHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHCCCHHHHHHH
IALPTEQRDIKLLKIDKSHYEKNPFALWKEKNK
HCCCCCCCCEEEEEEEHHHCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]