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The map label for this gene is cysS

Identifier: 51894254

GI number: 51894254

Start: 3318178

End: 3319593

Strand: Reverse

Name: cysS

Synonym: STH3119

Alternate gene names: 51894254

Gene position: 3319593-3318178 (Counterclockwise)

Preceding gene: 51894255

Following gene: 51894253

Centisome position: 93.09

GC content: 66.67

Gene sequence:

>1416_bases
ATGGGCATCCGCATCTACAATGATCTGACCCGGAAGAAGGAAGACTTCGTCCCTCTCGAACCGGGCAAGGTCCGTTTCTA
CAACTGCGGACCGACCGTCTACGACTACTTTCACATCGGCAACGCCCGCAACTTCGTCGTCTTCGACACGGTTCGACGGT
ACCTGGAGTACCGGGGCTATCAGGTCACCTTCGTTCAGAACTTCACCGACATCGATGACCGCATGATCAAGCGGGCCCGG
GAGCGGGGCATCACCGTCTCCGAGCTGGCCGAGGAGATGATCCAGGCCTACTTTGCCGATGCCGGCGCCCTGGGCGTTCG
CCCCGCGGACGTGCATCCCCGGGCCACCGCGCTCATCGACGAGCAGATCGCCATGATTCAACAGCTCATCGACAAGGGCC
ACGCCTACGTTGTCGAGGGCGGCGACGTGTACTTCCGGGTGACGACAAGCCCCGACTACGGCAAGCTATCCCACAAGAAT
TTGGAGGAACTTGTCGCCGGCGCGTCGGAGCGGGTCGATCCCGACGACCGCAAGGAACACCCCTTCGACTTCGCCCTGTG
GAAGGGGCAGAAGCCCGGGGAGCCCGCCTGGCCGGCCCCGTGGGGCCCCGGCAGGCCTGGCTGGCACATCGAGTGCTCGG
CCATGGCCCGCAAGTACCTGGGCGACACGATCGATATCCACGCCGGGGGCGAGGACCTGACGTTCCCGCACCACGAGAAC
GAGATCGCCCAGTCGGAGGCGGTGACGGGCAAGCCCTTCGCGCGGTACTGGATGCACAACGCCCACCTGATGATCGACGG
CGCCAAGATGTCCAAGTCGGTGGGCAACTTTTTCACGGTGCGGGACATCCTGAAGCGCTACGACGGCGAGGTCGTCCGCA
TGTTCCTCCTGTCGGCGCATTACCGCACGCAGCTCTCCTTCAGCGACCAGCTGATGGAGGACACCAGGCGCGCCCTGGAG
CGGCTGTACAATACCGTGGCGAACCTGGAGCACCTGGCGAAGACGGCCCCGCGCGCGGAGATGACCGCGGAGGAGCAGGC
GGTGCTGGCCGAGCTCTCCCAGGCGCGCGAGCGCTTCGTCGCCGCCATGGACGACGATTTCAACACGGCCGAGGGCCTGG
CCGTCATCTTTGACCTGAGCCGGGAGCTGAACAGCCGGGTGAAGCCCGGCGCCTCCGCGGCCTTCGCCGAGGGCGGGCTG
GCCCTGCTCCGGGAGCTGGCCGGGGTGCTGGGCCTGCTGGAGCGCAAGGCGCAGCCGCAGGAACTGGACGCCGAGATCGA
GGCGCTGATCGCCGCCCGGCAGGAGGCGAGGAAGGCGCGGAACTTTGCCGAGGCCGACCGGATCCGGGATCAGCTTCGCG
CGATGGGCATCATCCTGGAGGACACCCCGCAGGGCGTCCGGTGGCGGCGCGCATGA

Upstream 100 bases:

>100_bases
TTTGACCAGATGCAGCGCCAGATCGACAAGCTGACCCAGCGCATCGAGCGGCTGGAGGAGGAGAACCGGGCGCTGCGCAG
ATTACAGGAGGGTTTGGCGC

Downstream 100 bases:

>100_bases
GGCTGGCCAACCCGCTCACCCTGCCGCCGCTGACCCTGGCCTACCTCGGCGACGCCCTCTACGAGGCGTTCGTGCGGGAG
CGGCTGCTGGAGCGGGGCTA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MGIRIYNDLTRKKEDFVPLEPGKVRFYNCGPTVYDYFHIGNARNFVVFDTVRRYLEYRGYQVTFVQNFTDIDDRMIKRAR
ERGITVSELAEEMIQAYFADAGALGVRPADVHPRATALIDEQIAMIQQLIDKGHAYVVEGGDVYFRVTTSPDYGKLSHKN
LEELVAGASERVDPDDRKEHPFDFALWKGQKPGEPAWPAPWGPGRPGWHIECSAMARKYLGDTIDIHAGGEDLTFPHHEN
EIAQSEAVTGKPFARYWMHNAHLMIDGAKMSKSVGNFFTVRDILKRYDGEVVRMFLLSAHYRTQLSFSDQLMEDTRRALE
RLYNTVANLEHLAKTAPRAEMTAEEQAVLAELSQARERFVAAMDDDFNTAEGLAVIFDLSRELNSRVKPGASAAFAEGGL
ALLRELAGVLGLLERKAQPQELDAEIEALIAARQEARKARNFAEADRIRDQLRAMGIILEDTPQGVRWRRA

Sequences:

>Translated_471_residues
MGIRIYNDLTRKKEDFVPLEPGKVRFYNCGPTVYDYFHIGNARNFVVFDTVRRYLEYRGYQVTFVQNFTDIDDRMIKRAR
ERGITVSELAEEMIQAYFADAGALGVRPADVHPRATALIDEQIAMIQQLIDKGHAYVVEGGDVYFRVTTSPDYGKLSHKN
LEELVAGASERVDPDDRKEHPFDFALWKGQKPGEPAWPAPWGPGRPGWHIECSAMARKYLGDTIDIHAGGEDLTFPHHEN
EIAQSEAVTGKPFARYWMHNAHLMIDGAKMSKSVGNFFTVRDILKRYDGEVVRMFLLSAHYRTQLSFSDQLMEDTRRALE
RLYNTVANLEHLAKTAPRAEMTAEEQAVLAELSQARERFVAAMDDDFNTAEGLAVIFDLSRELNSRVKPGASAAFAEGGL
ALLRELAGVLGLLERKAQPQELDAEIEALIAARQEARKARNFAEADRIRDQLRAMGIILEDTPQGVRWRRA
>Mature_470_residues
GIRIYNDLTRKKEDFVPLEPGKVRFYNCGPTVYDYFHIGNARNFVVFDTVRRYLEYRGYQVTFVQNFTDIDDRMIKRARE
RGITVSELAEEMIQAYFADAGALGVRPADVHPRATALIDEQIAMIQQLIDKGHAYVVEGGDVYFRVTTSPDYGKLSHKNL
EELVAGASERVDPDDRKEHPFDFALWKGQKPGEPAWPAPWGPGRPGWHIECSAMARKYLGDTIDIHAGGEDLTFPHHENE
IAQSEAVTGKPFARYWMHNAHLMIDGAKMSKSVGNFFTVRDILKRYDGEVVRMFLLSAHYRTQLSFSDQLMEDTRRALER
LYNTVANLEHLAKTAPRAEMTAEEQAVLAELSQARERFVAAMDDDFNTAEGLAVIFDLSRELNSRVKPGASAAFAEGGLA
LLRELAGVLGLLERKAQPQELDAEIEALIAARQEARKARNFAEADRIRDQLRAMGIILEDTPQGVRWRRA

