Click here to switch to the map view.

The map label for this gene is argC

Identifier: 51894028

GI number: 51894028

Start: 3115731

End: 3116777

Strand: Reverse

Name: argC

Synonym: STH2892

Alternate gene names: 51894028

Gene position: 3116777-3115731 (Counterclockwise)

Preceding gene: 51894029

Following gene: 51894027

Centisome position: 87.4

GC content: 69.82

Gene sequence:

>1047_bases
ATGACGATACGCGTGGGAATCGCCGGAGCCACCGGCTATACCGGCGTGGAACTGGTCCGGCTGCTGGCGCAGCACCCGGA
GGCGGAGGTGGTGGTGGCCGGCACCGAGAGCTACCAGGGACAGCACCTCGCCGCGGTCTACCCCCACCTGCGGGAGCGGG
TGGACCTGGTCGGACGGGAAGCCTCGCCCGAGGCCCTGGCGGGGTGCGACGTGGTGTTCACCTCCCTGCCCCACGGCCTG
ACCATGGCCCTGGCGCCGGCGGTGCTCGCGGCCGGCGGGCGGCTGATCGACCTGGGGGCCGACTTCCGGCTGCGGGACGT
GACCGCATACGAGCAGTGGTACCGAAAGACCCACACCGCCCCGGACCTCATGGAAGAGGCGGTGTACGGCCTGCCGGAGC
TTTACCGGGAGCGGATCCGGGGGGCGCGGCTGGTCGGGAACCCCGGCTGTTACCCCACGGCCTGTGCGCTCGCAGCCGCG
CCGCTGCTTCAGGCCGGCGTGGTGGAGACGGAGGGGATCATCTTTGACGCCAAGTCCGGCGTGTCCGGCGCCGGGCGCGG
GGTCAACCTCGGCGTCCACTTCTCAGAAGTCAACGAGAACTTCAAGGCCTACAACATCGCCGGGACCCACCGGCACACGC
CCGAGATCGAGCAGACCCTCTCGGACCTGGCCGGCCGGCCCGTGGTGGTGAGCTTCACGCCGCACCTGGTGCCCATGACC
CGGGGGATCCTCGCCACCGGGTACTTCACACTGAAGGCGGAGCGTACCACCGAGCAGCTGGTGGACCTGTTCCGGGAGTT
CTACGCCGGGGAGCCCTTCGTCCGGGTGCGCCCGGCGGGCGAACTGCCCACCACCAAACAGGTCTGGGGTTCCAACTACT
GCGACATCGGCCTGCAGGTGGACCCGCGCACCCGCCGGGTGCTGGTCATCAGCGTCATCGACAACCTGGTCAAGGGCGCG
GCGGGCCAGGCGATCCAGAACATGAACCTGCTCTTCGGCCTTCCCGAGACCACGGGACTGCTGAACGCCGGACCGGTCTA
CCCTTGA

Upstream 100 bases:

>100_bases
TGATGAAGAGGTCCGGGCCCGTGAGCGGGCTCCGGGGATTGCATCTTTATACACTTAGAGTTATGATTATGCAACAAGAA
CAGGGGCGGAGGCCGGAACG

Downstream 100 bases:

>100_bases
ACCGGCCGGTCCCATCCATCTGCCCAGGAGGGATCACATGCTGTTTCGGAAGGCCGTGATGGCCGACATCCCGGCGGCCC
ACGAGATCATCAACGGTTAC

Product: putative N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MTIRVGIAGATGYTGVELVRLLAQHPEAEVVVAGTESYQGQHLAAVYPHLRERVDLVGREASPEALAGCDVVFTSLPHGL
TMALAPAVLAAGGRLIDLGADFRLRDVTAYEQWYRKTHTAPDLMEEAVYGLPELYRERIRGARLVGNPGCYPTACALAAA
PLLQAGVVETEGIIFDAKSGVSGAGRGVNLGVHFSEVNENFKAYNIAGTHRHTPEIEQTLSDLAGRPVVVSFTPHLVPMT
RGILATGYFTLKAERTTEQLVDLFREFYAGEPFVRVRPAGELPTTKQVWGSNYCDIGLQVDPRTRRVLVISVIDNLVKGA
AGQAIQNMNLLFGLPETTGLLNAGPVYP

Sequences:

