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The map label for this gene is tmk

Identifier: 51894393

GI number: 51894393

Start: 3477337

End: 3477981

Strand: Reverse

Name: tmk

Synonym: STH3258

Alternate gene names: 51894393

Gene position: 3477981-3477337 (Counterclockwise)

Preceding gene: 51894394

Following gene: 51894392

Centisome position: 97.53

GC content: 69.3

Gene sequence:

>645_bases
GTGTCGGTGTTCATCAGCTTCGAGGGGGTCGACGGCTCCGGCAAGTCGACCCAGATCCGGCTCCTGTTGCAGTACCTCGA
CGAGCAGAGCGTGCCGTACGTCTTCACCCGGGAGCCCGGCGGCACCCCGATCGCGGAGCAGATCCGCAGGGTCCTCCTCG
ACCCGGCGAACCGGGGGATGTCGGTGATCACGGAGGCCCTCCTGTTCGCGGCGGCCCGTGCCGAGCACGTGAGCCGTACG
ATCCGGCCGGCCCTGGAGGAGGGAAAGGTGGTCATCTGCGACCGCTTTGTCGACTCGTCCCTGGTGTACCAGGGGGTGGC
CGGGGGGCTGCCCGTGGAGTTCCTGACGCAGATCAACGAGATGGCTACTGGCGCCCTGCGCCCGCATCGCACCATCGTGC
TCGACCTGGCCCCCGAGGTGGCCCTGGCCAGGCGGACCGGGGAGGAGGCCGACCGGATCGAGCGCCAGTCCCGGGAGTAC
CACCAGCTGGTCCGGGAGGGCTACCTGGATCTGGCCCGGGCAGAGCCCCGGCGGGTGAAGGTGGTCGATGCGTCCAGGAG
CGTAGAAGAAGTACAGAAGGATATTCGGCGGCTGGTGGAGGAGGTGCTGCCCCGCCGGTTTCGCGGGGCCGGGACCAGAC
CGTGA

Upstream 100 bases:

>100_bases
GCTGGACTACCTCCGGCGCGCCGCCGATGCCGGCTGGCACCTTCAGGGCCCGGCAGACCCCGCGCTGCGAAGCATCCAGG
TCGTGGAGGAGTGAACCGCG

Downstream 100 bases:

>100_bases
GCGAAAGGGGGGCGAACCCGGGTGAAACTGATCATCGCGATCGTTCAGGACAAGGATACGCACCGGCTGCTGTCGGCCCT
GACCCAGGAGGGCTTCCGCG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSVFISFEGVDGSGKSTQIRLLLQYLDEQSVPYVFTREPGGTPIAEQIRRVLLDPANRGMSVITEALLFAAARAEHVSRT
IRPALEEGKVVICDRFVDSSLVYQGVAGGLPVEFLTQINEMATGALRPHRTIVLDLAPEVALARRTGEEADRIERQSREY
HQLVREGYLDLARAEPRRVKVVDASRSVEEVQKDIRRLVEEVLPRRFRGAGTRP

Sequences:

>Translated_214_residues
MSVFISFEGVDGSGKSTQIRLLLQYLDEQSVPYVFTREPGGTPIAEQIRRVLLDPANRGMSVITEALLFAAARAEHVSRT
IRPALEEGKVVICDRFVDSSLVYQGVAGGLPVEFLTQINEMATGALRPHRTIVLDLAPEVALARRTGEEADRIERQSREY
HQLVREGYLDLARAEPRRVKVVDASRSVEEVQKDIRRLVEEVLPRRFRGAGTRP
>Mature_213_residues
SVFISFEGVDGSGKSTQIRLLLQYLDEQSVPYVFTREPGGTPIAEQIRRVLLDPANRGMSVITEALLFAAARAEHVSRTI
RPALEEGKVVICDRFVDSSLVYQGVAGGLPVEFLTQINEMATGALRPHRTIVLDLAPEVALARRTGEEADRIERQSREYH
QLVREGYLDLARAEPRRVKVVDASRSVEEVQKDIRRLVEEVLPRRFRGAGTRP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=203, Percent_Identity=39.4088669950739, Blast_Score=128, Evalue=3e-31,
Organism=Drosophila melanogaster, GI28573735, Length=212, Percent_Identity=29.7169811320755, Blast_Score=70, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_SYMTH (Q67JB0)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_077084.1
- ProteinModelPortal:   Q67JB0
- SMR:   Q67JB0
- GeneID:   2979963
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3258
- NMPDR:   fig|292459.1.peg.3128
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- BioCyc:   STHE292459:STH3258-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23978; Mature: 23847

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFISFEGVDGSGKSTQIRLLLQYLDEQSVPYVFTREPGGTPIAEQIRRVLLDPANRGM
CEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCH
SVITEALLFAAARAEHVSRTIRPALEEGKVVICDRFVDSSLVYQGVAGGLPVEFLTQINE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCHHHHHHHHH
MATGALRPHRTIVLDLAPEVALARRTGEEADRIERQSREYHQLVREGYLDLARAEPRRVK
HHHCCCCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VVDASRSVEEVQKDIRRLVEEVLPRRFRGAGTRP
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SVFISFEGVDGSGKSTQIRLLLQYLDEQSVPYVFTREPGGTPIAEQIRRVLLDPANRGM
EEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCH
SVITEALLFAAARAEHVSRTIRPALEEGKVVICDRFVDSSLVYQGVAGGLPVEFLTQINE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHCCCCCCHHHHHHHHH
MATGALRPHRTIVLDLAPEVALARRTGEEADRIERQSREYHQLVREGYLDLARAEPRRVK
HHHCCCCCCCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VVDASRSVEEVQKDIRRLVEEVLPRRFRGAGTRP
EEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA