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The map label for this gene is argF

Identifier: 51894155

GI number: 51894155

Start: 3238855

End: 3239787

Strand: Reverse

Name: argF

Synonym: STH3019

Alternate gene names: 51894155

Gene position: 3239787-3238855 (Counterclockwise)

Preceding gene: 51894156

Following gene: 51894153

Centisome position: 90.85

GC content: 68.92

Gene sequence:

>933_bases
GTGACGACCCTCAAAGGGAGGGATTTCATCTCGCTCCACGACTGGAGCAGGGACGAGCTGGAAGAGGTGCTGGAGCTGGC
GATGTGGCAGAAGGCCCGCCTGAAGGCGGGCATTCGCGACGAGCCGCTGAAGGGGAAGCAACTCGGGATGTACTTTGCCA
AGCCCTCGACCCGCACGCGGCTCTCCTTCGAGGTCGGCATCCGCCAACTCGGGGGCGATGCCCTGTTCCTCTCGGCGCAC
GACCTGCAGCTGCAGCGCGGCGAATCCATCGCCGATACCGCCCGGGTGATGAGCCGGTTCCTCGACGGCATCATGATCCG
TACCTTCTCCCACCGGGAGGTGGTGGAGCTGGCCGAGTGGGCGACGATCCCCGTCATCAACGGCCTGACCGACGAGGAGC
ACCCGTGCCAGGTGGTGGCCGACCTGCTCACGGCCCTGGAACGGTTCGGCACGCTGCCGGGGCTCAAGCTGGCCTACGTG
GGGGACGGCAACAACGTGGCCCACAGCCTGATGGACGGCGGCGCGAAGTTTGGTATGCACGTCGTGGTCGCCAGCCCCGA
GGGCTACCAGCCCGATCCCGCGCGGGTCGCCCGGGCGCAGGTGACGGCGGCGCGGTACGGCGGCCTGGTCGAGGTCGTGA
CCGACCCGGTCCTGGCGGTGACCGGCGCCCAGATCGTGTACACGGACGTATGGGCCAGCATGGGCCAGGAGGCTGAGGCC
GAGCAGCGGAGGAAGGCGTTCGCCGGCTACCAGGTGACGGCGGAGCTCATGCGGTGCGCGGCGCCCGAGGCGATCTTCAT
GCACTGCCTCCCGGCCCACCGGGGCGAGGAGGTGGCCGCCGAGGTGATCGACGGCCCGCAGTCCGCGGTGTTCGACGAGG
CCGAGAACCGGCTGCACGCGCAGAAGGCGATCATGACGTTGATCATGGCCTGA

Upstream 100 bases:

>100_bases
CCGCACTAGGGCGGCGGGGCGTGCATTTTTATGCTTGCGCTCTGCATAGATATGCGTTACACTCTTTCCTATCCAGGGAA
GGAGGACGCGTGTCGTGACG

Downstream 100 bases:

>100_bases
GCAGCCCGGGTAGGAGAGAAAAAGAAGCAGCCAGCACGGCGATCGTGCTGGCTGCTTTTCCACTCTGTGGTTAGGCTGTG
GCCTTTGCCGTGGCGGTCTC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTTLKGRDFISLHDWSRDELEEVLELAMWQKARLKAGIRDEPLKGKQLGMYFAKPSTRTRLSFEVGIRQLGGDALFLSAH
DLQLQRGESIADTARVMSRFLDGIMIRTFSHREVVELAEWATIPVINGLTDEEHPCQVVADLLTALERFGTLPGLKLAYV
GDGNNVAHSLMDGGAKFGMHVVVASPEGYQPDPARVARAQVTAARYGGLVEVVTDPVLAVTGAQIVYTDVWASMGQEAEA
EQRRKAFAGYQVTAELMRCAAPEAIFMHCLPAHRGEEVAAEVIDGPQSAVFDEAENRLHAQKAIMTLIMA

Sequences:

>Translated_310_residues
MTTLKGRDFISLHDWSRDELEEVLELAMWQKARLKAGIRDEPLKGKQLGMYFAKPSTRTRLSFEVGIRQLGGDALFLSAH
DLQLQRGESIADTARVMSRFLDGIMIRTFSHREVVELAEWATIPVINGLTDEEHPCQVVADLLTALERFGTLPGLKLAYV
GDGNNVAHSLMDGGAKFGMHVVVASPEGYQPDPARVARAQVTAARYGGLVEVVTDPVLAVTGAQIVYTDVWASMGQEAEA
EQRRKAFAGYQVTAELMRCAAPEAIFMHCLPAHRGEEVAAEVIDGPQSAVFDEAENRLHAQKAIMTLIMA
>Mature_309_residues
TTLKGRDFISLHDWSRDELEEVLELAMWQKARLKAGIRDEPLKGKQLGMYFAKPSTRTRLSFEVGIRQLGGDALFLSAHD
LQLQRGESIADTARVMSRFLDGIMIRTFSHREVVELAEWATIPVINGLTDEEHPCQVVADLLTALERFGTLPGLKLAYVG
DGNNVAHSLMDGGAKFGMHVVVASPEGYQPDPARVARAQVTAARYGGLVEVVTDPVLAVTGAQIVYTDVWASMGQEAEAE
QRRKAFAGYQVTAELMRCAAPEAIFMHCLPAHRGEEVAAEVIDGPQSAVFDEAENRLHAQKAIMTLIMA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=308, Percent_Identity=44.1558441558442, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI18105007, Length=316, Percent_Identity=27.8481012658228, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1790703, Length=336, Percent_Identity=38.0952380952381, Blast_Score=212, Evalue=3e-56,
Organism=Escherichia coli, GI1786469, Length=331, Percent_Identity=38.0664652567976, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI2367364, Length=318, Percent_Identity=29.874213836478, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI48994908, Length=316, Percent_Identity=29.4303797468354, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193204318, Length=333, Percent_Identity=25.5255255255255, Blast_Score=86, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322373, Length=309, Percent_Identity=36.5695792880259, Blast_Score=206, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6322331, Length=319, Percent_Identity=26.9592476489028, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24642586, Length=319, Percent_Identity=28.5266457680251, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_SYMTH (Q67JZ8)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076846.1
- ProteinModelPortal:   Q67JZ8
- SMR:   Q67JZ8
- GeneID:   2982153
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3019
- NMPDR:   fig|292459.1.peg.2891
- HOGENOM:   HBG579429
- OMA:   GATIHIS
- BioCyc:   STHE292459:STH3019-MONOMER
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34016; Mature: 33885

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 107-107 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLKGRDFISLHDWSRDELEEVLELAMWQKARLKAGIRDEPLKGKQLGMYFAKPSTRTR
CCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCE
LSFEVGIRQLGGDALFLSAHDLQLQRGESIADTARVMSRFLDGIMIRTFSHREVVELAEW
EEHHHHHHHHCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHH
ATIPVINGLTDEEHPCQVVADLLTALERFGTLPGLKLAYVGDGNNVAHSLMDGGAKFGMH
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCEE
VVVASPEGYQPDPARVARAQVTAARYGGLVEVVTDPVLAVTGAQIVYTDVWASMGQEAEA
EEEECCCCCCCCHHHHHHHHHHHHHHCCEEEHHHCCHHHHCCCHHHHHHHHHHCCCCHHH
EQRRKAFAGYQVTAELMRCAAPEAIFMHCLPAHRGEEVAAEVIDGPQSAVFDEAENRLHA
HHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
QKAIMTLIMA
HHHHHHHHCC
>Mature Secondary Structure 
TTLKGRDFISLHDWSRDELEEVLELAMWQKARLKAGIRDEPLKGKQLGMYFAKPSTRTR
CCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCE
LSFEVGIRQLGGDALFLSAHDLQLQRGESIADTARVMSRFLDGIMIRTFSHREVVELAEW
EEHHHHHHHHCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCHHHHHHHHH
ATIPVINGLTDEEHPCQVVADLLTALERFGTLPGLKLAYVGDGNNVAHSLMDGGAKFGMH
HHCCEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCCCCEE
VVVASPEGYQPDPARVARAQVTAARYGGLVEVVTDPVLAVTGAQIVYTDVWASMGQEAEA
EEEECCCCCCCCHHHHHHHHHHHHHHCCEEEHHHCCHHHHCCCHHHHHHHHHHCCCCHHH
EQRRKAFAGYQVTAELMRCAAPEAIFMHCLPAHRGEEVAAEVIDGPQSAVFDEAENRLHA
HHHHHHHCCHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHH
QKAIMTLIMA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA