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The map label for this gene is lytC [H]

Identifier: 51894175

GI number: 51894175

Start: 3254589

End: 3255353

Strand: Reverse

Name: lytC [H]

Synonym: STH3039

Alternate gene names: 51894175

Gene position: 3255353-3254589 (Counterclockwise)

Preceding gene: 51894176

Following gene: 51894174

Centisome position: 91.29

GC content: 71.37

Gene sequence:

>765_bases
GTGCGCAAGTTTCCGCTGCCTCAGGCCGTCTTGCTGGGCCTGGTCGCCGCCGTCCTGGTCGCGGCGACCTGGCCGCTGTG
GAAAGGGCTGCGGGCGTCCCGGGAGGGCGGCGAGCCGCAGGCCCCCGAACCCGCGCCCGGCCCGCTGGCCGGCTTGGTCA
TCGTGGTGGATCCGGGACACGGGGGCTGGGATCCGGGGGCCGTGGTGGCGGGGGTGAAGGAGAAGGACCTCACGCTGCAG
GTGGCCCACGTCCTCAAGGAGATTTTGGAAGCGCGCGGGGCCCGGGTGGTTCTCACCCGGACCGACGACACCCACTACTC
CCGCACGGTCCGGGAGGACCTGCGTCAGCGGGTGGCCCTGGTGGGCGAGCACCAGGCGGACCTGTTCCTGTCGCTGCACG
CGAATCAGGACCGCTGCCACTGCTGGGGCGCGCAGACCTTCTACCAGAAGGGCGGCTCGGCGGAGGGCAAGGCCCTGGCC
ATCTCCATCCAGAACCGGCTGCGGGAGAGGACCGATACCACCCGATACGCCCTGCCGGGCGACTACTTCGTCCTGCGCAC
CACGGAGGTGCCGGCGGTCATCGTGGAGATGGGCTTCCTCTCCAACGCGGCCGAGCGCGGCCGGATGCAGCAGCCGGAGT
ACCAACGGACGATTGCCGAGGCCATCGCAGACGGGGTCGTGGACTACCGGGAGTACATCTCCCGCCATCCCGGCACGGCG
CCGGAGAATCCGGCTGACCCGGGGGAGGCCTCCCCCCGGTCCTGA

Upstream 100 bases:

>100_bases
GCCACGGGCTTTCTTCATGCGTCCGGAGCCCGCCTGTCCTTCTGCAACCGGCATGTCCGCGCAGGTGGCGCATACCCTTC
CTGCATGAGGGGGGAGGAGT

Downstream 100 bases:

>100_bases
GATTGGGAGCGGGGCGGAGGAATCGCCGGTCGGCGCCTCGAAACCCCTGTAGGAATCGTAGCAGCCAGGGGAGGCGCCGA
CGTTGCACCGTAATCTCAAC

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MRKFPLPQAVLLGLVAAVLVAATWPLWKGLRASREGGEPQAPEPAPGPLAGLVIVVDPGHGGWDPGAVVAGVKEKDLTLQ
VAHVLKEILEARGARVVLTRTDDTHYSRTVREDLRQRVALVGEHQADLFLSLHANQDRCHCWGAQTFYQKGGSAEGKALA
ISIQNRLRERTDTTRYALPGDYFVLRTTEVPAVIVEMGFLSNAAERGRMQQPEYQRTIAEAIADGVVDYREYISRHPGTA
PENPADPGEASPRS

Sequences:

>Translated_254_residues
MRKFPLPQAVLLGLVAAVLVAATWPLWKGLRASREGGEPQAPEPAPGPLAGLVIVVDPGHGGWDPGAVVAGVKEKDLTLQ
VAHVLKEILEARGARVVLTRTDDTHYSRTVREDLRQRVALVGEHQADLFLSLHANQDRCHCWGAQTFYQKGGSAEGKALA
ISIQNRLRERTDTTRYALPGDYFVLRTTEVPAVIVEMGFLSNAAERGRMQQPEYQRTIAEAIADGVVDYREYISRHPGTA
PENPADPGEASPRS
>Mature_254_residues
MRKFPLPQAVLLGLVAAVLVAATWPLWKGLRASREGGEPQAPEPAPGPLAGLVIVVDPGHGGWDPGAVVAGVKEKDLTLQ
VAHVLKEILEARGARVVLTRTDDTHYSRTVREDLRQRVALVGEHQADLFLSLHANQDRCHCWGAQTFYQKGGSAEGKALA
ISIQNRLRERTDTTRYALPGDYFVLRTTEVPAVIVEMGFLSNAAERGRMQQPEYQRTIAEAIADGVVDYREYISRHPGTA
PENPADPGEASPRS

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=271, Percent_Identity=28.0442804428044, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082163, Length=121, Percent_Identity=38.0165289256198, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 27713; Mature: 27713

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFPLPQAVLLGLVAAVLVAATWPLWKGLRASREGGEPQAPEPAPGPLAGLVIVVDPGH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCC
GGWDPGAVVAGVKEKDLTLQVAHVLKEILEARGARVVLTRTDDTHYSRTVREDLRQRVAL
CCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
VGEHQADLFLSLHANQDRCHCWGAQTFYQKGGSAEGKALAISIQNRLRERTDTTRYALPG
HCCCCCEEEEEEECCCCCEEEECHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCEEECCC
DYFVLRTTEVPAVIVEMGFLSNAAERGRMQQPEYQRTIAEAIADGVVDYREYISRHPGTA
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PENPADPGEASPRS
CCCCCCCCCCCCCC
>Mature Secondary Structure
MRKFPLPQAVLLGLVAAVLVAATWPLWKGLRASREGGEPQAPEPAPGPLAGLVIVVDPGH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCC
GGWDPGAVVAGVKEKDLTLQVAHVLKEILEARGARVVLTRTDDTHYSRTVREDLRQRVAL
CCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
VGEHQADLFLSLHANQDRCHCWGAQTFYQKGGSAEGKALAISIQNRLRERTDTTRYALPG
HCCCCCEEEEEEECCCCCEEEECHHHHHHCCCCCCCCEEEEEHHHHHHHHHCCCEEECCC
DYFVLRTTEVPAVIVEMGFLSNAAERGRMQQPEYQRTIAEAIADGVVDYREYISRHPGTA
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PENPADPGEASPRS
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]