>Translated_348_residues
MTIRVGIAGATGYTGVELVRLLAQHPEAEVVVAGTESYQGQHLAAVYPHLRERVDLVGREASPEALAGCDVVFTSLPHGL
TMALAPAVLAAGGRLIDLGADFRLRDVTAYEQWYRKTHTAPDLMEEAVYGLPELYRERIRGARLVGNPGCYPTACALAAA
PLLQAGVVETEGIIFDAKSGVSGAGRGVNLGVHFSEVNENFKAYNIAGTHRHTPEIEQTLSDLAGRPVVVSFTPHLVPMT
RGILATGYFTLKAERTTEQLVDLFREFYAGEPFVRVRPAGELPTTKQVWGSNYCDIGLQVDPRTRRVLVISVIDNLVKGA
AGQAIQNMNLLFGLPETTGLLNAGPVYP
>Mature_347_residues
TIRVGIAGATGYTGVELVRLLAQHPEAEVVVAGTESYQGQHLAAVYPHLRERVDLVGREASPEALAGCDVVFTSLPHGLT
MALAPAVLAAGGRLIDLGADFRLRDVTAYEQWYRKTHTAPDLMEEAVYGLPELYRERIRGARLVGNPGCYPTACALAAAP
LLQAGVVETEGIIFDAKSGVSGAGRGVNLGVHFSEVNENFKAYNIAGTHRHTPEIEQTLSDLAGRPVVVSFTPHLVPMTR
GILATGYFTLKAERTTEQLVDLFREFYAGEPFVRVRPAGELPTTKQVWGSNYCDIGLQVDPRTRRVLVISVIDNLVKGAA
GQAIQNMNLLFGLPETTGLLNAGPVYP

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=341, Percent_Identity=39.0029325513196, Blast_Score=204, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6320913, Length=350, Percent_Identity=29.7142857142857, Blast_Score=105, Evalue=9e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_SYMTH (Q67KC3)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076719.1
- HSSP:   Q9X2A2
- ProteinModelPortal:   Q67KC3
- SMR:   Q67KC3
- GeneID:   2982215
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2892
- NMPDR:   fig|292459.1.peg.2767
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- BioCyc:   STHE292459:STH2892-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 37486; Mature: 37355

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS01224 ARGC

Important sites: ACT_SITE 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIRVGIAGATGYTGVELVRLLAQHPEAEVVVAGTESYQGQHLAAVYPHLRERVDLVGRE
CEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
ASPEALAGCDVVFTSLPHGLTMALAPAVLAAGGRLIDLGADFRLRDVTAYEQWYRKTHTA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHHHCCC
PDLMEEAVYGLPELYRERIRGARLVGNPGCYPTACALAAAPLLQAGVVETEGIIFDAKSG
HHHHHHHHHCCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCEECCCEEEECCCC
VSGAGRGVNLGVHFSEVNENFKAYNIAGTHRHTPEIEQTLSDLAGRPVVVSFTPHLVPMT
CCCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHH
RGILATGYFTLKAERTTEQLVDLFREFYAGEPFVRVRPAGELPTTKQVWGSNYCDIGLQV
HHHHEECEEEEEECHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCEEEEEEE
DPRTRRVLVISVIDNLVKGAAGQAIQNMNLLFGLPETTGLLNAGPVYP
CCCCCEEEEHHHHHHHHHCHHHHHHHCCCEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TIRVGIAGATGYTGVELVRLLAQHPEAEVVVAGTESYQGQHLAAVYPHLRERVDLVGRE
EEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
ASPEALAGCDVVFTSLPHGLTMALAPAVLAAGGRLIDLGADFRLRDVTAYEQWYRKTHTA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCEEEHHHHHHHHHHHHCCC
PDLMEEAVYGLPELYRERIRGARLVGNPGCYPTACALAAAPLLQAGVVETEGIIFDAKSG
HHHHHHHHHCCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCEECCCEEEECCCC
VSGAGRGVNLGVHFSEVNENFKAYNIAGTHRHTPEIEQTLSDLAGRPVVVSFTPHLVPMT
CCCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHH
RGILATGYFTLKAERTTEQLVDLFREFYAGEPFVRVRPAGELPTTKQVWGSNYCDIGLQV
HHHHEECEEEEEECHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCEEEEEEE
DPRTRRVLVISVIDNLVKGAAGQAIQNMNLLFGLPETTGLLNAGPVYP
CCCCCEEEEHHHHHHHHHCHHHHHHHCCCEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA