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The map label for this gene is trxB [H]

Identifier: 52140407

GI number: 52140407

Start: 4939881

End: 4940846

Strand: Reverse

Name: trxB [H]

Synonym: BCZK4851

Alternate gene names: 52140407

Gene position: 4940846-4939881 (Counterclockwise)

Preceding gene: 52140406

Following gene: 52140409

Centisome position: 93.21

GC content: 38.61

Gene sequence:

>966_bases
GTGAATAGTGTGTCAGAAGAAAAAATTTATGATGTCATTATTATTGGTGCAGGACCAGCTGGTATGACAGCTGCAGTATA
TACATCTCGTGCGAATTTAAGCACATTAATGCTTGAGCGTGGTATTCCAGGCGGACAAATGGCAAATACAGAAGATGTAG
AAAACTACCCAGGTTATGAGTCTATTTTAGGACCAGACTTATCAAATAAAATGTTCGAGCATGCGAAGAAATTTGGTGCT
GAATATGCATACGGTGATGTGAAAGAAGTCATCGATGGTAAAGAATACAAAACAATTATTGCTGGTAAAAAAGAATATAA
AGCACGTGCAATTATCGTTGCAAGTGGTGCAGAGTATAAAAAAATTGGTGTACCAGGTGAAACAGAACTTGGCGGCCGCG
GTGTATCATATTGTGCGGTATGTGATGGCGCATTCTTTAAAGGTAAAGAACTTGTAGTTATCGGCGGCGGAGATTCTGCT
GTTGAAGAGGGTGTGTTCTTAACACGCTTCGCATCAAAAGTAACGATCGTTCACCGTCGTGACACGCTTCGTGCACAGAA
AATTTTACAAGATCGTGCTTTCCAAAACGAAAAAGTAGACTTCATTTGGAACCACACGATAAAAGAAATTAACGAAGCAA
ATGGTAAAGTAGGAAGTGTAACACTTGTAGATGTAAACAGTGGAGAAGAGAAAGAAGTCAAAACTGACGGCGTATTCGTA
TACATCGGTATGTTACCACTATCAAAACCATTTGTTGAACTAGGTATTACAAATGAAAATGGTTACCTTGAAACAAACGA
GCGTATGGAAACGAAAGTTCCTGGTATTTTTGCAGCAGGTGATGTTCGTGAAAAAATGCTACGTCAAATTGTAACTGCAA
CAGGTGATGGTAGTATTGCAGCACAAAGTGCACAACATTACGTAGAAGAATTATTAGAAGAACTAAAAACCGTATCAGAA
AAATAA

Upstream 100 bases:

>100_bases
AGCTGTTAAGCGTACGCACACATAAGTAAGCAAATCATTGGGAAAAAAATGATGCGAACAGTATAATGAGGGTAACTTAA
TTGTGTAGGAATGAATAGGA

Downstream 100 bases:

>100_bases
GGGATAACATACCTTTTGAGAAGAAAGCTACCGATAGGAGCTTTCTTCTTTTTTATGAAAATGTCAAAGTTTTGTCAAAA
AATATTGGGATTATAAGCTT

Product: thioredoxin-disulfide reductase (thioredoxin reductase (NADPH))

Products: NA

Alternate protein names: TRXR; General stress protein 35; GSP35 [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MNSVSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESILGPDLSNKMFEHAKKFGA
EYAYGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSA
VEEGVFLTRFASKVTIVHRRDTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFV
YIGMLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQSAQHYVEELLEELKTVSE
K

Sequences:

>Translated_321_residues
MNSVSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESILGPDLSNKMFEHAKKFGA
EYAYGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSA
VEEGVFLTRFASKVTIVHRRDTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFV
YIGMLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQSAQHYVEELLEELKTVSE
K
>Mature_321_residues
MNSVSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYESILGPDLSNKMFEHAKKFGA
EYAYGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYKKIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSA
VEEGVFLTRFASKVTIVHRRDTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFV
YIGMLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIAAQSAQHYVEELLEELKTVSE
K

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=327, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI226437568, Length=327, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI65787454, Length=327, Percent_Identity=23.8532110091743, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787114, Length=313, Percent_Identity=38.6581469648562, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI87081763, Length=305, Percent_Identity=35.7377049180328, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6320560, Length=313, Percent_Identity=38.6581469648562, Blast_Score=203, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6321898, Length=312, Percent_Identity=38.4615384615385, Blast_Score=187, Evalue=1e-48,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 34970; Mature: 34970

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00573 PYRIDINE_REDOX_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYE
CCCCCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHH
SILGPDLSNKMFEHAKKFGAEYAYGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYK
HHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCEE
KIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSAVEEGVFLTRFASKVTIVHRR
EECCCCCCCCCCCCCEEEEEECCCEECCCEEEEEECCCHHHHCCCCEEEHHCEEEEEECH
DTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFV
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCCEEE
YIGMLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIA
EEEECCCCCCEEEEEEECCCCEEECCCCHHHCCCCEEECCHHHHHHHHHHHHCCCCCCHH
AQSAQHYVEELLEELKTVSEK
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNSVSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMLERGIPGGQMANTEDVENYPGYE
CCCCCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHH
SILGPDLSNKMFEHAKKFGAEYAYGDVKEVIDGKEYKTIIAGKKEYKARAIIVASGAEYK
HHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCEE
KIGVPGETELGGRGVSYCAVCDGAFFKGKELVVIGGGDSAVEEGVFLTRFASKVTIVHRR
EECCCCCCCCCCCCCEEEEEECCCEECCCEEEEEECCCHHHHCCCCEEEHHCEEEEEECH
DTLRAQKILQDRAFQNEKVDFIWNHTIKEINEANGKVGSVTLVDVNSGEEKEVKTDGVFV
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCEEECCCEEE
YIGMLPLSKPFVELGITNENGYLETNERMETKVPGIFAAGDVREKMLRQIVTATGDGSIA
EEEECCCCCCEEEEEEECCCCEEECCCCHHHCCCCEEECCHHHHHHHHHHHHCCCCCCHH
AQSAQHYVEELLEELKTVSEK
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9298659 [H]