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The map label for this gene is mtaD [H]

Identifier: 161763544

GI number: 161763544

Start: 1772850

End: 1774157

Strand: Direct

Name: mtaD [H]

Synonym: BCZK1681

Alternate gene names: 161763544

Gene position: 1772850-1774157 (Clockwise)

Preceding gene: 52143554

Following gene: 52143551

Centisome position: 33.44

GC content: 37.77

Gene sequence:

>1308_bases
TTGAAAACAACTTATGTAAACGCTACAATTGTAACGATGAATGAACAAAATGAAGTGATAGAAAATGGATATATCATTGT
AGAAAATGATCAAATTATAGATGTAAAGAGTGGAGAATTCGCTAGTGATTTTGAAGTAGATGAAGTAATTGACATGAAAG
GAAAGTGGGTTTTACCAGGTCTTGTCAATACACATACACACGTTGTAATGAGTCTCTTAAGAGGTATTGGTGATGATATG
TTGTTACAACCATGGCTTGAGACGAGAATTTGGCCACTTGAAAGTCAATTTACTCCCCAAATTGCAGTCGCTAGTACGGA
ATTAGGATTACTTGAAATGGTGAAAAGCGGTACAACATCATTCTCTGATATGTTTAATCCAATTGGAGTAGATCAAGATG
CAATTATGGAAACGGTATCAAGAAGCGGAATGCGAGCTGCTGTTTCAAGAACTTTATTTAGCTTTGGAACGAAAGAAGAT
GAAAAGAAAGCAATTGAAGAAGCTGAGAGATATGTGAAGCGTTACTATAACGAAAGTGGCATGTTAACTACGATGGTTGC
ACCGCATAGTCCATATACATGCAGTACAGAACTGTTAGAAGAGTGTGCACGTATTGCAGTAGAAAATCGAACGATGGTTC
ATATTCACCTTTCCGAAACAGAGCGTGAAGTACGTGATATTGAAGCACAGTACGGAAAACGTCCAGTAGAATATGCGGCA
AGTTGCGGGTTGTTTAAACGACCAACAGTGATTGCTCACGGTGTAGTATTAAATGACAGTGAGCGTGCATTTTTAGCGGA
ACATGACGTTCGAGTAGCTCATAATCCGAATAGTAATTTAAAATTAGGTTCTGGTATAGCGAATGTAAAAGCGATGCTAG
AAGCAGGAATAAAAGTAGGAATTGCAACAGATAGTGTTGCATCTAACAATAATTTAGATATGTTTGAAGAAATGCGCATA
GCGACTTTACTACAAAAAGGTATTCATCAAGATGCAACAGCGTTACCGGTTGAAACAGCTCTTACACTTGCAACTAAAGG
AGCGGCTGAAGTAATCGGCATGAAACAAACGGGATCACTTGAGGTTGGAAAGTGTGCTGATTTCATTACAATTGATCCAT
CTAATAAGCCTCATTTACAACCAGCGGATGAAGTGTTATCACACCTTGTATATGCTGCTAGTGGAAAAGATATAAGCGAT
GTAATTATTAACGGAAAACGTGTCGTTTGGAATGGCGAATGTAAAACGTTAGATGAAGAGCGTATTATATTTGAAGCAAG
TCGTTATAAACGAGGTTTACAAAGATAG

Upstream 100 bases:

>100_bases
AAGAATTGAAATTATCTTTTGACTCTTAATCTTTAATAAGTTACTATAATGGTGGTAACTTATTAAAGGGAACTTCATAG
AGTTGAAAGGGGAAATACTT

Downstream 100 bases:

>100_bases
GTATTTTTAGGCTGTGGAGAAAGACTTCTCCACAGCCTGTTTTTGTGTCTGAACCTTTTTTATTAATAAAACAGAAGAGA
ATGATTTAGATAAAATCACT

Product: chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGEFASDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKED
EKKAIEEAERYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENRTMVHIHLSETEREVRDIEAQYGKRPVEYAA
SCGLFKRPTVIAHGVVLNDSERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKRVVWNGECKTLDEERIIFEASRYKRGLQR

Sequences:

>Translated_435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGEFASDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKED
EKKAIEEAERYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENRTMVHIHLSETEREVRDIEAQYGKRPVEYAA
SCGLFKRPTVIAHGVVLNDSERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKRVVWNGECKTLDEERIIFEASRYKRGLQR
>Mature_435_residues
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGEFASDFEVDEVIDMKGKWVLPGLVNTHTHVVMSLLRGIGDDM
LLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTSFSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKED
EKKAIEEAERYVKRYYNESGMLTTMVAPHSPYTCSTELLEECARIAVENRTMVHIHLSETEREVRDIEAQYGKRPVEYAA
SCGLFKRPTVIAHGVVLNDSERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVGIATDSVASNNNLDMFEEMRI
ATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSLEVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISD
VIINGKRVVWNGECKTLDEERIIFEASRYKRGLQR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=381, Percent_Identity=27.8215223097113, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789249, Length=339, Percent_Identity=26.8436578171091, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082177, Length=444, Percent_Identity=25.6756756756757, Blast_Score=105, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17540282, Length=388, Percent_Identity=25, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319963, Length=351, Percent_Identity=27.9202279202279, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24643849, Length=443, Percent_Identity=26.410835214447, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48140; Mature: 48140

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGEFASDFEVDEVIDMKGKWVLPG
CCEEEEEEEEEEECCCCHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCEECCC
LVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCC
FSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAERYVKRYYNESG
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
MLTTMVAPHSPYTCSTELLEECARIAVENRTMVHIHLSETEREVRDIEAQYGKRPVEYAA
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHH
SCGLFKRPTVIAHGVVLNDSERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVG
HCCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSL
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEEECCCCCE
EVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKRVVWNGECKTLDEE
ECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCCCCCCCCH
RIIFEASRYKRGLQR
HHEEEHHHHHHCCCC
>Mature Secondary Structure
MKTTYVNATIVTMNEQNEVIENGYIIVENDQIIDVKSGEFASDFEVDEVIDMKGKWVLPG
CCEEEEEEEEEEECCCCHHHHCCEEEEECCEEEEECCCCCCCCCCHHHHHCCCCCEECCC
LVNTHTHVVMSLLRGIGDDMLLQPWLETRIWPLESQFTPQIAVASTELGLLEMVKSGTTS
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCC
FSDMFNPIGVDQDAIMETVSRSGMRAAVSRTLFSFGTKEDEKKAIEEAERYVKRYYNESG
HHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
MLTTMVAPHSPYTCSTELLEECARIAVENRTMVHIHLSETEREVRDIEAQYGKRPVEYAA
CEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHH
SCGLFKRPTVIAHGVVLNDSERAFLAEHDVRVAHNPNSNLKLGSGIANVKAMLEAGIKVG
HCCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEECCCHHHHHHHHHCCCEEE
IATDSVASNNNLDMFEEMRIATLLQKGIHQDATALPVETALTLATKGAAEVIGMKQTGSL
EEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHEEECCCCCE
EVGKCADFITIDPSNKPHLQPADEVLSHLVYAASGKDISDVIINGKRVVWNGECKTLDEE
ECCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHEECCCEEEECCCCCCCCCH
RIIFEASRYKRGLQR
HHEEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA