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The map label for this gene is vanS [H]

Identifier: 51893643

GI number: 51893643

Start: 2690262

End: 2691413

Strand: Reverse

Name: vanS [H]

Synonym: STH2505

Alternate gene names: 51893643

Gene position: 2691413-2690262 (Counterclockwise)

Preceding gene: 51893644

Following gene: 51893641

Centisome position: 75.47

GC content: 69.36

Gene sequence:

>1152_bases
TTGAGAAGTAACCTGGCGTTCAGCCTCCGCTGGCGGATGATCCTGACGTTCATGGCGAGCGGTTTCCTGGCGGCGGTGTC
GACGGCGCTGATGCTGGCGGTGGCCGCCAACCTGGCCGGCTCGATTCCGCCGTTCAACTGGCTCCTGAACTTCCTGGCCG
ACACGGTCGGCGTCTGGCCGATCGTGTTCGCGGTCGCCGTCGTGCTCTCGTTCACCTGGTACATCCTGCTCAGCCAGCCG
ATGATCCGCTACCTCGAGGCCCTGAGCCGGGCGATGGACGAGGTGGCCCGGGGCAACTACGACGTCACCGTCCCGCCCCG
CGGGCGCGATGAGCTGGGGCTGCTGGGGGAGAACCTGGTGTCCATGAGCCGGCAGATCAAGGCCTCCCTGCAGCGGGAGC
GGCAAGCCAACCAGGCCCGGTACGAGCTGATCACGGCCGTCTCCCACGACCTCCGGACCCCGCTCACCTCCGTGCTGGGG
TACCTGCAGCTGATTGACGAGGACCGGTACCGGGACGAGGTGGAGCTTCGCTACTACGTGGACATGGCCTACGAGAAGGC
GAAGCAGCTGAAGCGGCTCATCGACCAGCTCTTCGAGTTCACCCGCACCAGCCACGGGGGCATCGTCCTGCGGCCGGTGC
CCATCAACCCGGCGGAGCTGCTGGAGCAGGTGGCGGAGGCGTTTGTGCCCGCCCTACAGGAGGCGGGCATGGAGTACCGG
CTGCGGCTGCCCGACGAGCGGGCGACGGTCCTGGCCGACCCCGACCTGCTGGTGCGGGTGCTGGAGAACCTGATCTCCAA
CGCGATCCGCTACGGCCGGGAGGGCAAGGTGGTGGAGCTGGAGCTGGAGGTGCGGCGGGTGGAGCGGGCGGTGCTGCTGC
GCGTCGCCAACCGGGGCAACCCCATCCCGTCTCACCAGCTGGACCGGATCTTCGACTCCTTCTACCGGGGCGAGGTCTCC
CGGTCGGGCCGCACCGGCGGCGCGGGGCTGGGGCTGGCCATCGTCCGGAACATCGTCACGCTCCACGGCGGCACGGTCCG
GGCCATCAACGAGACGGATCGCACCGTGTTCGAGGTGAGGCTGCCGGCGGCGGGGGGCGCCGAAGCCGCCGGAGCCGGCC
TCAGCCCAGGTGCGGCGGTACGTACAGATTGA

Upstream 100 bases:

>100_bases
AACACGGTGATGGTCCACATCCGCCGGCTGCGGGAGAAGGTGGAGGACGACCCCAGCCATCCCACGCTCATCCGGACCGT
CTGGGGGGTCGGCTACAAGA

Downstream 100 bases:

>100_bases
GGAACACAGGGACGGCCAGGTTGCCCAGGTCGACGAGGACGTGGGAGGCCACAGCCCACCGGAGCGTTCCCGTCCGGCGG
TAGGCGGCCGCCCAGGCCAG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: Vancomycin histidine protein kinase; Vancomycin resistance protein vanS [H]

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MRSNLAFSLRWRMILTFMASGFLAAVSTALMLAVAANLAGSIPPFNWLLNFLADTVGVWPIVFAVAVVLSFTWYILLSQP
MIRYLEALSRAMDEVARGNYDVTVPPRGRDELGLLGENLVSMSRQIKASLQRERQANQARYELITAVSHDLRTPLTSVLG
YLQLIDEDRYRDEVELRYYVDMAYEKAKQLKRLIDQLFEFTRTSHGGIVLRPVPINPAELLEQVAEAFVPALQEAGMEYR
LRLPDERATVLADPDLLVRVLENLISNAIRYGREGKVVELELEVRRVERAVLLRVANRGNPIPSHQLDRIFDSFYRGEVS
RSGRTGGAGLGLAIVRNIVTLHGGTVRAINETDRTVFEVRLPAAGGAEAAGAGLSPGAAVRTD

Sequences:

>Translated_383_residues
MRSNLAFSLRWRMILTFMASGFLAAVSTALMLAVAANLAGSIPPFNWLLNFLADTVGVWPIVFAVAVVLSFTWYILLSQP
MIRYLEALSRAMDEVARGNYDVTVPPRGRDELGLLGENLVSMSRQIKASLQRERQANQARYELITAVSHDLRTPLTSVLG
YLQLIDEDRYRDEVELRYYVDMAYEKAKQLKRLIDQLFEFTRTSHGGIVLRPVPINPAELLEQVAEAFVPALQEAGMEYR
LRLPDERATVLADPDLLVRVLENLISNAIRYGREGKVVELELEVRRVERAVLLRVANRGNPIPSHQLDRIFDSFYRGEVS
RSGRTGGAGLGLAIVRNIVTLHGGTVRAINETDRTVFEVRLPAAGGAEAAGAGLSPGAAVRTD
>Mature_383_residues
MRSNLAFSLRWRMILTFMASGFLAAVSTALMLAVAANLAGSIPPFNWLLNFLADTVGVWPIVFAVAVVLSFTWYILLSQP
MIRYLEALSRAMDEVARGNYDVTVPPRGRDELGLLGENLVSMSRQIKASLQRERQANQARYELITAVSHDLRTPLTSVLG
YLQLIDEDRYRDEVELRYYVDMAYEKAKQLKRLIDQLFEFTRTSHGGIVLRPVPINPAELLEQVAEAFVPALQEAGMEYR
LRLPDERATVLADPDLLVRVLENLISNAIRYGREGKVVELELEVRRVERAVLLRVANRGNPIPSHQLDRIFDSFYRGEVS
RSGRTGGAGLGLAIVRNIVTLHGGTVRAINETDRTVFEVRLPAAGGAEAAGAGLSPGAAVRTD

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=255, Percent_Identity=30.5882352941176, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786783, Length=355, Percent_Identity=27.6056338028169, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1786912, Length=260, Percent_Identity=31.1538461538462, Blast_Score=101, Evalue=7e-23,
Organism=Escherichia coli, GI145693157, Length=258, Percent_Identity=26.7441860465116, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87082128, Length=317, Percent_Identity=27.1293375394322, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789149, Length=332, Percent_Identity=22.5903614457831, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=28.5123966942149, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=29.3918918918919, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786600, Length=209, Percent_Identity=28.7081339712919, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87081816, Length=296, Percent_Identity=27.7027027027027, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=306, Percent_Identity=25.1633986928105, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=26.4150943396226, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=211, Percent_Identity=27.4881516587678, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=269, Percent_Identity=27.1375464684015, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787894, Length=292, Percent_Identity=27.7397260273973, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787374, Length=335, Percent_Identity=23.2835820895522, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789808, Length=264, Percent_Identity=27.6515151515151, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790551, Length=210, Percent_Identity=30, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42560; Mature: 42560

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSNLAFSLRWRMILTFMASGFLAAVSTALMLAVAANLAGSIPPFNWLLNFLADTVGVWP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IVFAVAVVLSFTWYILLSQPMIRYLEALSRAMDEVARGNYDVTVPPRGRDELGLLGENLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHH
SMSRQIKASLQRERQANQARYELITAVSHDLRTPLTSVLGYLQLIDEDRYRDEVELRYYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHH
DMAYEKAKQLKRLIDQLFEFTRTSHGGIVLRPVPINPAELLEQVAEAFVPALQEAGMEYR
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEE
LRLPDERATVLADPDLLVRVLENLISNAIRYGREGKVVELELEVRRVERAVLLRVANRGN
EECCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCC
PIPSHQLDRIFDSFYRGEVSRSGRTGGAGLGLAIVRNIVTLHGGTVRAINETDRTVFEVR
CCCCHHHHHHHHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEE
LPAAGGAEAAGAGLSPGAAVRTD
CCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRSNLAFSLRWRMILTFMASGFLAAVSTALMLAVAANLAGSIPPFNWLLNFLADTVGVWP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
IVFAVAVVLSFTWYILLSQPMIRYLEALSRAMDEVARGNYDVTVPPRGRDELGLLGENLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHH
SMSRQIKASLQRERQANQARYELITAVSHDLRTPLTSVLGYLQLIDEDRYRDEVELRYYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHHHH
DMAYEKAKQLKRLIDQLFEFTRTSHGGIVLRPVPINPAELLEQVAEAFVPALQEAGMEYR
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEE
LRLPDERATVLADPDLLVRVLENLISNAIRYGREGKVVELELEVRRVERAVLLRVANRGN
EECCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCC
PIPSHQLDRIFDSFYRGEVSRSGRTGGAGLGLAIVRNIVTLHGGTVRAINETDRTVFEVR
CCCCHHHHHHHHHHHHCHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEE
LPAAGGAEAAGAGLSPGAAVRTD
CCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077 [H]