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=393, Percent_Identity=39.1857506361323, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI10835051, Length=229, Percent_Identity=44.5414847161572, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI62240992, Length=226, Percent_Identity=45.1327433628319, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI21269877, Length=229, Percent_Identity=44.5414847161572, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI303304987, Length=226, Percent_Identity=45.1327433628319, Blast_Score=200, Evalue=3e-51,
Organism=Escherichia coli, GI1786737, Length=477, Percent_Identity=51.5723270440252, Blast_Score=449, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17509795, Length=250, Percent_Identity=41.2, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17509797, Length=250, Percent_Identity=41.2, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324082, Length=364, Percent_Identity=33.5164835164835, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI19922218, Length=503, Percent_Identity=35.5864811133201, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI19922364, Length=302, Percent_Identity=36.7549668874172, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_SYMTH (Q67JP9)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076945.1
- ProteinModelPortal:   Q67JP9
- SMR:   Q67JP9
- GeneID:   2980287
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3119
- NMPDR:   fig|292459.1.peg.2990
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- BioCyc:   STHE292459:STH3119-MONOMER
- BRENDA:   6.1.1.16
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 53308; Mature: 53177

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIRIYNDLTRKKEDFVPLEPGKVRFYNCGPTVYDYFHIGNARNFVVFDTVRRYLEYRGY
CCEEECCHHHHHHCCCCCCCCCCEEEEECCCCHHHHEEECCCCCEEEHHHHHHHHHHCCC
QVTFVQNFTDIDDRMIKRARERGITVSELAEEMIQAYFADAGALGVRPADVHPRATALID
EEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
EQIAMIQQLIDKGHAYVVEGGDVYFRVTTSPDYGKLSHKNLEELVAGASERVDPDDRKEH
HHHHHHHHHHHCCCEEEEECCEEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCC
PFDFALWKGQKPGEPAWPAPWGPGRPGWHIECSAMARKYLGDTIDIHAGGEDLTFPHHEN
CCCEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCC
EIAQSEAVTGKPFARYWMHNAHLMIDGAKMSKSVGNFFTVRDILKRYDGEVVRMFLLSAH
HHHHHHCCCCCHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHH
YRTQLSFSDQLMEDTRRALERLYNTVANLEHLAKTAPRAEMTAEEQAVLAELSQARERFV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AAMDDDFNTAEGLAVIFDLSRELNSRVKPGASAAFAEGGLALLRELAGVLGLLERKAQPQ
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCH
ELDAEIEALIAARQEARKARNFAEADRIRDQLRAMGIILEDTPQGVRWRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCC
>Mature Secondary Structure 
GIRIYNDLTRKKEDFVPLEPGKVRFYNCGPTVYDYFHIGNARNFVVFDTVRRYLEYRGY
CEEECCHHHHHHCCCCCCCCCCEEEEECCCCHHHHEEECCCCCEEEHHHHHHHHHHCCC
QVTFVQNFTDIDDRMIKRARERGITVSELAEEMIQAYFADAGALGVRPADVHPRATALID
EEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
EQIAMIQQLIDKGHAYVVEGGDVYFRVTTSPDYGKLSHKNLEELVAGASERVDPDDRKEH
HHHHHHHHHHHCCCEEEEECCEEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCC
PFDFALWKGQKPGEPAWPAPWGPGRPGWHIECSAMARKYLGDTIDIHAGGEDLTFPHHEN
CCCEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCCEEEEECCCCCCCCCCCCC
EIAQSEAVTGKPFARYWMHNAHLMIDGAKMSKSVGNFFTVRDILKRYDGEVVRMFLLSAH
HHHHHHCCCCCHHHHHHHCCCEEEEECHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHH
YRTQLSFSDQLMEDTRRALERLYNTVANLEHLAKTAPRAEMTAEEQAVLAELSQARERFV
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AAMDDDFNTAEGLAVIFDLSRELNSRVKPGASAAFAEGGLALLRELAGVLGLLERKAQPQ
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHCCCCH
ELDAEIEALIAARQEARKARNFAEADRIRDQLRAMGIILEDTPQGVRWRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA