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The map label for this gene is relA [H]

Identifier: 51893575

GI number: 51893575

Start: 2620432

End: 2622639

Strand: Reverse

Name: relA [H]

Synonym: STH2437

Alternate gene names: 51893575

Gene position: 2622639-2620432 (Counterclockwise)

Preceding gene: 51893576

Following gene: 51893573

Centisome position: 73.54

GC content: 65.44

Gene sequence:

>2208_bases
GTGACAGCCGTGATCGATATCCAACCGCTCTTGGATAAGGTGCGCTCGTACAACCCGACCGCGGATGTCGCCCTGATTGA
CAACGCCTTCGCGTTCGCCAAGCAGGCGCATGAAGGCCAGTGCCGACGATCGGGGGAGCCGTATATCACGCACCCGATCG
CCGTTGCCGAAATCGTGGCCTCGCTGGAGCTGGATGAGGAGTCCATCGCCGCCGCCCTCCTGCACGACGTGCTGGAGGAC
TGCGGCGTGAAGTACGAGGAGCTGGAGGAGCGGTTCGGCAAGGAGGTCGCCACGCTGGTGGACGGGGTCTCCAAGCTGGA
CCGGCTCCAGTTCACGTCGCGCGACGAGGCGCAGGTGGAGAACCTGCGCAAGATGTTTCTCGCGATGGCCAAGGACCTGC
GCGTCATCCTGATCAAGCTGGCGGACCGGCTGCACAACATGCGCACGCTGAAGCACCAGCCGTCGGACGCGCAGGTGCGC
ATCGCGCAGGAGACGATGGACATCTACGCGCCGCTGGCCCACCGGCTGGGGCTCAGCGAGATCAAGTGGGAGCTGGAGGA
CCTCGCCTTCCGCATCCTGGAGCCCGACCGCTACCAGGAGATGGCCTACCTGGTGGCCCGCAAGCGGCAGGAGCGGATGG
CCATCACCCAGGACCTGATGGACCAGCTGCGGGAGGTGCTGGAGAAGGAAGGGATCCAGGCGGAGATCTCCGGCCGCCCG
AAGCACTTCTACTCCATCTACAAGAAGATGTACCGGCAGGGCAAGGACATCTCGCAGATCTACGACCTCATCGCGATCCG
GATCATCGTGGAGGAGGTCAAGGACTGCTATGCCGTGCTGGGCATCATCCACAGCCACTGGAAGCCGCTGCCGCTCCGGT
TCAAGGACTATATCGCCACGCCCAAGCCCAACATGTACCAGTCGCTGCACACGACGGTAATCGGGCCGCACGGCGAGCCC
TTTGAGATCCAGATCCGCACCCGCGAAATGCACCGCACCGCCGAGTTCGGCGTGGCGGCCCACTGGTCGTACAAGGAAGG
CAAGACCGACAAGGAGTTCGACCGGAAGCTGCAGTGGCTGCGGTCGCTGCTGGAGTGGCACCAGGAGATCCGCGACGCCC
GGGAGTTCGTCGAGTCGGTCAAGGTGGACATCTTCTCCGACCAGGTCTTCGTCTTCTCCCCCAAGGGGCACGTGTTCAGC
CTGCCTGCGGGCGGCACGCCCCTGGACTTCGCCTTCGCCGTCCACTCCGACATCGGGTACCGGTGCGTCGGGGCCAAGGT
CAACGGCAAGATCGCGCCGCTGGACACGGCGCTGAAGAACGGCGACGTGGTGGAGATCCTGACCTCCAAGCAGTCGCCGG
GCCCCTCCATCGACTGGCTGAAGATCGTCAAGACCGCCTCGGCCAAGAACAAGATCCGCCAGTTCTTCAAGCGGGAGCGC
CGGGAGGAGAACCTGGCCCGGGGCAAGGAGATCCTGAAGGGCGAGGTACAGAAGACCGGCATCGAGCCGCACGAGCTGAT
GCGGGACGAGTGGATGGCCGAGGTCTGCCGGAAGGTCAGCGTCAAGGACGTGGACGACCTCTACGTGGCCATCGGCATCG
GCTCGCTGAACGCCGCCTCCGTGGTCTCCCGGCTGCGGGAGATGTACGAGAAGGAGAAGCGGGCCCAGGAGCCGGCCGCG
CCCGTCGAGATCGAGAAGAAGGACTGGTCCGGTTACGGCAAGGCCTCCAACGGCATCCGGGTCAAAGGCGTGTCCAACCT
GGTGGTGCGGCTCTCCCGGTGCTGTACCCCCGTCCCCGGCGACCCGATCATCGGTTACGTCACCCGCGGCCGCGGGGTCA
CGGTGCACCGCATCGACTGCCCCAATATGGAGGACCTGGCCAAGGACCCCGACCGGCTGATCGAGGTGGCCTGGGAGGAG
AACTACCAGACCACCGCCCCGGTGGAGGTGCAGGTGACGGCCCTCGACCGCTCCGGGCTGCTGGCGGACGTGGTCTCCAT
CATCGCCGACGCCCGGATCAACATGCTCTCCACGTCCAGCCGGGCGAACAAGTCGAAGATCGCCACGTTGGACCTGGTGT
TGGAGATCCGCGACGCGCAGCAGCTGCAGTACGTGATGAACAAGATCGGCAAGGTCCGAGACGTCATGCACGTCGAGCGC
GTGGTGCGGGAGCGGCGCGGGAAGGCTGCGCGGGCCAAGCAGGCGTGA

Upstream 100 bases:

>100_bases
TGATCGAGCTCTCGGACCTCGGCGGCAGGAAGCGGTTGGAAGGCCACGATGTGATTTCGCTGGTCCAGTTCTGAGAACCG
ACGACAGGCGGGACAGGGGG

Downstream 100 bases:

>100_bases
CGTGTCTCCCCCAAGACCAGGCCACAGAACAACGCCGACGCAGAACGCGCCGGCGTCTTTACCTTTCTTGCCTCCGTCAG
AGGGCGATCATCAGCCCGAA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 735; Mature: 734

Protein sequence:

>735_residues
MTAVIDIQPLLDKVRSYNPTADVALIDNAFAFAKQAHEGQCRRSGEPYITHPIAVAEIVASLELDEESIAAALLHDVLED
CGVKYEELEERFGKEVATLVDGVSKLDRLQFTSRDEAQVENLRKMFLAMAKDLRVILIKLADRLHNMRTLKHQPSDAQVR
IAQETMDIYAPLAHRLGLSEIKWELEDLAFRILEPDRYQEMAYLVARKRQERMAITQDLMDQLREVLEKEGIQAEISGRP
KHFYSIYKKMYRQGKDISQIYDLIAIRIIVEEVKDCYAVLGIIHSHWKPLPLRFKDYIATPKPNMYQSLHTTVIGPHGEP
FEIQIRTREMHRTAEFGVAAHWSYKEGKTDKEFDRKLQWLRSLLEWHQEIRDAREFVESVKVDIFSDQVFVFSPKGHVFS
LPAGGTPLDFAFAVHSDIGYRCVGAKVNGKIAPLDTALKNGDVVEILTSKQSPGPSIDWLKIVKTASAKNKIRQFFKRER
REENLARGKEILKGEVQKTGIEPHELMRDEWMAEVCRKVSVKDVDDLYVAIGIGSLNAASVVSRLREMYEKEKRAQEPAA
PVEIEKKDWSGYGKASNGIRVKGVSNLVVRLSRCCTPVPGDPIIGYVTRGRGVTVHRIDCPNMEDLAKDPDRLIEVAWEE
NYQTTAPVEVQVTALDRSGLLADVVSIIADARINMLSTSSRANKSKIATLDLVLEIRDAQQLQYVMNKIGKVRDVMHVER
VVRERRGKAARAKQA

Sequences:

>Translated_735_residues
MTAVIDIQPLLDKVRSYNPTADVALIDNAFAFAKQAHEGQCRRSGEPYITHPIAVAEIVASLELDEESIAAALLHDVLED
CGVKYEELEERFGKEVATLVDGVSKLDRLQFTSRDEAQVENLRKMFLAMAKDLRVILIKLADRLHNMRTLKHQPSDAQVR
IAQETMDIYAPLAHRLGLSEIKWELEDLAFRILEPDRYQEMAYLVARKRQERMAITQDLMDQLREVLEKEGIQAEISGRP
KHFYSIYKKMYRQGKDISQIYDLIAIRIIVEEVKDCYAVLGIIHSHWKPLPLRFKDYIATPKPNMYQSLHTTVIGPHGEP
FEIQIRTREMHRTAEFGVAAHWSYKEGKTDKEFDRKLQWLRSLLEWHQEIRDAREFVESVKVDIFSDQVFVFSPKGHVFS
LPAGGTPLDFAFAVHSDIGYRCVGAKVNGKIAPLDTALKNGDVVEILTSKQSPGPSIDWLKIVKTASAKNKIRQFFKRER
REENLARGKEILKGEVQKTGIEPHELMRDEWMAEVCRKVSVKDVDDLYVAIGIGSLNAASVVSRLREMYEKEKRAQEPAA
PVEIEKKDWSGYGKASNGIRVKGVSNLVVRLSRCCTPVPGDPIIGYVTRGRGVTVHRIDCPNMEDLAKDPDRLIEVAWEE
NYQTTAPVEVQVTALDRSGLLADVVSIIADARINMLSTSSRANKSKIATLDLVLEIRDAQQLQYVMNKIGKVRDVMHVER
VVRERRGKAARAKQA
>Mature_734_residues
TAVIDIQPLLDKVRSYNPTADVALIDNAFAFAKQAHEGQCRRSGEPYITHPIAVAEIVASLELDEESIAAALLHDVLEDC
GVKYEELEERFGKEVATLVDGVSKLDRLQFTSRDEAQVENLRKMFLAMAKDLRVILIKLADRLHNMRTLKHQPSDAQVRI
AQETMDIYAPLAHRLGLSEIKWELEDLAFRILEPDRYQEMAYLVARKRQERMAITQDLMDQLREVLEKEGIQAEISGRPK
HFYSIYKKMYRQGKDISQIYDLIAIRIIVEEVKDCYAVLGIIHSHWKPLPLRFKDYIATPKPNMYQSLHTTVIGPHGEPF
EIQIRTREMHRTAEFGVAAHWSYKEGKTDKEFDRKLQWLRSLLEWHQEIRDAREFVESVKVDIFSDQVFVFSPKGHVFSL
PAGGTPLDFAFAVHSDIGYRCVGAKVNGKIAPLDTALKNGDVVEILTSKQSPGPSIDWLKIVKTASAKNKIRQFFKRERR
EENLARGKEILKGEVQKTGIEPHELMRDEWMAEVCRKVSVKDVDDLYVAIGIGSLNAASVVSRLREMYEKEKRAQEPAAP
VEIEKKDWSGYGKASNGIRVKGVSNLVVRLSRCCTPVPGDPIIGYVTRGRGVTVHRIDCPNMEDLAKDPDRLIEVAWEEN
YQTTAPVEVQVTALDRSGLLADVVSIIADARINMLSTSSRANKSKIATLDLVLEIRDAQQLQYVMNKIGKVRDVMHVERV
VRERRGKAARAKQA

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=714, Percent_Identity=42.156862745098, Blast_Score=575, Evalue=1e-165,
Organism=Escherichia coli, GI1789147, Length=688, Percent_Identity=40.406976744186, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI25143118, Length=133, Percent_Identity=36.0902255639098, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650996, Length=127, Percent_Identity=37.007874015748, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 83540; Mature: 83409

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVIDIQPLLDKVRSYNPTADVALIDNAFAFAKQAHEGQCRRSGEPYITHPIAVAEIVA
CCEEEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCCEECHHHHHHHHH
SLELDEESIAAALLHDVLEDCGVKYEELEERFGKEVATLVDGVSKLDRLQFTSRDEAQVE
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
NLRKMFLAMAKDLRVILIKLADRLHNMRTLKHQPSDAQVRIAQETMDIYAPLAHRLGLSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCHHH
IKWELEDLAFRILEPDRYQEMAYLVARKRQERMAITQDLMDQLREVLEKEGIQAEISGRP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
KHFYSIYKKMYRQGKDISQIYDLIAIRIIVEEVKDCYAVLGIIHSHWKPLPLRFKDYIAT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
PKPNMYQSLHTTVIGPHGEPFEIQIRTREMHRTAEFGVAAHWSYKEGKTDKEFDRKLQWL
CCCHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
RSLLEWHQEIRDAREFVESVKVDIFSDQVFVFSPKGHVFSLPAGGTPLDFAFAVHSDIGY
HHHHHHHHHHHHHHHHHHHHHHEEEECEEEEECCCCCEEECCCCCCCCHHHEEECCCCCC
RCVGAKVNGKIAPLDTALKNGDVVEILTSKQSPGPSIDWLKIVKTASAKNKIRQFFKRER
EEECCEECCEEECHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
REENLARGKEILKGEVQKTGIEPHELMRDEWMAEVCRKVSVKDVDDLYVAIGIGSLNAAS
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHH
VVSRLREMYEKEKRAQEPAAPVEIEKKDWSGYGKASNGIRVKGVSNLVVRLSRCCTPVPG
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCCC
DPIIGYVTRGRGVTVHRIDCPNMEDLAKDPDRLIEVAWEENYQTTAPVEVQVTALDRSGL
CCEEEEEECCCCEEEEEECCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCH
LADVVSIIADARINMLSTSSRANKSKIATLDLVLEIRDAQQLQYVMNKIGKVRDVMHVER
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRERRGKAARAKQA
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
TAVIDIQPLLDKVRSYNPTADVALIDNAFAFAKQAHEGQCRRSGEPYITHPIAVAEIVA
CEEEEHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCHHHCCCCCCEECHHHHHHHHH
SLELDEESIAAALLHDVLEDCGVKYEELEERFGKEVATLVDGVSKLDRLQFTSRDEAQVE
HHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
NLRKMFLAMAKDLRVILIKLADRLHNMRTLKHQPSDAQVRIAQETMDIYAPLAHRLGLSE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHCCHHH
IKWELEDLAFRILEPDRYQEMAYLVARKRQERMAITQDLMDQLREVLEKEGIQAEISGRP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
KHFYSIYKKMYRQGKDISQIYDLIAIRIIVEEVKDCYAVLGIIHSHWKPLPLRFKDYIAT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
PKPNMYQSLHTTVIGPHGEPFEIQIRTREMHRTAEFGVAAHWSYKEGKTDKEFDRKLQWL
CCCHHHHHHHHHEECCCCCCEEEEEEHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHH
RSLLEWHQEIRDAREFVESVKVDIFSDQVFVFSPKGHVFSLPAGGTPLDFAFAVHSDIGY
HHHHHHHHHHHHHHHHHHHHHHEEEECEEEEECCCCCEEECCCCCCCCHHHEEECCCCCC
RCVGAKVNGKIAPLDTALKNGDVVEILTSKQSPGPSIDWLKIVKTASAKNKIRQFFKRER
EEECCEECCEEECHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
REENLARGKEILKGEVQKTGIEPHELMRDEWMAEVCRKVSVKDVDDLYVAIGIGSLNAAS
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHH
VVSRLREMYEKEKRAQEPAAPVEIEKKDWSGYGKASNGIRVKGVSNLVVRLSRCCTPVPG
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHCCCCCC
DPIIGYVTRGRGVTVHRIDCPNMEDLAKDPDRLIEVAWEENYQTTAPVEVQVTALDRSGL
CCEEEEEECCCCEEEEEECCCCHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCH
LADVVSIIADARINMLSTSSRANKSKIATLDLVLEIRDAQQLQYVMNKIGKVRDVMHVER
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRERRGKAARAKQA
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]