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The map label for this gene is fhs

Identifier: 51894324

GI number: 51894324

Start: 3396482

End: 3398152

Strand: Reverse

Name: fhs

Synonym: STH3189

Alternate gene names: 51894324

Gene position: 3398152-3396482 (Counterclockwise)

Preceding gene: 51894325

Following gene: 51894323

Centisome position: 95.29

GC content: 68.76

Gene sequence:

>1671_bases
TTGCTCTCCGACATCGCAATTGCGCAGCGTGCACGGCTTGAACCGATCACGAAGGTGGCAGAGCAGATCGGACTGGGTCC
CGAAGACCTGGAGCTGTACGGCCGCTATAAGGCCAAGGTGGCCGACCACGTGTGGCCCCGCGTGAGGTCCAACCCCGACG
GCAAGCTGATCCTGGTCACCGCCATCAGCCCGACGCCTGCCGGCGAGGGCAAGACCACGGTGACGGTGGGCCTGGGCCAG
GCGATGTCCCGCATCGGGAAGCGGGCGATCATCGCCCTCCGGGAGCCCTCGCTGGGGCCGGCGTTCGGCGTGAAGGGCGG
CGCGGCCGGCGGCGGCTACTCGCAGGTCGTTCCCATGGATGAGATCAACCTGCACTTCACCGGCGACTTCCACGCCGTGA
CGGCGGCCAACAACCTGCTGGCGGCGATGATCGACAACCACCTCCACCAGGGCAACAAACTGGGCCTCGACCCGCGGCAG
ATCACCTTCAAGCGGGTCCTGGACATGAACGACCGGGCCCTGCGGTCCGTGGTCATCGGTCTCGGCGGCAAGAACGGCGG
CGTGCCGCGCCAGGAGGAGTTCATGATCACCCCGGCGTCGGAGGTCATGGCGACGCTCTGCCTGGCGGAGGACCTGGCCG
ACCTGAAGCGACGCTGCGGTGAGATCATCGTCGGCTACACCTACGACGGCGCCCCGGTGCGGGCCCGGGACCTGAAGGCG
GAAGGGGCGATGGCCACCCTCCTGAAGGAAGCCATCAAGCCCAACCTGGTGCAGACGCTGGAGAACACTCCGGCCTTCGT
GCACGGCGGGCCCTTCGCCAACATCGCCCACGGGTGCAACACCGTCGTGGCGACCCGGCTCGCCCTGAAGCTGGCCGACT
ACGTGATCACGGAGGCCGGCTTCGGTGCGGACCTGGGGGCGGAGAAGTTCATTGACATCAAGTGCCGGCTCTCCGGGCTG
CGCCCCGACGCCGTGGTGGTGGTGGCCACCATCCGCTCGCTGAAGATGCACGGCGGCCTGAAGAAGGACGATCTGGCCCG
GGAGGACCTGGAGGCCCTGCAGCGGGGCAGCGCCAACCTCATGCGTCACCTCCGCAACGTGACCGAGGTCTTCGGACTGC
CGGCGGTCGTCGCGATCAACCGTTTTGCGGCCGACACCGAAGCCGAGATTGCCCTGCTGCGGGCACTGGTGGAGGAGGCC
GGCGCCACGGCCGTGGTGGCGGACGTCCACGCCCGGGGCGGCGACGGCGGCATCGAGCTGGCGCAGCGGGTGGTGGAGCT
GGTTGAACAGCCGAACCGGTTCCGCTTCGCCTACGACGACGAGGACAGCCTGAAGACCAAGATCGAGAAGGTCGCCACGC
GGATCTACGGCGCCGACGGCGTCGATTTTACCCGGGAGGCCAGCCGCATGCTGAAGAAGCTGGAGAGCGAGGGCTTCGGC
CGCGCACCGGTCTGCATCGCGAAGACCCAGTACTCGTTCTCCGACGACCCCAAGAAGTTGGGCGCGCCCACGGGCTGGCG
GCTGACCGTCCGCGAGGTGCGGCCCAGCGCCGGCGCGGGCTTCGTGGTGGCGCTCACCGGCGAGATCATGACCATGCCCG
GCCTGCCGCCGGTGCCCGCCGCGGAGAGCATCGACGTCTCCGACGACGGGGAGATCACAGGGCTGTTCTAG

Upstream 100 bases:

>100_bases
GTGCTGCAGGCCTTCCACAGCCTGGTTCCGGATCCGGTGGTGCGGTTCCTGAAGCAGCAGTAGCAGTCCAGCGGAGTGAC
CAGTGGAGGAGGAACGGACC

Downstream 100 bases:

>100_bases
CCGGACCGGGCGCTGTTCGCTTCCGCAGGAAGGGAGAGGCGGAGGCCGGGGCGAATCCCTCCCCGGCCTTCGCACATTCA
GAGACGAGGTGACCTGAATC

Product: formate-tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 556; Mature: 556

Protein sequence:

>556_residues
MLSDIAIAQRARLEPITKVAEQIGLGPEDLELYGRYKAKVADHVWPRVRSNPDGKLILVTAISPTPAGEGKTTVTVGLGQ
AMSRIGKRAIIALREPSLGPAFGVKGGAAGGGYSQVVPMDEINLHFTGDFHAVTAANNLLAAMIDNHLHQGNKLGLDPRQ
ITFKRVLDMNDRALRSVVIGLGGKNGGVPRQEEFMITPASEVMATLCLAEDLADLKRRCGEIIVGYTYDGAPVRARDLKA
EGAMATLLKEAIKPNLVQTLENTPAFVHGGPFANIAHGCNTVVATRLALKLADYVITEAGFGADLGAEKFIDIKCRLSGL
RPDAVVVVATIRSLKMHGGLKKDDLAREDLEALQRGSANLMRHLRNVTEVFGLPAVVAINRFAADTEAEIALLRALVEEA
GATAVVADVHARGGDGGIELAQRVVELVEQPNRFRFAYDDEDSLKTKIEKVATRIYGADGVDFTREASRMLKKLESEGFG
RAPVCIAKTQYSFSDDPKKLGAPTGWRLTVREVRPSAGAGFVVALTGEIMTMPGLPPVPAAESIDVSDDGEITGLF

Sequences:

>Translated_556_residues
MLSDIAIAQRARLEPITKVAEQIGLGPEDLELYGRYKAKVADHVWPRVRSNPDGKLILVTAISPTPAGEGKTTVTVGLGQ
AMSRIGKRAIIALREPSLGPAFGVKGGAAGGGYSQVVPMDEINLHFTGDFHAVTAANNLLAAMIDNHLHQGNKLGLDPRQ
ITFKRVLDMNDRALRSVVIGLGGKNGGVPRQEEFMITPASEVMATLCLAEDLADLKRRCGEIIVGYTYDGAPVRARDLKA
EGAMATLLKEAIKPNLVQTLENTPAFVHGGPFANIAHGCNTVVATRLALKLADYVITEAGFGADLGAEKFIDIKCRLSGL
RPDAVVVVATIRSLKMHGGLKKDDLAREDLEALQRGSANLMRHLRNVTEVFGLPAVVAINRFAADTEAEIALLRALVEEA
GATAVVADVHARGGDGGIELAQRVVELVEQPNRFRFAYDDEDSLKTKIEKVATRIYGADGVDFTREASRMLKKLESEGFG
RAPVCIAKTQYSFSDDPKKLGAPTGWRLTVREVRPSAGAGFVVALTGEIMTMPGLPPVPAAESIDVSDDGEITGLF
>Mature_556_residues
MLSDIAIAQRARLEPITKVAEQIGLGPEDLELYGRYKAKVADHVWPRVRSNPDGKLILVTAISPTPAGEGKTTVTVGLGQ
AMSRIGKRAIIALREPSLGPAFGVKGGAAGGGYSQVVPMDEINLHFTGDFHAVTAANNLLAAMIDNHLHQGNKLGLDPRQ
ITFKRVLDMNDRALRSVVIGLGGKNGGVPRQEEFMITPASEVMATLCLAEDLADLKRRCGEIIVGYTYDGAPVRARDLKA
EGAMATLLKEAIKPNLVQTLENTPAFVHGGPFANIAHGCNTVVATRLALKLADYVITEAGFGADLGAEKFIDIKCRLSGL
RPDAVVVVATIRSLKMHGGLKKDDLAREDLEALQRGSANLMRHLRNVTEVFGLPAVVAINRFAADTEAEIALLRALVEEA
GATAVVADVHARGGDGGIELAQRVVELVEQPNRFRFAYDDEDSLKTKIEKVATRIYGADGVDFTREASRMLKKLESEGFG
RAPVCIAKTQYSFSDDPKKLGAPTGWRLTVREVRPSAGAGFVVALTGEIMTMPGLPPVPAAESIDVSDDGEITGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=620, Percent_Identity=44.6774193548387, Blast_Score=479, Evalue=1e-135,
Organism=Homo sapiens, GI36796743, Length=620, Percent_Identity=44.1935483870968, Blast_Score=461, Evalue=1e-130,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=39.5061728395062, Blast_Score=70, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17568737, Length=624, Percent_Identity=44.8717948717949, Blast_Score=465, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17568739, Length=624, Percent_Identity=44.8717948717949, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319558, Length=631, Percent_Identity=42.4722662440571, Blast_Score=474, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=44.5686900958466, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24645718, Length=620, Percent_Identity=43.8709677419355, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=620, Percent_Identity=43.8709677419355, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=620, Percent_Identity=43.8709677419355, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=620, Percent_Identity=43.8709677419355, Blast_Score=469, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_SYMTH (Q67JH9)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_077015.1
- ProteinModelPortal:   Q67JH9
- SMR:   Q67JH9
- GeneID:   2981679
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3189
- NMPDR:   fig|292459.1.peg.3060
- HOGENOM:   HBG677721
- OMA:   KMPGLPK
- BioCyc:   STHE292459:STH3189-MONOMER
- BRENDA:   6.3.4.3
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59451; Mature: 59451

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDIAIAQRARLEPITKVAEQIGLGPEDLELYGRYKAKVADHVWPRVRSNPDGKLILVT
CCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AISPTPAGEGKTTVTVGLGQAMSRIGKRAIIALREPSLGPAFGVKGGAAGGGYSQVVPMD
EECCCCCCCCCEEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
EINLHFTGDFHAVTAANNLLAAMIDNHLHQGNKLGLDPRQITFKRVLDMNDRALRSVVIG
CCEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHEE
LGGKNGGVPRQEEFMITPASEVMATLCLAEDLADLKRRCGEIIVGYTYDGAPVRARDLKA
CCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCC
EGAMATLLKEAIKPNLVQTLENTPAFVHGGPFANIAHGCNTVVATRLALKLADYVITEAG
CHHHHHHHHHHHCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGADLGAEKFIDIKCRLSGLRPDAVVVVATIRSLKMHGGLKKDDLAREDLEALQRGSANL
CCCCCCCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
MRHLRNVTEVFGLPAVVAINRFAADTEAEIALLRALVEEAGATAVVADVHARGGDGGIEL
HHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH
AQRVVELVEQPNRFRFAYDDEDSLKTKIEKVATRIYGADGVDFTREASRMLKKLESEGFG
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
RAPVCIAKTQYSFSDDPKKLGAPTGWRLTVREVRPSAGAGFVVALTGEIMTMPGLPPVPA
CCCEEEEEECCCCCCCHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCEEECCCCCCCCC
AESIDVSDDGEITGLF
CCCCCCCCCCCEEECC
>Mature Secondary Structure
MLSDIAIAQRARLEPITKVAEQIGLGPEDLELYGRYKAKVADHVWPRVRSNPDGKLILVT
CCCCHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
AISPTPAGEGKTTVTVGLGQAMSRIGKRAIIALREPSLGPAFGVKGGAAGGGYSQVVPMD
EECCCCCCCCCEEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCC
EINLHFTGDFHAVTAANNLLAAMIDNHLHQGNKLGLDPRQITFKRVLDMNDRALRSVVIG
CCEEEEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHEE
LGGKNGGVPRQEEFMITPASEVMATLCLAEDLADLKRRCGEIIVGYTYDGAPVRARDLKA
CCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHCCC
EGAMATLLKEAIKPNLVQTLENTPAFVHGGPFANIAHGCNTVVATRLALKLADYVITEAG
CHHHHHHHHHHHCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
FGADLGAEKFIDIKCRLSGLRPDAVVVVATIRSLKMHGGLKKDDLAREDLEALQRGSANL
CCCCCCCCCEEEEEEEECCCCCCCEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHH
MRHLRNVTEVFGLPAVVAINRFAADTEAEIALLRALVEEAGATAVVADVHARGGDGGIEL
HHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHH
AQRVVELVEQPNRFRFAYDDEDSLKTKIEKVATRIYGADGVDFTREASRMLKKLESEGFG
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
RAPVCIAKTQYSFSDDPKKLGAPTGWRLTVREVRPSAGAGFVVALTGEIMTMPGLPPVPA
CCCEEEEEECCCCCCCHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCEEECCCCCCCCC
AESIDVSDDGEITGLF
CCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA